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Kabiri, Mona, Bolourian, Haleh, Dehghan, Solmaz, Tafaghodi, Mohsen. (1399). The dry powder formulation of mixed cross-linked dextran microspheres and tetanus toxoid-loaded trimethyl chitosan nanospheres as a potent adjuvant for nasal delivery system. , 24(1), 116-122. doi: 10.22038/ijbms.2020.49486.11313
Mona Kabiri; Haleh Bolourian; Solmaz Dehghan; Mohsen Tafaghodi. "The dry powder formulation of mixed cross-linked dextran microspheres and tetanus toxoid-loaded trimethyl chitosan nanospheres as a potent adjuvant for nasal delivery system". , 24, 1, 1399, 116-122. doi: 10.22038/ijbms.2020.49486.11313
Kabiri, Mona, Bolourian, Haleh, Dehghan, Solmaz, Tafaghodi, Mohsen. (1399). 'The dry powder formulation of mixed cross-linked dextran microspheres and tetanus toxoid-loaded trimethyl chitosan nanospheres as a potent adjuvant for nasal delivery system', , 24(1), pp. 116-122. doi: 10.22038/ijbms.2020.49486.11313
Kabiri, Mona, Bolourian, Haleh, Dehghan, Solmaz, Tafaghodi, Mohsen. The dry powder formulation of mixed cross-linked dextran microspheres and tetanus toxoid-loaded trimethyl chitosan nanospheres as a potent adjuvant for nasal delivery system. , 1399; 24(1): 116-122. doi: 10.22038/ijbms.2020.49486.11313

The dry powder formulation of mixed cross-linked dextran microspheres and tetanus toxoid-loaded trimethyl chitosan nanospheres as a potent adjuvant for nasal delivery system

Iranian Journal of Basic Medical Sciences
مقاله 17، دوره 24، شماره 1، فروردین 2021، صفحه 116-122    اصل مقاله (757.49 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.49486.11313
نویسندگان
Mona Kabiri1، 2، 3؛ Haleh Bolourian2؛ Solmaz Dehghan1، 4؛ Mohsen Tafaghodi* 1، 2
1Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4Biotechnology Center, Gilead Sciences, Foster City, USA
چکیده
Objective(s): The present study aimed to determine the immunoadjuvant efficacy of mixed cross-linked dextran microspheres (CDM) and tetanus toxoid (TT)-loaded trimethyl chitosan (TMC) nanospheres in dry powder form.
Materials and Methods: The TMC nanoparticles (NPs) containing TT were produced using the ionic gelation method. Co-administration of TT-loaded TMC NPs and CDM as an absorption enhancer was performed to improve immunity against the antigen. Dry powder formulations were delivered via the nasal route in a rabbit model.
Results: Among immunization groups, mixing of CDM with TT encapsulated in TMC NPs could elicit the highest titer of systemic IgG antibody. Furthermore, the addition of CDM to TT-loaded TMC enhanced the sIgA response relative to the TT solution.
Conclusion: The TMC NPs had a considerable effect on mucosal and systemic immunity against the TT antigen. Therefore, the CDM excipient can be utilized for nasal immunization to elevate systemic and mucosal responses.
کلیدواژه‌ها
Cross؛ linked dextran microspheres Mucosal immunity Nasal immunization Systemic responses Tetanus toxoid Trimethyl chitosan nanoparticles
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