The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 12، دوره 16، شماره 9، آذر 2013، صفحه 1022-1026 اصل مقاله (404.07 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.1685 | ||
| نویسندگان | ||
| Zahra Gholamnezhad؛ Hamed Koushyar؛ Goltaj Byrami؛ Mohammad Hossein Boskabady* | ||
| Applied Physiology Research Centre, and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. Materials and Methods: Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n=6, for all groups) and serum levels of endotheline-1 (ET-1) and total protein (TP) were assessed. Results: Serum levels of ET-1 and TP in group S were significantly higher than control group (P Conclusion: A preventive effect of the extract of C. sativus and its constituent safranal on serum inflammatory markers in sensitized guinea pigs was shown. | ||
| کلیدواژهها | ||
| Asthma Crocus sativus Endotheline Inflammation Safranal Sensitization | ||
| مراجع | ||
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