Toktay, Erdem, Selli, Jale, Gurbuz, Muhammed, Tastan, Tugba, Ugan, Rustem Anil, Un, Harun, Halici, Zekai. (1399). Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity. , 23(12), 1603-1609. doi: 10.22038/ijbms.2020.48294.11089
Erdem Toktay; Jale Selli; Muhammed Ali Gurbuz; Tugba Bal Tastan; Rustem Anil Ugan; Harun Un; Zekai Halici. "Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity". , 23, 12, 1399, 1603-1609. doi: 10.22038/ijbms.2020.48294.11089
Toktay, Erdem, Selli, Jale, Gurbuz, Muhammed, Tastan, Tugba, Ugan, Rustem Anil, Un, Harun, Halici, Zekai. (1399). 'Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity', , 23(12), pp. 1603-1609. doi: 10.22038/ijbms.2020.48294.11089
Toktay, Erdem, Selli, Jale, Gurbuz, Muhammed, Tastan, Tugba, Ugan, Rustem Anil, Un, Harun, Halici, Zekai. Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity. , 1399; 23(12): 1603-1609. doi: 10.22038/ijbms.2020.48294.11089

Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 23، شماره 12، اسفند 2020، صفحه 1603-1609    اصل مقاله (1.29 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.48294.11089
نویسندگان
Erdem Toktay* 1؛ Jale Selli2؛ Muhammed Ali Gurbuz3؛ Tugba Bal Tastan3؛ Rustem Anil Ugan4؛ Harun Un5؛ Zekai Halici6
1Kafkas University, Faculty of Medicine, Department of Histology and Embryology, Kars
2Alanya Alaaddin Keykubat University, Faculty of Medicine, Department of Histology and Embryology, Antalya
3Ataturk University, Faculty of Medicine, Department of Histology and Embryology, Erzurum
4Ataturk University, Faculty of Pharmacy, Department of Pharmacology, Erzurum
5Agrı Ibrahim Cecen University, Faculty of Pharmacy, Department of biochemistry, Ağrı
6Ataturk University, Faculty of Medicine, Department of Pharmacology, Erzurum
چکیده
Objective(s): This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.
Materials and Methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of genistein and daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically.
Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose genistein and daidzein groups. When compared with the endometrial receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin β3, integrin αvβ3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of genistein and daidzein groups.  In biochemical evaluations, it was determined that genistein and daidzein increased estrogen levels and decreased progesterone levels in a dose-dependent manner.  
Conclusion: Genistein and daidzein have a negative effect on endometrial receptivity.  Therefore, individuals with a risk of infertility should pay attention to the consumption of genistein and daidzein.
کلیدواژه‌ها
Daidzein؛ Endometrial Receptivity؛ Genistein؛ Rat؛ Soy Isoflavonoids
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