Docking Studies of Phthalimide Pharmacophore as a Sodium Channel Blocker | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 11، دوره 16، شماره 9، آذر 2013، صفحه 1016-1021 اصل مقاله (796.92 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.1684 | ||
| نویسندگان | ||
| Maryam Iman1؛ Atefeh Saadabadi2؛ Asghar Davood* 2 | ||
| 1Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 2Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Objective(s): Recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. The ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. Therefore, in the present study, a series of 19 compounds of phthalimide pharmacophore possessing a variety of substituents (NO2, NH2 , Me, Cl, COOH, MeO) at 2-, 3-, and 4- position of the N-phenyl ring and N-(3-amino-2-methylphenyl) succinimide, were subjected to docking studies in order to inhibit voltage-gated sodium channels. Materials and Methods : Chemical structures of all compounds were designed using HYPERCHEM program and Conformational studies were performed through semi-empirical molecular orbital calculations method followed by PM3 force field. Total energy gradient calculated as a root mean square (RMS) value, until the RMS gradient was 0.01 kcal mol-1. Among all energy minima conformers, the global minimum of compounds was used in docking calculations. Using a model of the open pore of Na channels, docking study was performed by AUTODOCK4.2 program. Results : Docking studies have revealed that these types of ligands interacted mainly with II-S6 residues of NaV1.2 through making hydrogen bonds and have additional hydrophobic interactions with domain I, II, III and IV in the channel's inner pore. Conclusion : These computational studies have displayed that these compounds are capable of inhibiting Na channel, efficiently. | ||
| کلیدواژهها | ||
| Anticonvulsant Docking Molecular modeling Na channel Phthalimide | ||
| مراجع | ||
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