Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 9، دوره 16، شماره 9، آذر 2013، صفحه 1004-1010 اصل مقاله (570.25 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.1682 | ||
| نویسندگان | ||
| Alireza Sarkaki1؛ Maryam Rafieirad2؛ Seyed Ebrahim Hossini3؛ Yaghoub Farbood* 4؛ Fereshteh Motamedi5؛ Seyed Mohammad Taghi Mansouri6؛ Bahareh Naghizadeh6 | ||
| 1Physiology Research Center and Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 2Department of Biology, Sciences Faculty, Islamic Azad University, Izeh Branch, Izeh, Iran | ||
| 3Department of Biology, Sciences & Researches Branch, Islamic Azad University, Fars, Iran | ||
| 4Department of Physiology and Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 5Iranian Neurosciences Research Network and Neurosciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| 6Department of Pharmacology and Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| چکیده | ||
| Objective(s): Cerebral hypoperfusion/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of grape seed extract (GSE) on passive avoidance memory and long-term potentiation (LTP) after permanent bilateral common carotid arteries occlusion (2CCAO) in male adult rats. Materials and Methods: Thirty-two adult male Wistar rats were randomly divided into: 1) Sham+Veh, 2) Isch+Veh, 3) Sham+GSE, 4) Isch+GSE. In order to make 2CCAO as an animal model of CHI, carotid arteries were ligatured and then cut bilaterally. To evaluation of passive avoidance memory, step-down latency (STL) was measured and LTP was recorded from hippocampal dentate gyrus (DG) after high frequency stimulation (HFS) in all rats. Results: We found that memory was significantly impaired in rats after CHI (P<0.001) concomitant with hippocampal LTP inhibition (P<0.05, P1 and LTP48 respectively). GSE treatment significantly improved memory impairment and increased hippocampal LTP in rats with 2CCAO. Conclusion: Our results in present study suggest that GSE exhibits therapeutic potential for short-and long-term memories as well as LTP in DG, which is most likely related at least in part to its antioxidative and free radical scavenging actions. | ||
| کلیدواژهها | ||
| grape seed extract؛ Hypoperfusion-Ischemia LTP Memory Rat | ||
| مراجع | ||
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