Genetic Variations of Tumor Necrosis Factor –α-308 and Lymphtoxin-α+252 in Non-Hodgkin Lymphoma and Acute Lymphoblastic Leukemia Patients | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 7، دوره 16، شماره 9، آذر 2013، صفحه 990-995 اصل مقاله (431.81 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.1680 | ||
| نویسندگان | ||
| Hajar Nasiri1؛ Safar Farajnia2؛ Azim Rezamand3؛ Ali Akbar MovassaghPour1؛ Heydar Ali Esmaeili1؛ Amir Monfaredan4؛ Naser Mobarra5؛ Nasser Rahimifar1؛ Leyla Sahebi6؛ Majid Farshdousti Hagh* 7 | ||
| 1School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 3Childeren Hospital, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 4Tabriz branch, Islamic Azad University of Medical Science, Tabriz, Iran | ||
| 5Clinical Biochemistry Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 6Tuberclosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 7Hematology & Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| چکیده | ||
| Objective(s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-α (TNF-α) -308 and lymphotoxin-α (LT-α) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-α (-308) and LT-α (+ 252) polymorphisms are different for NHL and ALL cases in various populations with different ethnicity. This research is designed to investigate the prevalence and association of TNF-α (-308) and LT-α (+ 252) polymorphisms from NHL and ALL in Azarian patients and healthy individuals from Northwestern part of Iran. Materials and Methods: Seventy subjects with ALL and 68 NHL, along with another 130 healthy subjects as control group took part in this study. Genomic DNA was extracted, then genetic polymorphisms in TNF-α and LT-α genes were analyzed with the PCR-RFLP and NCOI as restriction enzyme. A statistical analysis was performed by chi-square test using SPSS software. A P-value of <0.05 was considered statistically significant. Results: A statistically significant difference of LT-α polymorphism was in NHL patients and control (P-value= 0.008) but there was not any association of TNF-α polymorphism between NHL patients and control group. A significant association for TNF-a variant was in ALL and control (P-value =0.005), however, there was no relationship about LT variant between ALL and control. Conclusion: The results show that there are significant differences between TNF-α (-308) and LT-α (+252) genetic polymorphisms respectively in ALL and NHL patients with control group from Northwestern part of Iran. | ||
| کلیدواژهها | ||
| Acute lymphocytic leuke- mia LT-α Non-Hodgkin lymphoma Polymorphism TNF-α | ||
| مراجع | ||
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