Abscisic acid interplays with PPARγ receptors and ameliorates diabetes-induced cognitive deficits in rats | ||
Avicenna Journal of Phytomedicine | ||
مقاله 5، دوره 11، شماره 3، مرداد و شهریور 2021، صفحه 247-257 اصل مقاله (916.15 K) | ||
نوع مقاله: Original Research Article | ||
شناسه دیجیتال (DOI): 10.22038/ajp.2020.16777 | ||
نویسندگان | ||
Razieh Kooshki1؛ Akbar Anaeigoudari* 2؛ Mehdi Abbasnejad3؛ Khadijeh Askari-Zahabi3؛ Saeed Esmaeili-Mahani3 | ||
1Department of Biology, Faculty of Sciences, Lorestan University, Khorramabad, Iran | ||
2Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran | ||
3Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran | ||
چکیده | ||
Objective: This study intended to evaluate if central administration of abscisic acid (ABA) alone or in combination with GW9662, a peroxisome proliferator–activated receptor γ (PPAR-γ) antagonist, could modulate learning and memory as well as hippocampal synaptic plasticity in a rat model of streptozotocin (STZ)–induced diabetes. Materials and Methods: Intraperitoneal injection of STZ (65 mg/kg) was used to induce diabetes. Diabetic rats were than treated with intracerebroventricular (i.c.v.) administration of ABA (10, 15 and 20 µg/rat), GW9662 (3 µg/rat) or GW9662 (3 µg/rat) plus ABA (20 µg/rat).Animals’ spatial and passive avoidance learning and memory performances were assessed by Morris water maze (MWM) and shuttle box tasks, respectively. Further, in vivo electrophysiological field recordings were assessed in the CA1 region. Results: STZ diabetic rats showed diminished learning and memory in both MWM and shuttle box tasks. The STZ-induced memory deficits were attenuated by central infusion of ABA (10 and 20 µg/rat). Besides, STZ injection impaired long-term potentiation induction in CA1 neurons that was attenuated by ABA at 20 μg/rat. Central administration of GW9662 (3 µg/rat) alone did not modify STZ-induced spatial and passive avoidance learning and memory performances of rats. Further, GW9662 prevented ABA capacity to restore learning and memory in behavioral and electrophysiology trials. Conclusion: Altogether, ABA ameliorates cognitive deficits in rats via activation of PPAR-γ receptor in diabetic rats. | ||
کلیدواژهها | ||
Diabetes mellitus؛ Streptozotocin؛ Abscisic acid؛ Long term potentiation؛ Learning and memory؛ Rats | ||
مراجع | ||
Ahmed A, Zeng G, Jiang D, Lin H, Azhar M, Farooq AD, Choudhary MI, Liu X, Wang Q. 2019. Time-dependent impairments in learning and memory in Streptozotocininduced hyperglycemic rats. Met Brain Dis, 1-16. Arora S, Ojha SK, Vohora D. 2009. Characterisation of streptozotocin induced diabetes mellitus in swiss albino mice. Global J Pharmacol, 3: 81-84. Bahrami F, Asgari A, Hosseinmardi N, Janahmadi M. 2019. Peroxisome Proliferator-activated Receptor (PPAR)-γ Modifies Aβ Neurotoxin-induced Electrophysiological Alterations in Rat Primary Cultured Hippocampal Neurons. Ira J Pharm Res, 18: 1403-1418. Bassaganya-Riera J, Guri AJ, Lu P, Climent M, Carbo A, Sobral BW, Horne WT, Lewis SN, Bevan DR, Hontecillas R. 2011. Abscisic acid regulates inflammation via ligandbinding domain-independent activation of peroxisome proliferator-activated receptor γ. J Biol Chem, 286: 2504-2516. Bassani TB, Bonato JM, Machado MM, Cóppola-Segovia V, Moura EL, Zanata SM, Oliveira RM, Vital MA. 2018. Decrease in adult neurogenesis and neuroinflammation are involved in spatial memory impairment in the streptozotocin-induced model of sporadic Alzheimer’s disease in rats. Mol Neurobiol, 55: 4280-4296. Bruzzone S, Bodrato N, Usai C, Guida L, Moreschi I, Nano R, Antonioli B, Fruscione F, Magnone M, Scarfì, S. 2008. Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger. J Biol Chem, 283: 32188-32197. Chen H, Liu Q, Salter AM, Lomax MA. 2013. Synergism between cAMP and PPAR Signalling in the Initiation of UCP1 Gene Expression in HIB1B Brown Adipocytes. PPAR Res, 2013. Cheng H, Shang Y, Jiang L, Shi Tl, Wang L. 2016. The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis. Int J Neurosci, 126: 299-307. Costello D A, O'Leary DM, Herron CE. 2005. Agonists of peroxisome proliferatoractivated receptor-γ attenuate the Aβmediated impairment of LTP in the hippocampus in vitro. Neuropharmacol, 49: 359-366. Furman B L. 2015. Streptozotocin‐induced diabetic models in mice and rats. Curr Protoc Pharmacol, 70: 5.47. 41-45.47. 20. Gerozissis K. 2008. Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies. Eur J Pharmacol, 585: 38-49. Guri AJ, Evans NP, Hontecillas R, BassaganyaRiera J. 2011. T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD. J Nutr Biochem, 22: 812-819. Guri AJ, Hontecillas R, Bassaganya-Riera J. 2010. Abscisic acid synergizes with rosiglitazone to improve glucose tolerance Kooshki et al. AJP, Vol. 11, No. 3, May-Jun 2021 256 and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR γ axis. Clin Nutr, 29: 646-653. Han H, Wu Lm, Han MX, Yang WX, Wang YX, Fang ZH. 2016. Diabetes impairs spatial learning and memory and hippocampal neurogenesis via BDNF in rats with transient global ischemia. Brain Res Bull, 124: 269-277. Hauser F, Li Z, Waadt R, Schroeder JI .2017. SnapShot: abscisic acid signaling. Cell, 171: 1708-1708. e1700. Jiang L Y, Tang SS, Wang XY, Liu LP, Long Y, Hu M, Liao MX, Ding QL, Hu W, Li JC. 2012. PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus. CNS neuroscience & therapeutics, 18: 659-666. Khorasani A, Abbasnejad M, Esmaeili-Mahani S. 2019.Phytohormone abscisic acid ameliorates cognitive impairments in streptozotocin-induced rat model of Alzheimer's disease through PPARβ/δ and PKA signaling. Int J Neurosci, 1-17. Kline K G, Sussman MR, Jones AM. 2010. Abscisic acid receptors. Plant Phys, 154: 479-482. Kota B P, Huang TH-W, Roufogalis BD. 2005. An overview on biological mechanisms of PPARs. Pharmacol Res, 51: 85-94. Landreth G, Jiang Q, Mandrekar S, Heneka M. 2008. PPARγ agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics, 5: 481-489. Lievens L, Pollier J, Goossens A, Beyaert R, Staal J. 2017. Abscisic acid as pathogen effector and immune regulator. Front Plant Sci, 8: 587. Lin CH, Nicol CJ, Cheng YC, Chen SJ, Yen CH, Huang RN, Chiang MC. 2018.Rosiglitazone rescues human neural stem cells from amyloid-beta induced ER stress via PPARγ dependent signaling. Exp Cell Res, 370: 312-321. Liu Lp, Yan TH, Jiang LY, Hu W, Hu M, Wang C, Zhang Q, Long Y, Wang JQ, Li YQ. 2013. Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation. Acta Pharmacologica Sinica, 34: 455. Lotfy M, AdeghateJ, Kalasz H, Singh J, AdeghateE. 2017. Chronic complications of diabetes mellitus: a mini review. Curr Diabetes Rev, 13: 3-10. Masciopinto F, Di Pietro N, Corona C, Bomba M, Pipino C, Curcio M, Di Castelnuovo A, Ciavardelli D, Silvestri E, Canzoniero LM. 2012. Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wildtype mice. Cell death Dis, 3: e448. Mollashahi M, Abbasnejad M, EsmaeiliMahani S. 2018. Phytohormone abscisic acid elicits antinociceptive effects in rats through the activation of opioid and peroxisome proliferator-activated receptors β/δ. Eur J Pharmacol, 832: 75-80. Naderi R, Esmaeili-Mahani S, Abbasnejad M. 2017. Phosphatidylinositol-3-kinase and protein kinase C are involved in the procognitive and anti-anxiety effects of phytohormone abscisic acid in rats. Biomed Pharmacother, 96: 112-119. Naderi R, Esmaeili-Mahani S, Abbasnejad M. 2019. Extracellular calcium influx through L-type calcium channels, intracellular calcium currents and extracellular signalregulated kinase signaling are involved in the abscisic acid-induced precognitive and anti-anxiety effects. Biomed Pharmacother, 109: 582-588. Owen SC, Doak AK, Ganesh AN, Nedyalkova L, McLaughlin CK, Shoichet BK, Shoichet MS. 2014. Colloidal drug formulations can explain “bell-shaped” concentration– response curves. ACS Chem Biol, 9: 777- 784. Paxinos G, Watson C. 1998. The rat brain in stereotaxic CO—ordinatesEM-1. The 2nd Edition. USA San Diego, Ac—ademic Pres, 36-34O. Popoviç M, Biessels G-J, Isaacson RL, Gispen WH. 2001. Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task. Behav Brain Res, 122: 201-207. Qi CC, Ge JF, Zhou JN. 2015. Preliminary evidence that abscisic acid improves spatial memory in rats. Phys Behav 139: 231-239. Raghavendra AS, Gonugunta VK, Christmann A, Grill E. 2010. ABA perception and signalling. Trends Plant Sci, 15: 395-401 Shonesy B C, Thiruchelvam K, Parameshwaran K, Rahman EA, Karuppagounder SS, Huggins KW, Pinkert CA, Amin R, Dhanasekaran M, Suppiramaniam V. 2012. Central insulin resistance and synaptic ABA effects on diabetes-induced memory deficiency AJP, Vol. 11, No. 3, May-Jun 2021 257 dysfunction in intracerebroventricularstreptozotocin injected rodents. Neurobiol Aging, 33: 430. e435-430. e418. Singh S, Simpson RL, Bennett RG. 2015. Relaxin activates peroxisome proliferatoractivated receptor γ (PPARγ) through a pathway involving PPARγ coactivator 1α (PGC1α). J Biol Chem, 290: 950-959. Sripetchwandee J, Pipatpiboon N, Pratchayasakul W, Chattipakorn N, Chattipakorn SC .2014. DPP-4 inhibitor and PPARγ agonist restore the loss of CA1 dendritic spines in obese insulin-resistant rats. Arch Med Res, 45: 547-552. Struck MB, Andrutis K A, Ramirez H E, Battles A H. 2011. Effect of a short-term fast on ketamine–xylazine anesthesia in rats. J Am Assoc Lab Anim Sci, 50: 344-348. Sturla L, Mannino E, Scarfì S, Bruzzone S, Magnone M, Sociali G, Booz V, Guida L, Vigliarolo T, Fresia C. 2017. Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1862: 131-144. Xu ZP, Li L, Bao J, Wang ZH, Zeng J, Liu EJ, Li XG, Huang RX, Gao D, Li MZ. 2014. Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer’s model. PloS one, 9(9), e108645. Yang H, Fan S, Song D, Wang Z, Ma S, Li S, Li X, Xu M, Xu M, Wang X. 2013. Longterm streptozotocin-induced diabetes in rats leads to severe damage of brain blood vessels and neurons via enhanced oxidative stress. Mol Med Rep, 7: 431-440. Yasmin S, Jayaprakash V. 2017. Thiazolidinediones and PPAR orchestra as antidiabetic agents: From past to present. Eur J Med Chem, 126: 879-893. Yau SY, Lee TH Y, Li A, Xu A, So KF. 2018. Adiponectin mediates running-restored hippocampal neurogenesis in streptozotocin-induced type 1 diabetes in mice. Front Neurosci, 12. Yazir Y, Polat S, Utkan T, Aricioglu F. 2019.Role of the nitric oxide-soluble guanylyl cyclase pathway in cognitive deficits in streptozotocin-induced diabetic rats. Psych Clin Psychopharmacol, 29: 34- 44. Zocchi E, Hontecillas R, Leber A, Einerhand A, Carbo A, Bruzzone S, Tubau-Juni N, Philipson N, Zoccoli-Rodriguez V, Sturla L. 2017. Abscisic acid: a novel nutraceutical for glycemic control. Front Nutr, 4: 24. | ||
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