Emadi, Elnaz, Pouramir, Mahdi, Ghasemi-Kasman, Maryam, Feizi, Farideh, Halalkhor, Sohrab, Moghadamnia, Ali Akbar. (1400). Arbutin attenuates nephrotoxicity induced by gentamicin. , 11(3), 210-217. doi: 10.22038/ajp.2020.16776
Elnaz Emadi; Mahdi Pouramir; Maryam Ghasemi-Kasman; Farideh Feizi; Sohrab Halalkhor; Ali Akbar Moghadamnia. "Arbutin attenuates nephrotoxicity induced by gentamicin". , 11, 3, 1400, 210-217. doi: 10.22038/ajp.2020.16776
Emadi, Elnaz, Pouramir, Mahdi, Ghasemi-Kasman, Maryam, Feizi, Farideh, Halalkhor, Sohrab, Moghadamnia, Ali Akbar. (1400). 'Arbutin attenuates nephrotoxicity induced by gentamicin', , 11(3), pp. 210-217. doi: 10.22038/ajp.2020.16776
Emadi, Elnaz, Pouramir, Mahdi, Ghasemi-Kasman, Maryam, Feizi, Farideh, Halalkhor, Sohrab, Moghadamnia, Ali Akbar. Arbutin attenuates nephrotoxicity induced by gentamicin. , 1400; 11(3): 210-217. doi: 10.22038/ajp.2020.16776

Arbutin attenuates nephrotoxicity induced by gentamicin

Avicenna Journal of Phytomedicine
مقاله 1، دوره 11، شماره 3، مرداد و شهریور 2021، صفحه 210-217    اصل مقاله (558.13 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.22038/ajp.2020.16776
نویسندگان
Elnaz Emadi1؛ Mahdi Pouramir* 1؛ Maryam Ghasemi-Kasman2؛ Farideh Feizi3؛ Sohrab Halalkhor1؛ Ali Akbar Moghadamnia4
1Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
2Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3Department of Anatomy, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
4Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
چکیده
Objective: In this study, the impact of arbutin was examined in a gentamicin (GM)-induced nephrotoxicity model.
Materials and Methods: Forty adult male Wistar rats were randomly assigned to five groups including control group; GM group, and three groups of GM+arbutin (25, 50 and 75 mg/kg). One day after the last injection of GM, creatinine, urea, carbonyl, thiobarbituric acid-reacting substance (TBARs), ferric reducing antioxidant power (FRAP) and 8-hydroxyguanosine levels were assessed in serum samples. Left and right kidneys were used for biochemical assays and histological evaluation, respectively.
Results: Our data showed that the FRAP level (p<0.05), urea (p<0.001), creatinine (p<0.001), and 8-hydroxyguanosine (p<0.001) levels of serum samples, were increased in GM-treated rats compared to the controls. The serum levels of TBARS (p<0.001) and carbonyl increased in serum and renal tissue (p<0.001) of GM-treated animals. Conversely, arbutin attenuated serum creatinine, urea and 8-hydroxyguanosine, and TBARS (p<0.001). Administration of arbutin significantly decreased carbonyl levels in serum and renal tissue samples (p<0.001). Furthermore, the levels of FRAP increased in the serum (p<0.01) and renal tissue samples (p<0.001) of arbutin-treated animals. Histological staining showed that arbutin significantly inhibits kidney damages.
Conclusion: Our data suggest that arbutin attenuates GM-induced nephrotoxicity through its free radicals-scavenging activity.
کلیدواژه‌ها
Gentamicin؛ Nephrotoxicity؛ Arbutin؛ Antioxidant؛ Histopathology
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