Arbutin attenuates nephrotoxicity induced by gentamicin | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 1، دوره 11، شماره 3، مرداد و شهریور 2021، صفحه 210-217 اصل مقاله (558.13 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2020.16776 | ||
| نویسندگان | ||
| Elnaz Emadi1؛ Mahdi Pouramir* 1؛ Maryam Ghasemi-Kasman2؛ Farideh Feizi3؛ Sohrab Halalkhor1؛ Ali Akbar Moghadamnia4 | ||
| 1Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran | ||
| 2Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran | ||
| 3Department of Anatomy, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran | ||
| 4Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran | ||
| چکیده | ||
| Objective: In this study, the impact of arbutin was examined in a gentamicin (GM)-induced nephrotoxicity model. Materials and Methods: Forty adult male Wistar rats were randomly assigned to five groups including control group; GM group, and three groups of GM+arbutin (25, 50 and 75 mg/kg). One day after the last injection of GM, creatinine, urea, carbonyl, thiobarbituric acid-reacting substance (TBARs), ferric reducing antioxidant power (FRAP) and 8-hydroxyguanosine levels were assessed in serum samples. Left and right kidneys were used for biochemical assays and histological evaluation, respectively. Results: Our data showed that the FRAP level (p<0.05), urea (p<0.001), creatinine (p<0.001), and 8-hydroxyguanosine (p<0.001) levels of serum samples, were increased in GM-treated rats compared to the controls. The serum levels of TBARS (p<0.001) and carbonyl increased in serum and renal tissue (p<0.001) of GM-treated animals. Conversely, arbutin attenuated serum creatinine, urea and 8-hydroxyguanosine, and TBARS (p<0.001). Administration of arbutin significantly decreased carbonyl levels in serum and renal tissue samples (p<0.001). Furthermore, the levels of FRAP increased in the serum (p<0.01) and renal tissue samples (p<0.001) of arbutin-treated animals. Histological staining showed that arbutin significantly inhibits kidney damages. Conclusion: Our data suggest that arbutin attenuates GM-induced nephrotoxicity through its free radicals-scavenging activity. | ||
| کلیدواژهها | ||
| Gentamicin؛ Nephrotoxicity؛ Arbutin؛ Antioxidant؛ Histopathology | ||
| مراجع | ||
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