Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression | ||
| Asia Oceania Journal of Nuclear Medicine and Biology | ||
| مقاله 7، دوره 9، شماره 1، فروردین 2021، صفحه 45-50 اصل مقاله (1.29 M) | ||
| نوع مقاله: Case report | ||
| شناسه دیجیتال (DOI): 10.22038/aojnmb.2020.48887.1332 | ||
| نویسندگان | ||
| NIKITA SAMPATHIRAO* 1؛ Indirani M Muthukrishnan1؛ Ann Kurian2؛ Jaykanth Amalchandran1؛ Asra Patel1؛ shema mathew1؛ Shelley Simon1 | ||
| 1Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India | ||
| 2Department of Pathology, Apollo Hospitals, Chennai, India | ||
| چکیده | ||
| High-grade B-cell lymphoma, an aggressive form of Non-Hodgkin’s Lymphoma, is known as a double or triple hit lymphoma based on the presence of MYC and BCL2 without or with BCL6 genetic rearrangements, respectively. It carries a poorer prognosis, compared to other variants of B-cell lymphoma, and its management also differs which requires more intensive chemotherapy in contrast to the routine regimen. Terminal deoxynucleotidyl transferase (TdT), a marker of immaturity is commonly expressed in B-cell lymphoblastic leukemia or lymphoma (B cell ALL) which is absent in mature forms of B-cell lymphoma. The TdT is expressed in high-grade B-cell lymphoma; therefore, it poses a classification and management dilemma, which should be accurately differentiated from B-cell ALL and mandates molecular analysis. Herein, we report a case of a 52-year-old female with biopsy reported as high-grade B-cell lymphoma with TdT expression. She was referred for Fluor-deoxyglucose (FDG) Positron Emission Tomography-Computed Tomography (PET/CT) scan for staging in the absence of molecular analysis for B-cell ALL. It was diagnosed as lymphoma on FDG PET/CT based on its characteristic findings of extensive extranodal involvement of multiple organs with no significant lymphadenopathy establishing the incremental value of FDG PET/CT scan, which helped the clinician to arrive at a conclusion. | ||
| کلیدواژهها | ||
| TdT expression؛ Extranodal B cell lymphoma؛ FDG PET/CT | ||
| مراجع | ||
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