SAMPATHIRAO, NIKITA, Muthukrishnan, Indirani, Kurian, Ann, Amalchandran, Jaykanth, Patel, Asra, mathew, shema, Simon, Shelley. (1399). Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression. , 9(1), 45-50. doi: 10.22038/aojnmb.2020.48887.1332
NIKITA SAMPATHIRAO; Indirani M Muthukrishnan; Ann Kurian; Jaykanth Amalchandran; Asra Patel; shema mathew; Shelley Simon. "Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression". , 9, 1, 1399, 45-50. doi: 10.22038/aojnmb.2020.48887.1332
SAMPATHIRAO, NIKITA, Muthukrishnan, Indirani, Kurian, Ann, Amalchandran, Jaykanth, Patel, Asra, mathew, shema, Simon, Shelley. (1399). 'Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression', , 9(1), pp. 45-50. doi: 10.22038/aojnmb.2020.48887.1332
SAMPATHIRAO, NIKITA, Muthukrishnan, Indirani, Kurian, Ann, Amalchandran, Jaykanth, Patel, Asra, mathew, shema, Simon, Shelley. Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression. , 1399; 9(1): 45-50. doi: 10.22038/aojnmb.2020.48887.1332

Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 7، دوره 9، شماره 1، فروردین 2021، صفحه 45-50    اصل مقاله (1.29 M)
نوع مقاله: Case report
شناسه دیجیتال (DOI): 10.22038/aojnmb.2020.48887.1332
نویسندگان
NIKITA SAMPATHIRAO* 1؛ Indirani M Muthukrishnan1؛ Ann Kurian2؛ Jaykanth Amalchandran1؛ Asra Patel1؛ shema mathew1؛ Shelley Simon1
1Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India
2Department of Pathology, Apollo Hospitals, Chennai, India
چکیده
High-grade B-cell lymphoma, an aggressive form of Non-Hodgkin’s Lymphoma, is known as a double or triple hit lymphoma based on the presence of MYC and BCL2 without or with BCL6 genetic rearrangements, respectively. It carries a poorer prognosis, compared to other variants of B-cell lymphoma, and its management also differs which requires more intensive chemotherapy in contrast to the routine regimen. Terminal deoxynucleotidyl transferase (TdT), a marker of immaturity is commonly expressed in B-cell lymphoblastic leukemia or lymphoma (B cell ALL) which is absent in mature forms of B-cell lymphoma. The TdT is expressed in high-grade B-cell lymphoma; therefore, it poses a classification and management dilemma, which should be accurately differentiated from B-cell ALL and mandates molecular analysis. Herein, we report a case of a 52-year-old female with biopsy reported as high-grade B-cell lymphoma with TdT expression. She was referred for Fluor-deoxyglucose (FDG) Positron Emission Tomography-Computed Tomography (PET/CT) scan for staging in the absence of molecular analysis for B-cell ALL. It was diagnosed as lymphoma on FDG PET/CT based on its characteristic findings of extensive extranodal involvement of multiple organs with no significant lymphadenopathy establishing the incremental value of FDG PET/CT scan, which helped the clinician to arrive at a conclusion.
کلیدواژه‌ها
TdT expression؛ Extranodal B cell lymphoma؛ FDG PET/CT
مراجع
آمار
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