Panda, Ananya, McCarthy, Michael, Murray, Joseph, Sharain, Rosalind, Shi, Min, Kendi, Ayse. (1399). Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic. , 9(1), 51-55. doi: 10.22038/aojnmb.2020.49000.1333
Ananya Panda; Michael R. McCarthy; Joseph A Murray; Rosalind F. Sharain; Min Shi; Ayse Kendi. "Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic". , 9, 1, 1399, 51-55. doi: 10.22038/aojnmb.2020.49000.1333
Panda, Ananya, McCarthy, Michael, Murray, Joseph, Sharain, Rosalind, Shi, Min, Kendi, Ayse. (1399). 'Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic', , 9(1), pp. 51-55. doi: 10.22038/aojnmb.2020.49000.1333
Panda, Ananya, McCarthy, Michael, Murray, Joseph, Sharain, Rosalind, Shi, Min, Kendi, Ayse. Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic. , 1399; 9(1): 51-55. doi: 10.22038/aojnmb.2020.49000.1333

Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 8، دوره 9، شماره 1، فروردین 2021، صفحه 51-55    اصل مقاله (879.73 K)
نوع مقاله: Case report
شناسه دیجیتال (DOI): 10.22038/aojnmb.2020.49000.1333
نویسندگان
Ananya Panda1؛ Michael R. McCarthy2؛ Joseph A Murray3؛ Rosalind F. Sharain2؛ Min Shi2؛ Ayse Kendi* 1
1Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
2Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA
3Departments of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
چکیده
Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or extra-intestinal manifestations. Typical 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) gastrointestinal manifestations of celiac disease include increased multifocal or diffuse jejunal and ileal uptake; focal duodenal uptake is less common. Splenomegaly with increased splenic FDG uptake is also uncommon in celiac disease in the absence of portal hypertension; small-sized spleen and functional hyposplenism are more typical. We report a case of celiac disease diagnosed after PET/CT showed FDG uptake in the duodenum and enlarged spleen. Follow-up after gluten-free diet showed complete metabolic resolution and regression of splenomegaly. The combination of focal bowel and splenic uptake is unusual in celiac disease and may be mistaken for a lymphoproliferative disorder. Awareness of this entity may avoid misdiagnosis and guide appropriate management.
کلیدواژه‌ها
Celiac disease؛ Splenomegaly؛ 18F-FDG PET/CT؛ Incidental bowel uptake؛ Lymphoma
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