Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic | ||
| Asia Oceania Journal of Nuclear Medicine and Biology | ||
| مقاله 8، دوره 9، شماره 1، فروردین 2021، صفحه 51-55 اصل مقاله (879.73 K) | ||
| نوع مقاله: Case report | ||
| شناسه دیجیتال (DOI): 10.22038/aojnmb.2020.49000.1333 | ||
| نویسندگان | ||
| Ananya Panda1؛ Michael R. McCarthy2؛ Joseph A Murray3؛ Rosalind F. Sharain2؛ Min Shi2؛ Ayse Kendi* 1 | ||
| 1Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA | ||
| 2Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA | ||
| 3Departments of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA | ||
| چکیده | ||
| Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or extra-intestinal manifestations. Typical 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) gastrointestinal manifestations of celiac disease include increased multifocal or diffuse jejunal and ileal uptake; focal duodenal uptake is less common. Splenomegaly with increased splenic FDG uptake is also uncommon in celiac disease in the absence of portal hypertension; small-sized spleen and functional hyposplenism are more typical. We report a case of celiac disease diagnosed after PET/CT showed FDG uptake in the duodenum and enlarged spleen. Follow-up after gluten-free diet showed complete metabolic resolution and regression of splenomegaly. The combination of focal bowel and splenic uptake is unusual in celiac disease and may be mistaken for a lymphoproliferative disorder. Awareness of this entity may avoid misdiagnosis and guide appropriate management. | ||
| کلیدواژهها | ||
| Celiac disease؛ Splenomegaly؛ 18F-FDG PET/CT؛ Incidental bowel uptake؛ Lymphoma | ||
| مراجع | ||
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