Sentinel lymph node biopsy for papillary thyroid cancer: the effect of dose, tracer and application of massage | ||
| Asia Oceania Journal of Nuclear Medicine and Biology | ||
| مقاله 2، دوره 9، شماره 1، فروردین 2021، صفحه 9-14 اصل مقاله (834.13 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/aojnmb.2020.50491.1345 | ||
| نویسندگان | ||
| Abbas Alibakhshi1؛ Saeed Farzanehfar2؛ Mahya Zarei3؛ Mohammad Eftekhari3؛ Maziar Motiee4؛ Maryam Naseri2؛ Mehrshad Abbasi* 2 | ||
| 1Department of surgery, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Department of Otolaryngology–Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. | ||
| چکیده | ||
| Objective(s): In patients with papillary thyroid cancer (PTC), sentinel lymph node (SLN) radio-guided biopsy is not routinely used for detection of involved neck lymph nodes (NLN); 99mTc- antimony sulfide colloid (99mTc- ASC) has been used for this purpose. In this study, besides 99mTc-ASC another radiotracer, 99mTc-phytate (99mTc-P) with different doses and injection methods were evaluated. Methods: Twenty-two patients, scheduled to undergo thyroidectomy for PTC, were injected for radio-guided SLN biopsy in the morning of operation in 3 groups: intra tumoral injection of about 1 mCi 99mTc-P (group A; n=5); peritumoral injection of less than 3 mCi 99mTc-ASC (group B; n=6); and peritumoral injection of 3 to 5 mCi 99mTc-ASC with application of massage (group C; n=9). A patient refused to complete the study. A patient with follicular thyroid cancer was also excluded. No NLN was detected in the pre-operative ultra-sonographic examinations of all patients. Central neck dissection was done for all the participants. The presence of radio guided detected NLN and results of pathology were assessed. Results: In group A and B, no SLN was detected. NLNs were resected in 4 patients in group A and B; 2 of them involved by the tumor. In group C, 6 out of 9 patients (66.7%) had between 1 to 6 SLNs; the procedure failed to detect NLN in a patient in group C with surgically resected reactive NLN (failure rate 1 out of 7). Conclusion: The results underscored the significance of SLN radio guided biopsy in patients with PTC; the radiotracer, dose and method of injection may affect the detection rate. | ||
| کلیدواژهها | ||
| Sentinel lymph node biopsy؛ Thyroidectomy؛ Papillary thyroid cancer | ||
| مراجع | ||
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