Mashayekhi-sardoo, Habibeh, Razavi, Bibi Marjan, Ekhtiari, Maryam, Kheradmand, Negar, Imenshahidi, Mohsen. (1399). Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats. , 23(12), 1639-1646. doi: 10.22038/ijbms.2020.44341.10377
Habibeh Mashayekhi-sardoo; Bibi Marjan Razavi; Maryam Ekhtiari; Negar Kheradmand; Mohsen Imenshahidi. "Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats". , 23, 12, 1399, 1639-1646. doi: 10.22038/ijbms.2020.44341.10377
Mashayekhi-sardoo, Habibeh, Razavi, Bibi Marjan, Ekhtiari, Maryam, Kheradmand, Negar, Imenshahidi, Mohsen. (1399). 'Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats', , 23(12), pp. 1639-1646. doi: 10.22038/ijbms.2020.44341.10377
Mashayekhi-sardoo, Habibeh, Razavi, Bibi Marjan, Ekhtiari, Maryam, Kheradmand, Negar, Imenshahidi, Mohsen. Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats. , 1399; 23(12): 1639-1646. doi: 10.22038/ijbms.2020.44341.10377

Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats

Iranian Journal of Basic Medical Sciences
مقاله 17، دوره 23، شماره 12، اسفند 2020، صفحه 1639-1646    اصل مقاله (627.52 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.44341.10377
نویسندگان
Habibeh Mashayekhi-sardoo1؛ Bibi Marjan Razavi2؛ Maryam Ekhtiari1؛ Negar Kheradmand1؛ Mohsen Imenshahidi* 1، 3
1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Regarding Lemon verbena gastroprotective effects, we investigated the protective effects of Lemon verbena extracts on reducing gastric ulcer induced by indomethacin.
Materials and Methods: Rats received aqueous and ethanolic extracts of Lemon verbena (50, 100, and 200 mg/kg), zileuton (100 mg/kg), montelukast (10 mg/kg), or 1% Tween 80 in presence or absence of indomethacin (100 mg/kg).
Results: Indomethacin produced stomach ulcer and increased neutrophils percentage and MDA level compared with the control group (p <0.001). Co-administration of indomethacin and zileuton, montelukast and ethanolic (200 mg/kg) (p <0.001), aqueous extract (200 mg/kg) (p <0.05) reduced ulcer compared with the indomethacin group (p <0.001). Ethanolic extracts (100 and 200 mg/kg) and aqueous extract (200 mg/kg) reduced the MDA level (p <0.001). Ethanolic (50, 100, and 200 mg/kg) and aqueous extracts (200 mg/kg) significantly decreased neutrophils percentage compared with the indomethacin group (p <0.001).
Conclusion: Aqueous and particularly ethanolic extracts of Lemon verbena have protective effects on indomethacin-induced gastric ulcers.
کلیدواژه‌ها
Indomethacin؛ Lemon verbena؛ Lippia citriodora؛ Gastric ulcer؛ NSAIDs
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