Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats | ||
Iranian Journal of Basic Medical Sciences | ||
مقاله 17، دوره 23، شماره 12، اسفند 2020، صفحه 1639-1646 اصل مقاله (627.52 K) | ||
نوع مقاله: Short Communication | ||
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.44341.10377 | ||
نویسندگان | ||
Habibeh Mashayekhi-sardoo1؛ Bibi Marjan Razavi2؛ Maryam Ekhtiari1؛ Negar Kheradmand1؛ Mohsen Imenshahidi* 1، 3 | ||
1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
2Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
3Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran | ||
چکیده | ||
Objective(s): Regarding Lemon verbena gastroprotective effects, we investigated the protective effects of Lemon verbena extracts on reducing gastric ulcer induced by indomethacin. Materials and Methods: Rats received aqueous and ethanolic extracts of Lemon verbena (50, 100, and 200 mg/kg), zileuton (100 mg/kg), montelukast (10 mg/kg), or 1% Tween 80 in presence or absence of indomethacin (100 mg/kg). Results: Indomethacin produced stomach ulcer and increased neutrophils percentage and MDA level compared with the control group (p <0.001). Co-administration of indomethacin and zileuton, montelukast and ethanolic (200 mg/kg) (p <0.001), aqueous extract (200 mg/kg) (p <0.05) reduced ulcer compared with the indomethacin group (p <0.001). Ethanolic extracts (100 and 200 mg/kg) and aqueous extract (200 mg/kg) reduced the MDA level (p <0.001). Ethanolic (50, 100, and 200 mg/kg) and aqueous extracts (200 mg/kg) significantly decreased neutrophils percentage compared with the indomethacin group (p <0.001). Conclusion: Aqueous and particularly ethanolic extracts of Lemon verbena have protective effects on indomethacin-induced gastric ulcers. | ||
کلیدواژهها | ||
Indomethacin؛ Lemon verbena؛ Lippia citriodora؛ Gastric ulcer؛ NSAIDs | ||
مراجع | ||
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