Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst. | ||
| Avicenna Journal of Phytomedicine | ||
| دوره 11، شماره 2، خرداد و تیر 2021، صفحه 101-108 اصل مقاله (674.87 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2020.16718 | ||
| نویسندگان | ||
| María C. Columba-Palomares1؛ Rosa Mariana Montiel-Ruiz2؛ Lucia Corona Sánchez1؛ Daniel Palafox-Gante1؛ Verónica Rodríguez-López* 1 | ||
| 1Laboratory of Chemistry of Natural Products and Pharmacognosy, Faculty of Pharmacy, Autonomous University of the State of Morelos (UAEM). Morelos, México. | ||
| 2Laboratory of Pharmacology, Center of Biomedical Research of the South, Mexican Institute of Social Security (IMSS). Morelos, México. | ||
| چکیده | ||
| Objective: Some species of the Russelia genus have been used different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and antioxidant capacity of methanol and dichloromethane extracts of Russelia coccinea. Materials and Methods: In this study, topical anti-inflammatory activity was tested in an in vivo model of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema of organic extracts (doses: 0.03, 0.1, and 0.3 mg/ear). The antinociceptive activity was assessed using the formalin test in mice of organic extracts (doses: 56, 100 and 300 mg/kg ). Moreover, the antioxidant capacity of the extracts was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiaziline-6-sulfonate) (ABTS) and ferric reducing antioxidant power (FRAP) assays. Results: Methanol (RcM) and dichloromethane (RcD) extracts of the R. coccinea aerial parts were found to inhibit ear edema (48.95 and 40.13%, respectively) at a dose of 0.3 mg/ear. Acute treatment with RcM produced a significant antinociceptive effect in the late phase of formalin-induced nociception. Moreover, RcM at doses of 56, 100 and 300 mg/kg showed a significant antinociceptive effect through the early and late phases in the formalin test. RcM and RcD showed weak antioxidant capacities in the ABTS and DPPH assays; however, when their reducing capacity was evaluated by the FRAP assay, RcM showed a reducing activity similar to Camellia sinensis standard at the proven concentration of 1000 μg/ml. Conclusion: According to the experimental findings, the organic extracts of R. coccinea display remarkable antinociceptive and anti-inflammatory activities. | ||
| کلیدواژهها | ||
| Russelia coccinea؛ Plantaginaceae؛ Anti-inflammatory activity؛ Antinociceptive activity؛ Organic extracts؛ Antioxidant | ||
| مراجع | ||
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