The effect of ginger (Zingiber officinale) feed on cardiac biomarker in medium-dose isoproterenol-induced myocardial toxicity | ||
Avicenna Journal of Phytomedicine | ||
مقاله 1، دوره 11، شماره 1، فروردین و اردیبهشت 2021، صفحه 1-10 اصل مقاله (382.19 K) | ||
نوع مقاله: Short communication | ||
شناسه دیجیتال (DOI): 10.22038/ajp.2020.16699 | ||
نویسندگان | ||
Alaba Ojo* 1؛ Olufemi Oluranti1؛ Lawrence Adedayo1؛ Olatunbosun Onaseso1؛ Timothy Emmanuel1؛ Omowumi Ekomaye1؛ Marvellous Owoade1؛ Abiodun Ayoka2 | ||
1Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria | ||
2Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile- Ife | ||
چکیده | ||
Objectives- Traditional medicines have been widely used to prevent and treat diseases for thousands of years. This study was designed to evaluate the effect of ginger feed on cardiac biomarker in isoproterenol induced myocardial toxicity. Materials and Methods- Thirty male wistar rats were grouped into six groups of 5 rats each: Control; ISO- induced toxicity; ginger fed ; ginger fed before; ginger fed+ isoproterenol simultaneously and ginger fed after. Freshly prepared solution of isoproterenol was injected subcutaneously at a dosage of 20mg/kg, while the control recieved distilled water. Blood was collected via cardiac puncture after two weeks of administration, the serum was used to evaluate biomarkers. Results- The CK-MB of ginger fed groups was significantly lower (p < 0.05) compared to ISO group(8.2 ± 0.5µ/L). The CK of the ginger fed groups showed significant decrease (p>0.05) compared to isoproterenol group (39.36±5.28 µ/L), there was no significant difference in the CK-MB and CK levels of all the groups fed with ginger compared to the control(2.2± 0.3µ/L; 17. 07 ± 3.4.90 µ/L) except the group that was fed with ginger after isoproterenol induction, which was significantly higher compared to the control(p>0.05). The mean value of LDH were lower in all ginger treated groups compared to the ISO group (67.17± 0.88; p≤ 0.05), but significantly higher (p < 0.05) compared to the control(26.45 ± 2.52). The mean value of ALT were lower in all ginger fed groups compared to the ISO group (83.11± 4.88; p ≤ 0.05). Conclusion- Ginger feed hindered toxic effects of isoproterenol. | ||
کلیدواژهها | ||
CK-MB؛ LDH؛ ALT؛ creatine kinase؛ cardioprotective | ||
مراجع | ||
National Research Council. 2011. (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals.Washington (DC): National Academies Press (US); .8th edition. Apple FS. 1992. Diagnostic markers for detection of acute myocardial infarction and reperfusion. Lab Med, 23: 297-322. Heraldo GLF, Nestor LF, Rafael BS, Eduardo RC, Patrícia LDL. 2011. Experimental model of myocardial infarction induced by isoproterenol in rats. Rev Bras Cir Cardiovasc, 26:469-476 Acikel M, Buyukokuroglu ME, Erdogan F, Aksoy H, Bozkurt E, Senocak H. 2005. Protective effects of dantrolene against myocardial injury induced by isoproterenol in rats: biochemical and histological findings. Int J Cardiol, 98: 389-94. Ojha S,Jagriti B, Sachin A, Mahaveer G, Santosh K, Dharamvir SA. 2011. Cardioprotective effects of Commiphora mukul against isoprenaline-induced cardiotoxicity: A biochemical and istopathological evaluation. J Environ Biol, 32: 731-738. Adams JE, Abendschein DR, Jaffe AS .1993. Biochemical markers of myocardial injury: Is MB Creatine kinase the choice for the 1990? Circulation, 88: 750-763. Murray CJL, LopeA DZ. 1997. Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet, 349: 1498–1504. Rajadurai M, Prince P.S. (2007): “Preventive effect of narginin on cardiac mitochondrial enzymes during isoproterenol-induced myocardial infarction in rats: a transmission electron microscopic study. J of Biochem Ginger feed attenuates iso-induced toxicity AJP, Vol. 11, No. 1, Jan-Feb 2021 9 and Molecu Toxicol, 21: 354–361. Saravanan G, Ponmurugan P, Sathiyavathi M, Vadivukkarasi S, Sengottuvelu S. 2013. Cardioprotective activity of Amaranthus viridis Linn: effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats. Int J Cardio, 165: 494–498. Priscilla DH, Prince PSM. 2009. Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats,” Chemico-Biol Interact,179: 118–124. Amano S, Arai M, Goto S, Togari A. 2007. Inhibitory effect of NPY on isoprenalineinduced osteoclastogenesis in mouse bone marrow cells. Biochem Biophys Acta, 1770: 966- 973. Helal EGE, El-Wahab SMA, Sharaf AMM, Zedan GA. 2012. Effect of Zingiber officinale on fatty liver induced by oxytetracycline in albino rats. Egyp J Hosp Med, 46: 26-42. Wang Q, Xiao-feng Y, Hua-li X, Yi-chuan J, Xue-zhong Z, and Da-yuan S. 2018. Ginsenoside Re Attenuates IsoproterenolInduced Myocardial Injury in Rats Evidence-Based Compl Alter Med, 2018: 1- 9. Tasatargil A, Kuscu N, Dalaklioglu S. 2017. Cardioprotective effect of nesfatin-1 against isoproterenol-induced myocardial infarction in rats: Role of the Akt/GSK-3𝛽 pathway. Peptides, 95: 1–9. Peer PA, Trivedi PC, Nigade PB, Ghaisas MM, Deshpande AD. 2008 Cardioprotective effect of Azadirachta indica A. Juss. on isoprenaline induced myocardial infarction in rats. Int J Cardiol, 26: 123-126. Akila P, Asaikumar L, Vennila L. 2017. Chlorogenic acid ameliorates isoproterenolinduced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes. Biomed Pharmacother. 85: 582- 591. Shukla Y, Singh M. 2007. Cancer preventive properties of ginger: a brief review. Food Chem Toxicol; 45: 683-90. Afzal M, Al-hadidi D, Menon M, Pesek J, Dhami MS. 2011. Ginger: An Ethnomedical, Chemical and Pharmacological Review. Drug Interact, 18: 159-190. Duke JA, Ayensu ES. 1997. Medicinal Plants of China. Medicinal Plants of the World. Algonac, MI: Reference Publications, USA, pp. 362. Ithayarasi AP, Devi CS. Indian J Physiol Pharmacol, 41: 369-376. Glick MR, Ryder KW, Jackson SA. 1986. Graphical Comparisons of Interferences in Clinical Chemistry lnstrumentation. Clin Chem, 32: 470-474. Athirah ZA, Ibrahim J, Roza D, and Fhataheya B. Protective effects of the standardized extract of Zingiber officinale on myocardium against isoproterenol-induced biochemical and histopathological alterations in rats. Pharm Biol, 53: 1795- 1802. Duan L, Xiong X, Hu J, Liu Y, Li J, and Wang J. 2017. “Panax notoginseng saponins for treating coronary artery disease: A functional and mechanistic overview,” Frontiers Pharmacol, 8: 702. Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN. Comparative antioxidant and antiinflammatory effectsof [6]-gingerol, [8]- gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol, 2010; 127: 515-20. Shanmugam KR, Mallikarjuna K, Sathyavelu Reddy K. Efficacy of ethanolic extract of ginger on kidney lipid metabolic profiles in diabetic rats. Int J Diabetes Dev Ctries, 2011; 31: 97-103. Ansari MN, Bhandari U, Pillai KK. 2006. Ethanolic Zingiber officinale R extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats. I J Expl Bio, 44: 892-7. Raish M. 2017. Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-κB signaling pathway. Int J Biol Macromol; 97: 544-551. Roth GA, Abate D, Abate KH et al.(2018). Global, regional, and national age-sexspecific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392: 1736- 1788 Woudstra L, Biesbroek PS, Emmens RW, Heymans S, Juffermans LJ, van Rossum AC. 2017. Lymphocytic myocarditis occurs Olumide Ojo et al. AJP, Vol. 11, No. 1, Jan-Feb 2021 10 with myocardial infarction and coincides with increased inflammation, hemorrhage and instability in coronary artery atherosclerotic plaques. Int J Cardio, 232: 53-62. Long J, Gao M, Kong Y, Shen X, Du X, Son YO, et al. 2012. Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine, 19: 672-676. Awada HK, Johnson NR, Wang Y. Sequential delivery of angiogenic growth factors improves revascularization and heart function after myocardial infarction. J Contr. Relea, 2015; 207: 7-17. Subbaiah GV, Mallikarjuna K, Shanmugam B, Ravi S, Taj PU, Reddy KS. 2017. Ginger treatment ameliorates alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers in rats. Phcog Mag, 13: 69-75. Kaplan, L.A., Pesce, AJ. 1989. Clinical Chemistry, St. Louis, C.V. Mosby, pp. 911- 912. Mansour A, Bakheet SA, Aleisa AM, Al-Rejaie SS, AL-Yahya AA, ElAmeen M, et al. Protective Effect of 6-Gingerol Against cardiotoxicity Induced by Doxorubicin. Open Pharmacol J, 2: 20-3. Attyah AM, Ismail SH. 2008. Protective effect of ginger extract against cisplatin-induced hepatotoxicity and cardiotoxicity in rats. Iraqi J Pharm Sci, 2012; 21: 27-33. Ansari MN, Bhandari U, Pillai KK. 2006. Ethanolic Zingiber officinale R extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats. I J Expl Bio; 44: 892-7. Siddiqui MA, Ahmad U, Khan AA, Badruddeen AM, Khalid M, Akhtar J. 2016. Isoprenaline: A Tool for Inducing Myocardial Infarction in Experimental Animals. Int J Pharm. 6: 138-144. Whellan DJ. 2005. Heart failure disease management: implementation and outcomes. Cardiol Rev, 13: 231-39. McGill R.M. (2016). The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J, 15: 817– 828. Krushna G, Kareem MA, Devi KL. 2009. Antidyslipidaemic effect of Aegle marmelos Linn. Fruit on isoproterenol induced myocardial injury in rats. Int J Pharmacol, 6: 1-5. Tietz, NW. 1982. Fundamentals of Clinical Chemistry, W.B. Saunders co., p 674. Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology. 1974. Scand J Clin Lab Invest, 32:291. United Nations(2015).Transforming our world: the 2030 agenda for sustainable development. https://www.un.org/ga/search/view_doc.asp ?symbol=A/RES/70/1&Lang=E.2015 Zhang GX, Kimura S, Nishiyama A, Shokoji T, Rahman M, Yao L, Nagai Y, Fujisawa Y, Miyatake A, Abe Y. (2005). Cardiac oxidative stress in acute and chronic isoproterenol-infused rats. Cardiovasc Res, 65: 230-238. | ||
آمار تعداد مشاهده مقاله: 11,527 تعداد دریافت فایل اصل مقاله: 3,386 |