Maternal Voluntary Exercise during Pregnancy Enhances the Spatial Learning Acquisition but not the Retention of Memory in Rat Pups via a TrkB-mediated Mechanism: The Role of Hippocampal BDNF Expression | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 1، دوره 16، شماره 9، آذر 2013، صفحه 955-961 اصل مقاله (556.82 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.1663 | ||
| نویسندگان | ||
| Maziar M Akhavan1؛ Hossein Miladi-Gorji* 2؛ Mitra Emami-Abarghoie3؛ Manouchehr Safari4؛ Bizhan Sadighi-Moghaddam5؛ Abbas A. Vafaei2؛ Ali Rashidy-Pour2 | ||
| 1Skin Research Center, Laboratory of Protein and Enzyme, Shahid Beheshti University (M.C), Shohada-e Tajrish Hospital, Shahrdari St, Tehran, Iran,Department of Pharmacology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran | ||
| 2Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran | ||
| 3Department of Pharmacology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran | ||
| 4Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran | ||
| 5Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran | ||
| چکیده | ||
| Objective(s): The effect of maternal voluntary exercise on hippocampal BDNF level in rat offspring was studied. In addition, the possible role of hippocampal BDNF receptors in maternal exercise induced enhancement of learning in the rat pups was investigated. Materials and Methods: Pregnant rats have been randomly assigned to sedentary control or voluntary exercise groups. Each of the exercising pregnant rats was given access to a cage that was equipped with a running wheel until the end of their pregnancy. On post natal day (PND) 36, two groups consisted of 7 male rat pups in each group from sedentary or exercised mothers were sacrificed and the hippocampus was dissected for BDNF proteins level determination. Also, bilateral injection of K252a to the hippocampus was used to block the hippocampal BDNF action on PND59 in the rat pups. Results: Voluntary exercise during pregnancy significantly increased the level of BDNF protein in the hippocampus of the rat pups on PND36 compared to the control group (P=0.048). Inhibiting BDNF action abolished the exercise-induced improvement of learning acquisition in offspring in training trials (P=0.0001). No difference was observed in the platform location latency and the time spent in the target in the probe test between two groups. Conclusion : This study demonstrates that voluntary exercise during pregnancy via a TrkB-mediated mechanism enhances the spatial learning acquisition, however, not the retention of memory in the rat pups. | ||
| کلیدواژهها | ||
| BDNF Hippocampus K252a Memory TrkB Offspring Voluntary exercise | ||
| مراجع | ||
|
1. Coles K, Tomporowski PD. Effects of acute exercise on executive processing, short-term and long-term memory. J Sport Sci 2008; 26: 333 – 344.
2. Van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999; 2: 266-270.
3. Akhavan MM, Foroutan T, Safari M, Sadighi-Moghaddam B, Emami-Abarghoie M, Rashidy-Pour A. Prenatal exposure to maternal voluntary exercise during pregnancy provides protection against mild chronic postnatal hypoxia in rat offspring. Pak J Pharm Sci 2012; 25: 233-238.
4. Akhavan MM, Emami-Abarghoie M, Safari M, Sadighi-Moghaddam B, Vafaei AA, Bandegi, AR, et al. Serotonergic and noradrenergic lesion suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups. Neuroscience 2008; 151: 1173–1183.
5. Kim H, Lee SH, Kim SS, Yoo JH, Kim CJ. The influence of maternal treadmill running during pregnancy on short-term memory and hippocampal cell survival in rat pups. Int J Dev Neurosci 2007; 25: 243–249.
6. Lee HH, Kim H, Lee JW, Kim YS, Yang HY, Chang HK, et al. Maternal swimming during pregnancy enhances short-term memory and neurogenesis in the hippocampus of rat pups. Brain Dev 2006; 28: 147–154.
7. Parnpiansil P, Jutapakdeegul N, Chentanez T, Kotchabhakdi N. Exercise during pregnancy increases hippocampal brain-derived neurotrophic factor mRNA expression and spatial learning in neonatal rat pup. Neurosci Lett 2003; 352: 45–48.
8. Bick-Sander A, Steiner B, Wolf SA, Babu H, Kempermann G. Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring. Proc Natl Acad Sci USA 2006; 103: 3852-3857.
9. O’Callaghan RM, Ohle R, Kelly AM. The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning. Behav Brain Res 2007; 176:362–366.
10. Stranahan AM, Zhou Y, Martin B, Maudsley S. Pharmacomimetics of exercise: Novel approaches for hippocampally-targeted neuroprotective agents. Curr Med Chem 2009; 16: 4668-4678.
11. van Praag H, Shubert T, Zhao C, Gage FH. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci, 2005; 25, 8680–8685.
12. Van Praag H. Neurogenesis and exercise: Past and future directions. Neuromolecular Med 2008; 10:128–140.
13. Ding Q, Vaynman S, Akhavan MM, Ying Z, Gomez – Pinilla F. Insulin- like growth factor 1 interfaces with brain -derived neurotrophic factor - mediated synaptic plasticity to modulate aspects of exercise - induced cognitive function. Neuroscience 2006; 140: 823–833.
14. Neeper SA, Gomez-pinilla F, Choi J, Cotman CW. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 1996; 726: 49-56.
15. Vaynman S,Ying Z, Gomez-Pinilla F. Interplay between BDNF and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience 2003; 122:647–657.
16. Kafitz KW, Rose CR, Thoenen H, Konnerth A. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature 1999; 401: 918-921.
The Role of Hippocampal BDNF Expression Akhavan et al
Iran J Basic Med Sci, Vol. 16, No. 9, Sep 2013
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17. Akhavan MM, Emami-Abarghoie M, Sadighi-Moghaddam B, Safari M, Yousefi Y, Rashidy-Pour A. Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat. Brain Res 2008; 1232: 132-138.
18. Lom B, Cohen-Cory S. Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. J Neurosci 1999; 19: 9928–9938.
19. Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 2004; 20: 2580- 2590.
20. Miladi-Gorji H, Rashidy-Pour A, Fathollahi Y, Akhavan MM, Semnanian S, Safari M. Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: The role of hippocampal brain-derived neurotrophic factor. Neurobiol learn mem 2011; 96: 479-491.
21. Vaynman S, Ying Z, Gَmez-Pinilla F. Exercise induces BDNF and synapsin I to specific hippocampal subfields. J Neurosci Res 2004;76: 356-362.
22. Ebrahimi S, Rashidy-Pour A,Vafaei AA, Akhavan MM. Central β-adrenergic receptors play an important role in the enhancing effect of voluntary
exercise on learning and memory in rat. Behav Brain Res 2010; 208:189–193.
23. Adlard PA, Cotman CW. Voluntary exercise protects against stress - induced decreases in brain - derived neurotrohic factor protein expression. Neuroscience 2004; 124: 985–992.
24. Fujioka A, Fujioka T, Ishida Y, Maekawa T, Nakamura S.Differential effects of prenatal stress on the morphological maturation of hippocampal neurons. Neuroscience 2006; 141: 907–915.
25. Van den Hove DL, Lauder JM, Steepens A, Prickaerts J, Blanco CE, Steinbusch HW. Prenatal stress in the rat alters 5-HT1A receptor binding in the ventral hippocampus. Brain Res 2006; 1090: 29-34.
26. Holmes MM, Galea LA, Mistlberger RE, Kempermann G. Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effects. J Neurosci Res 2004; 76: 216-22.
27. Knüsel B, Hefti F. K-252 compounds: modulators of neurotrophin signal transduction. J Neurochem 1992; 59: 1987-96.
28. Skup M, Czarkowska-Bauch J, Dwornik A, Macias M, Sulejczak D, Wiater M. Locomotion induces changes in Trk B receptors in small diameter cells of the spinal cord. Acta Neurobiol Exp (Wars). 2000; 60: 371. | ||
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