سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mahdian, Davoud, Abbaszadeh-Goudarzi, Kazem, Raoofi, Amir, Dadashizadeh, Ghazaleh, Abroudi, Mina, Zarepour, Elahe, Hosseinzadeh, Hossein. (1399). Effect of Boswellia species on the metabolic syndrome: A review. , 23(11), 1374-1381. doi: 10.22038/ijbms.2020.42115.9957
Davoud Mahdian; Kazem Abbaszadeh-Goudarzi; Amir Raoofi; Ghazaleh Dadashizadeh; Mina Abroudi; Elahe Zarepour; Hossein Hosseinzadeh. "Effect of Boswellia species on the metabolic syndrome: A review". , 23, 11, 1399, 1374-1381. doi: 10.22038/ijbms.2020.42115.9957
Mahdian, Davoud, Abbaszadeh-Goudarzi, Kazem, Raoofi, Amir, Dadashizadeh, Ghazaleh, Abroudi, Mina, Zarepour, Elahe, Hosseinzadeh, Hossein. (1399). 'Effect of Boswellia species on the metabolic syndrome: A review', , 23(11), pp. 1374-1381. doi: 10.22038/ijbms.2020.42115.9957
Mahdian, Davoud, Abbaszadeh-Goudarzi, Kazem, Raoofi, Amir, Dadashizadeh, Ghazaleh, Abroudi, Mina, Zarepour, Elahe, Hosseinzadeh, Hossein. Effect of Boswellia species on the metabolic syndrome: A review. , 1399; 23(11): 1374-1381. doi: 10.22038/ijbms.2020.42115.9957

Effect of Boswellia species on the metabolic syndrome: A review

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 23، شماره 11، بهمن 2020، صفحه 1374-1381    اصل مقاله (550.94 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.42115.9957
نویسندگان
Davoud Mahdian1، 2؛ Kazem Abbaszadeh-Goudarzi1؛ Amir Raoofi1؛ Ghazaleh Dadashizadeh1؛ Mina Abroudi1؛ Elahe Zarepour1؛ Hossein Hosseinzadeh* 3، 4
1Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
2Department of Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
3Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
The metabolic syndrome, a cluster of metabolic disorders, includes abdominal obesity, hypertension, dyslipidemia, and hyperglycemia leading to insulin resistance, development of diabetes mellitus, and cardiovascular diseases. For the treatment of metabolic syndrome, traditional herbal medicines such as frankincense or Boswellia species have been used due to their anti-inflammatory, anti-oxidant, anti-obesity, antidiabetic, antihypertensive, and hypolipidemic properties. Based on the literature, published evidence up to 2020 about the therapeutic effects of Boswellia species  on the metabolic disorder among Medline, Scopus, and Google Scholar were precisely evaluated by keywords such as obesity, diabetes, hyperglycemia, hypertension, blood pressure, dyslipidemia, metabolic syndrome, frankincense, and Boswellia. According to the results, Boswellia species  have beneficial effects to control metabolic syndrome and its related disorders such as hyperglycemia, dyslipidemia, hypertension, obesity, diabetes, and its complications. Boswellia species  by reducing the resistance to insulin and restoring pancreatic beta cells decrease blood glucose. Also, Boswellia species  has antithrombotic and anticoagulant properties that regulate blood pressure. The anti-oxidant properties of Boswellia species  modulate the blood lipid profile via reducing TNF-α, IL-1β levels, and increasing the adiponectin level. The therapeutic and protective effects of Boswellia species  on metabolic disorders were remarkably confirmed regarding decreasing hyperglycemia, hyperlipidemia, hypertension, and obesity.
کلیدواژه‌ها
Hyperglycemia؛ Hypertension؛ Dyslipidemia؛ Metabolic syndrome؛ Frankincense؛ Olibanum؛ Boswellia
مراجع
1.    Akaberi M, Hosseinzadeh H. Grapes (Vitis vinifera) as a potential candidate for the therapy of the metabolic syndrome. Phytother Res 2016; 30:540-556.
2.    Hassani FV, Shirani K, Hosseinzadeh H. Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review. Naunyn Schmiedebergs Arch Pharmacol 2016;389:931-949.
3.    Sanati S, Razavi BM, Hosseinzadeh H. A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome. Iran J Basic Med Sci 2018; 21:439-448.
4.    Tabeshpour J, Imenshahidi M, Hosseinzadeh H. A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome. Iran J Basic Med Sci 2017; 20:557-568.
5.    Razavi BM, Hosseinzadeh H. Saffron: a promising natural medicine in the treatment of metabolic syndrome. J Sci Food Agric 2017; 97:1679–1685.
6.    Mollazadeh H, Mahdian D, Hosseinzadeh H. Medicinal plants in treatment of hypertriglyceridemia: a review based on their mechanisms and effectiveness. Phytomedicine 2019; 53:43-52.
7.    Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol 2010; 16:4504–4514.
8.    Tajmohammadi A, Razavi BM, Hosseinzadeh H. Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: a review. Phytother Res 2018;32:1933-1949.
9.    Tousian Shandiz H, Razavi BM, Hosseinzadeh H. Review of Garcinia mangostana and its xanthones in metabolic syndrome and related complications. Phytother Res. 2017;31:1173-1182
10.    Mollazadeh H, Hosseinzadeh H. Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iran J Basic Med Sci 2016;19:1258-1270.
11.    Hosseini S, Jamshidi L, Mehrzadi S, et al. Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebocontrolled clinical trial. J Ethnopharmacol 2014; 152:451–456.
12.    Razavi BM, Hosseinzadeh H. A review of the effects of Citrus paradise (grapefruit) and its flavonoids, naringin, and naringenin in metabolic syndrome. In Bioactive food as dietary interventions for diabetes (sec edition). Eds. Watson, R. R. and Preedy, V.R. 2019, Chp.43, 515-543, London.
13.    Forouzanfar F, Hosseinzadeh H, Ebrahimzadeh Bideskan A, Sadeghnia HR. Aqueous and ethanolic extracts of Boswellia serrata protect against focal cerebral ischemia and reperfusion injury in rats., Phytother Res 30, 1954-1967.
14.    Woolley CL, Suhail MM, Smith BL, Boren KE, Taylor LC, Schreuder MF, et al. Chemical differentiation of Boswellia sacra and Boswellia carterii essential oils by gas chromatography and chiral gas chromatography-mass spectrometry. J Chromatogr A 2012; 1261: 158-163.
15.    De Rapper S, Van Vuuren SF, Kamatou GP, Viljoen AM, Dagne E. The additive and synergistic antimicrobial effects of select frankincense and myrrh oils-a combination from the pharaonic pharmacopoeia. Lett Appl Microbiol 2012; 54: 352-358.
16.    Blain EJ, Ali AY, Duance VC. Boswellia frereana (frankincense) suppresses cytokine-induc ed matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytother Res 2010; 24: 905-912.
17.    Devi PR, Adilaxmamma K, Rao GS, Srilatha Ch, Raj MA. Safety evaluation of alcoholic extract of Boswellia ovalifoliolata stembark in rats. Toxicol Int 2012; 19: 115-120.
18.    Ebrahimpour S, Fazeli M, Mehri S, Taherianfard M, Hosseinzadeh H. Boswellic acid improves cognitive function in a rat model through its antioxidant activity: Neuroprotective effect of boswellic acid. J Pharmacopuncture 2017;20:10-17.
19.    Zutshi U, Rao PG, Ravi S, Singh GB, Surjeet S, Atal CK. Mechanism of cholesterol lowering effect of Salai guggal ex. Boswellia serrata roxb. Indian J Pharmacol 1986;18: 182–183.
20.    Rao AR, Veeresham C, Asres K. In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. Phytother Res. 2013; 27: 753–760.
21.    Ahangarpour A, Heidari H, Fatemeh RA, et al. Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients. J Diabetes Metab Disord. 2014;13:29.
22.    Ahangarpour A, Akbari Fatemeh Ramezani A, Heidari H, et al. The effect of Boswellia serrata on blood glucose, insulin level and insulin resistance in type 2 diabetic patients. Daneshvar Med. 2013;20:11–18.
23.    Sharma A, Upadhyay J, Jain A, Namdeo A,  Mahadik  KR. Antioxidant activity of aqueous extract of Boswellia serrata. J.Chem.Bio.Phy.Sci. 2011,1: 60-71.
24.    Al-Awadi F, Fatania H, Shamte U: The effect of a plants mixture extract on liver gluconeogenesis in streptozocin induced diabetic rats. Diabetes Res 1991, 18:163–168.
25.    Pandey RS, Singh BK, Tripathi YB: Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property. Indian J Exp Biol 2005, 43:509–516.
26.    Senghani MK, Patel PM. Pharmacognostic and phytochemical study of Oleo gum resin from Boswellia serrata. Res J Pharmacog Phytochem 2013; 5: 244-250.
27.    Gerbeth K, Meins J, Kirste S, Momm F, Schubert-Zsilavecz M, Abdel-Tawab M. Determination of major boswellic acid in plasma by high-pressure liquid chromatography/mass spectrometry. J Pharm Biomed Anal 2011; 56: 998-1005.
28.    Al-Harrasi A, Ali L, Rehman NU, Hussain H, Hussain J, Al- Rawahi A, et al. Nine triterpenes from Boswellia sacra Flückiger and their chemotaxonomic importance. Biochem Syst Ecol 2013; 51: 113-116.
29.    Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med 2006;72:1100-1116.
30.    AlHarrasi A, AlSaidi S. Phytochemical analysis of the essential oil from botanically certified oleogum resin of Boswellia sacra (Omni Luban). Molecules 2008;13:2181-2189.
31.    Shah BA, Qazi GN, Taneja SC. Boswellic acids: a group of medicinally important compounds. Nat Product Rep 2009; 26: 72-89.
32.    Schauss A, Milholland R, Munson S. Indian frankincense (Boswellia serrata) gum resin extract: a review of therapeutic applications and toxicology. Nat Med J 1999; 2: 16-20.
33.    Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. 2011;73:255-261.
34.    Sferra R, Vetuschi A, Catitti V, Ammanniti S, Pompili S, Melideo D, et al. Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation. Eur Rev Med Pharmacol Sci 2012; 16: 1484- 1498.
35.    Khan MA, Singh M, Khan MS, Najmi AK, Ahmad S. Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma. Biomed Res Int 2014; 2014: 294143.
36.    Mohammad Hosein Farzaei, Roja Rahimi, Fatemeh Farzaei and Mohammad Abdollahi. Traditional medicinal herbs for the management of diabetes and its complications: an evidence-based review. Int J Pharmacol 2015;11 : 874-887.
37.    Kokkiripati PK, Bhakshu LM, Marri S, Padmasree K, Row AT, Raghavendra AS, Tetali SD. Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation. J Ethnopharmacol 2011; 1;137:893-901.
38.    Ahmed A. Zaki, Nadia E. Hashish, Mohamed A. Amer, Mohamed-Farid Lahloub. Cardioprotective and anti-oxidant effects of oleogum resin “Olibanum” from Boswellia carteri Birdw. (Bursearceae). Chin J Nat Med 2014;12:345-350.
39.    Shehata AM, Quintanilla-Fend L, Bettio S, Singh CB, Ammon HP. Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE). Phytomedicine 2011; 18: 1037-1044.
40.    Azemi ME, Namjoyan F, Khodayar MJ, Ahmadpour F, Darvish Padok A, Panahi M. The antioxidant capacity and anti-diabetic effect of Boswellia serrata Triana and planch aqueous extract in fertile female diabetic rats and the possible effects on reproduction and histological changes in the liver and kidneys. Jundishapur J Nat Pharm Prod 2012; 7: 168-175.
41.    Alawadi F, Fatania H, Shamte U. The effect of plant mixture extract on liver gluconeogenesis in streptozocin induced diabetic rats. Diabetes Res 1991; 18: 163-168.
42.    Shehata AM, Quintanilla-Fend L, Bettio S, Jauch J, Scior T, Scherbaum WA, et al. 11-Keto-b-boswellic acids prevent development of autoimmune reactions, insulitis and reduce hyperglycemia during induction of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice. Horm Metab Res 2015; 47: 463- 469.
43.    Franić Z, Franić Z, Vrkić N, Gabaj NN, Petek I. Effect of extract from Boswellia serrata gum resin on decrease of GAD65 autoantibodies in a patient with Latent Autoimmune Diabetes in Adults. Altern Ther Health Med 2020; AT6085. Online ahead of print.
44.    Kavitha JV, Rossario JF, Chandran J, Anbu P, Bakkiyanathan. Hypoglycemic and other related effects of Boswellia glabra in alloxaninduced diabetic rats. Indian J Physiol Pharmacol 2007;51: 29-39.
45.    Shehata AM, J Jauch L. Quintanilla-Martinez and H.P.T. Ammon, 2012. 11-Keto-β-boswellic acid inhibits infiltration of lymphocytes into pancreatic islets in NOD-mice. Horm Metab Res 2017;49:693-700.
46.    Al-Yasiry RMA, Jawad SAH3, Menati KJ, Naji SA and Lokman IH. Effects of Boswellia carterii and Boswellia serrata in drinking water on the growth performance, hematology traits and immune response of broiler chicken. Int J Dairy Technol 2016: 4 :27-37.
47.    Al-Daraji J, et al. Effect of supplementation of different levels frankincense to drinking water on certain hematological traits of broiler. J Biol Chem Environ 2013;8:589-601.
48.    Kavitha JV, Rosario JF, Chandran J, Anbu P, Bakkiyanathan. Hypoglycemic and other related effects of Boswellia glabra in alloxan-induced diabetic rats. Indian J Physiol Pharmacol 2007;51:29-39.
49.    Helal EGE, Mostafa AM, Ashour FA, Kahwash AA. Effect of boswellia carterii birdw on carbohydrate metabolism in diabetic male albino rats. Egypt J Hosp Med 2005; 20: 38-45.
50. Boos CJ, Lip GYH. Blood clotting inflammation and thrombosis in cardiovascular events: perspectives. Frontiers in Bioscience 2006; 11: 328–336.
51. Ross R. Atheroscelerosis—an inflammatory disease. N Engl J Med 1999 14;340: 115-126.
52. Assimopoulou AN, Zlatanos SN, Papageorgiou VP. Antioxidant activity of natural resins and bioactive triterpenes in oil substrates. Food Chemistry 2005; 92:721–727.
53. Bushra, S., Farooq, A., Roman, P. Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam. Trees.  Food Chemistry 104:1106-1114.
54. Magesh V, Raman D, Pudupalayam KT. Genotoxicity studies of dry extract of Boswellia serrata. Trop J Pharm Res 2008; 7:1129–1135.
55. Sharma A, Mann A, Gajbhiye V and Kharya M. Phytochemical profile of Boswellia serrata: an overview. Pharmacogn Rev 2007; 1: 137.
56. Singh S, Khajuria A, Taneja S, Johri R, Singh J and Qazi G. Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders. Phytomedicine 2008; 15: 400-407.
57. Yuliana N, Khatib A, Link-Struensee A, Ijzerman A, Rungkat-Zakaria F, Choi Y. Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus. Planta Med 2009; 75: 132- 136.
58. Asif M, Atif M, Amin MS, Zahari CD, Irshad A and Ashfaq A. Diuretic activity of Trianthema portulacastrum crude extract in albino rats. Trop J Pharm Res 2013, 12: 967-972.
59. Horacio J, Adrogue MD, Nicolaos E and Madias MD. Mechanisms of disease. sodium and potassium in the pathogenesis of hypertension. New Eng J Med 2007; 356: 1966-1978.
60. Eisvand F, Razavi BM, Hosseinzadeh H. The effects of Ginkgo biloba on metabolic syndrome: A review. Phytother Res 2020; 34:1798-1811.
61. Zutshi U, Rao PG, Kaur Samagat, Singh GB, Atal CK. Mechanism of cholesterol lowering effect of Salai guggal ex- Boswellia serrata. Indian J Pharm 1980; 12: 59.
62.  Cuaz-P´erolin C, Billiet L, Baug´e E, Copin C, Scott-Algara D, Genze F. Anti-inflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. Arterioscler Thromb Vasc Biol 2008; 28: 272-277.
63. Liu JJ, Toy WC, Liu S, Cheng A, Lim BK, Subramaniam T. Acetyl-keto-b-boswellic acid induces lipolysis in mature adipocytes. Biochem Biophys Res Commun 2013; 431: 192-196.
64. Pandey S, Singh BK, Tripathi YB. Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidernic property. Indian J Exp Biol 2005;43: 509-516.
65. Al-Daraji J, Ahmed AS, Al-Yasery ARM. Effect of supplementation of different levels frankincense to drinking water on certain hematological traits of broiler. J Biol Chem Environ 2013, 8:589-601.
66. Tripathi YB, Reddy MM, Pandey RS, Subhashini J, Tiwari OP, Singh BK, Reddanna P. Anti-inflammatory properties of BHUx, A polyherbal formulation to prevent atherosclerosis. Inflammopharmacology 2004;12:131-152.
67. Altmann A, Poeckel D, Fischer L, Schubert-Zsilavecz M, Steinhilber D, Werz O. Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004 141:223-232.
68. Ventura LL, Fortes NC, Santiago HC, Caliari MV, Gomes MA, Oliveira DR. Obesity-induced diet leads to weight gain, systemic metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in gerbils (Meriones unguiculatus). Peer J 2017 2;5: e2967.
69. Song M, Um J, Jang H, Lee B. Beneficial effect of dietary Ephedra sinica on obesity and glucose intolerance in high-fat diet-fed mice. Exp Ther Med 2012; 3:707–712.
70. Xu BJ, Han LK, Zheng YN, Lee JH, Sung CK. In vitro inhibitory effect of triterpenoidal saponins from Platycodi radix on pancreatic lipase. Arch Pharm Res 28:180–185.
71. Mona Kamal Tawfik. Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades. Arch Med Sci 2016; 12, 6: 1354–1361.
72. Gomaa AA, Farghaly HSM, El-Sers DA, Farrag MM, Al-Zokeim NI. Inhibition of adiposity and related metabolic disturbances by polyphenol‑rich extract of Boswellia serrata gum through alteration of adipo/cytokine profiles. Inflammopharmacology. 2019;27:549-559.
73. Austin C, Stewart D, Allwood JW, McDougall GJ Extracts from the edible seaweed, Ascophyllum nodosum, inhibit lipase activity in vitro: contributions of phenolic and polysaccharide components. Food Funct 2018, 9:502–510.
74. Umar S, Umar K, Sarwar AH, Khan A, Ahmad N, Ahmad S, Katiyar CK, Husain SA, Khan HA, Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine 2014, 21:847–856.
75. Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A. Prospects of boswellic acids as potential pharmaceutics. Planta Med 2015; 81:259–271.
76. Zheng J, DiLorenzo DJ, McLaughlin L, Roberts AT, Greenway FLV. Stimulation of sympathetic innervation in the upper gastrointestinal tract as a treatment for obesity. Med Hypotheses 2009; 72:706–710.
77. Fatima S, Ahmad T, Shahid M et al. Comparative study of Kundur (Boswellia serrata) and Tareeq (Diaphoresis) in the management of Samne Mufrit (Obesity) - a randomised clinical trial. Int J Health Sci Res 2017; 7:186-196.
78. Singh P, Chacko M, Aggarwal ML, Bhat B, Khandal RK, Sultana S, et al.  A 90 day gavage safety assessment of Boswellia serrata in rats. Toxicol Int 2012; 19: 273–278.

آمار
تعداد مشاهده مقاله: 2,471
تعداد دریافت فایل اصل مقاله: 3,359