Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide in rats | ||
Avicenna Journal of Phytomedicine | ||
دوره 11، شماره 1، فروردین و اردیبهشت 2021، صفحه 79-90 اصل مقاله (790.02 K) | ||
نوع مقاله: Original Research Article | ||
شناسه دیجیتال (DOI): 10.22038/ajp.2020.16490 | ||
نویسندگان | ||
Mohammad Javad Azmand1؛ Ziba Rajaei* 2 | ||
1Department of Physiology School of Medicine Isfahan University of Medical Sciences Isfahan, Iran. | ||
2Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
چکیده | ||
Objective: Neuroinflammation and oxidative stress play essential roles in the pathogenesis and progression of neurodegenerative diseases, such as Alzheimer’s disease. Crocin, main active constituent of Crocus sativus L. (saffron), possesses anti-inflammatory, anti-apoptotic and anti-oxidative capacity. The aim of the present study was to investigate the neuroprotective effect of crocin on lipopolysaccharide (LPS)-induced learning and memory deficits and neuroinflammation in rats. Materials and Methods: The animals were randomly classified into four groups, including control, LPS, crocin 50 and crocin 100. The rats were treated with either crocin (50 and 100 mg/kg) or saline for a week. Later, LPS (1 mg/kg, i.p.) or saline was administered, and treatments with crocin or saline were continued for 3 more weeks. The behavioral tasks for spatial and aversive memories were performed by the Morris water maze and passive avoidance tasks from post-injection days 18 to 24. Furthermore, the levels of interleukine-1β, lipid peroxidation and total thiol were assayed in the hippocampus and cerebral cortex. Results: Our results demonstrated that treatment of LPS-treated rats with crocin decreased the escape latency in the Morris water maze and increased the time spent in the target quadrant in the probe trial. Moreover, crocin increased step-through latency in the passive avoidance test. However, there was no significant difference in the oxidative and neuroinflammatory responses among the experimental groups. Conclusion: Pretreatment with crocin attenuates spatial or aversive learning and memory deficits in LPS-treated rats. | ||
کلیدواژهها | ||
Crocin؛ lipopolysaccharide؛ memory؛ interleukin-1β؛ oxidative stress؛ systemic inflammation | ||
مراجع | ||
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