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Ahmadi, Shamseddin, Ghaderi, Halaleh, Saadati, Nazila, Samadi, Saadi. (1399). Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation. , 23(10), 1293-1300. doi: 10.22038/ijbms.2020.44658.10436
Shamseddin Ahmadi; Halaleh Ghaderi; Nazila Saadati; Saadi Samadi. "Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation". , 23, 10, 1399, 1293-1300. doi: 10.22038/ijbms.2020.44658.10436
Ahmadi, Shamseddin, Ghaderi, Halaleh, Saadati, Nazila, Samadi, Saadi. (1399). 'Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation', , 23(10), pp. 1293-1300. doi: 10.22038/ijbms.2020.44658.10436
Ahmadi, Shamseddin, Ghaderi, Halaleh, Saadati, Nazila, Samadi, Saadi. Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation. , 1399; 23(10): 1293-1300. doi: 10.22038/ijbms.2020.44658.10436

Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation

Iranian Journal of Basic Medical Sciences
مقاله 7، دوره 23، شماره 10، دی 2020، صفحه 1293-1300    اصل مقاله (917.41 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.44658.10436
نویسندگان
Shamseddin Ahmadi* 1؛ Halaleh Ghaderi1؛ Nazila Saadati1؛ Saadi Samadi2
1Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Iran
2Department of Chemistry, Faculty of Science, University of Kurdistan, Sanandaj, Iran
چکیده
Objective(s): We aim to examine possible ammonia lowering effects of mesoporous silica SBA-15 in rats after the common bile duct ligation (BDL). We also evaluate the effect of SBA-15 treatments during 28 days of BDL on locomotion and rearing behavior, as well as on the gene expression of Jnk3 and p38alpha (p38α) mitogen-activated protein kinases in the prefrontal cortex (PFC).
Materials and Methods: SBA-15 was prepared with the hydrothermal method from the surfactant P123 and tetraethyl orthosilicate (TEOS), and calcined at 550 ºC. Then, the product was characterized by FT-IR, XRD, SEM, and BJH-BET techniques. Male Wistar rats in sham control and a group with BDL received saline but another group with BDL received SBA-15 during 28 days of BDL. We examined all groups of rats weekly for locomotion and rearing behavior; then on day 28, we sacrificed all rats, collected the blood sample, and finally dissected the PFC from the whole brain.
Results: The SBA-15 treatments had no effect on locomotion but improved rearing behavior on days 7 and 14 of BDL. Biochemical analysis indicated that the SBA-15 treatments in rats with BDL significantly decreased hyperammonemia. The results also revealed that the SBA-15 treatments in rats with BDL significantly restored the decreased Jnk3 gene expression, and increased the p38α gene expression in the PFC.
Conclusion: We conclude that SBA-15 can be used as an ammonia lowering agent in hepatic encephalopathy; however, its improving effects on locomotion and neuroinflammation, as well as signaling molecules in the brain need more investigations.
کلیدواژه‌ها
Ammonia c؛ Jun Kinase 3 Hepatic encephalopathy Inflammations p38 MAPK SBA؛ 15
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