سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Xu, Mingyue, Jiang, Peng, Sun, Haowen, Yuan, Xin, Gao, Siyuan, Guo, Jian, Zhao, Caijun, Hu, Xiaoyu, Liu, Xueshibojie, Fu, Yunhe. (1399). Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice. , 23(9), 1239-1244. doi: 10.22038/ijbms.2020.44151.10346
Mingyue Xu; Peng Jiang; Haowen Sun; Xin Yuan; Siyuan Gao; Jian Guo; Caijun Zhao; Xiaoyu Hu; Xueshibojie Liu; Yunhe Fu. "Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice". , 23, 9, 1399, 1239-1244. doi: 10.22038/ijbms.2020.44151.10346
Xu, Mingyue, Jiang, Peng, Sun, Haowen, Yuan, Xin, Gao, Siyuan, Guo, Jian, Zhao, Caijun, Hu, Xiaoyu, Liu, Xueshibojie, Fu, Yunhe. (1399). 'Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice', , 23(9), pp. 1239-1244. doi: 10.22038/ijbms.2020.44151.10346
Xu, Mingyue, Jiang, Peng, Sun, Haowen, Yuan, Xin, Gao, Siyuan, Guo, Jian, Zhao, Caijun, Hu, Xiaoyu, Liu, Xueshibojie, Fu, Yunhe. Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice. , 1399; 23(9): 1239-1244. doi: 10.22038/ijbms.2020.44151.10346

Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice

Iranian Journal of Basic Medical Sciences
مقاله 17، دوره 23، شماره 9، آذر 2020، صفحه 1239-1244    اصل مقاله (811.78 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.44151.10346
نویسندگان
Mingyue Xu1؛ Peng Jiang1؛ Haowen Sun1؛ Xin Yuan1؛ Siyuan Gao1؛ Jian Guo1؛ Caijun Zhao1؛ Xiaoyu Hu1؛ Xueshibojie Liu* 2؛ Yunhe Fu1
1Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, People, Republic of China
2Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Jilin University, Changchun, China
چکیده
Objective(s): Endometritis is the inflammation of the uterine lining that is associated with infertility. It affects milk production and reproductive performance and leads to huge economic losses in dairy cows. Dimethyl itaconate (DI), a promising chemical agent, has recently been proved to have multiple health-promoting effects. However, the effects of DI on endometritis remain to be unknown.
Materials and Methods: In this study, we assessed the anti-inflammatory effects of DI on Lipopolysaccharide (LPS)-induced endometritis in mice. The endometritis was induced by LPS treatment for 24 hr, and DI was given 24 hr before induction of LPS.
Results: As a result, DI administered mice significantly suffered less impairment of uterine tissue and less recruitment of inflammatory cells than LPS administered mice. In addition, DI markedly inhibited uterine myeloperoxidase (MPO) activity and pro-inflammatory cytokines of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) induced by LPS. Moreover, LPS-induced toll-like receptor 4/ nuclear factor-kappa B (TLR4/NF-κB) activation was suppressed by DI. In addition, the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase (HO-1) were upregulated by DI.
Conclusion: These findings suggest that DI has anti-inflammatory functions in the LPS-induced mice and may be a therapeutic agent against endometritis.
کلیدواژه‌ها
Dimethyl itaconate Endometritis LPS NF؛ κB Nrf2 TLR4
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