Abareshi A, Anaeigoudari A, Norouzi F, Shafei
MN, Boskabady MH, Khazaei M, Hosseini
M. 2016. Lipopolysaccharide-induced
spatial memory and synaptic plasticity
impairment is preventable by captopril. Avd
Med Sci-Poland, 199-214.
Abidin I, Yargicoglu P, Agar A, GÜMÜSLÜ S,
Aydin S, Aydin S, ÖZTÜRK O, Sahin E.
2004. The effect of chronic restraint stress
on spatial learning and memory: relation to
oxidant stress. Int J Neurosci, 114:683-699.
Aebi H. 1984. Catalase in vitro Methods in
enzymology. vol 105. Elsevier, 121-126.
Ameen AM, Elkazaz AY, Mohammad HM,
Barakat BM. 2017. Anti-inflammatory and
neuroprotective activity of boswellic acids
in rotenone parkinsonian rats. CAN J
Physiol Pharma, 95: 819-829.
Anaeigoudari A, Shafei MN, Soukhtanloo M,
Sadeghnia HR, Reisi P, Nosratabadi R,
Behradnia S, Hosseini M. 2015. The effects
of L-arginine on spatial memory and
synaptic plasticity impairments induced by
lipopolysaccharide. Adv Biomed Res, 4-23.
Ashley NT, Weil ZM, Nelson RJ Bansal N,
Mehan S, Kalra S, Khanna D. 2013.
Boswellia serrata-frankincense (A Jesus
Gifted Herb); an updated pharmacological
profile. Pharmacologia, 4: 457-463.
eheshti F, Hosseini M, Hashemzehi M,
Soukhtanloo M, Khazaei M, Shafei MN.
The effects of olibanum and boswellic acid on synaptic plasticity
AJP, Vol. 11, No. 1, Jan-Feb 2021 77
2019. The effects of PPAR-gamma agonist
pioglitazone on hippocampal cytokines,
brain-derived neurotrophic factor, memory
impairment, and oxidative stress status in
lipopolysaccharide-treated rats. Iran J Basic
Med Sci, 22: 940-948.
Beheshti S, Aghaie R. 2016. Therapeutic effect
of frankincense in a rat model of
Alzheimer’s disease. AJP, 6:468-480.
Behl C, Moosmann B. 2002. Antioxidant
neuroprotection in Alzheimer's disease as
preventive and therapeutic approach. Free
Radic Biol Med, 33:182-191.
Camarda L, Dayton T, Di Stefano V, Pitonzo R,
Schillaci D. 2007. Chemical composition
and antimicrobial activity of some oleogum
resin essential oils from Boswellia
spp.(Burseraceae). Annali di Chimica: Env
Cult Heart Chem, 97: 837-844.
Connor JA, Petrozzino J, Pozzo-Miller LD,
Otani S. 1999. Calcium signals in long-term
potentiation and long-term depression. CAN
J Physiol Pharma, 77: 722-734.
Czerniawski J, Miyashita T, Lewandowski G,
Guzowski JF. 2015. Systemic
lipopolysaccharide administration impairs
retrieval of context–object discrimination,
but not spatial, memory: evidence for
selective disruption of specific
hippocampus-dependent memory functions
during acute neuroinflammation. Brain
Behav Immun, 44: 159-166.
Dantzer R, O'Connor JC, Freund GG, Johnson
RW, Kelley KW. 2008. From inflammation
to sickness and depression: when the
immune system subjugates the brain. Nat
Rev Neurosci, 9: 46-56.
Dehmer T, Heneka MT, Sastre M, Dichgans J,
Schulz JB. 2004. Protection by pioglitazone
in the MPTP model of Parkinson's disease
correlates with IκBα induction and block of
NFκB and iNOS activation. J Neurochem,
88: 494-501.
Dubey H, Gulati K, Ray A. 2019. Alzheimer's
disease: A contextual link with nitric oxide
synthase. Curr Mol Med. 2174-21181.
Ebrahimpour S, Fazeli M, Mehri S,
Taherianfard M, Hosseinzadeh H. 2017.
Boswellic acid improves cognitive function
in a rat model through its antioxidant
activity:-neuroprotective effect of boswellic
acid. J Pharmacopunct, 20: 10-22.
Etzel R. 1996. Special extract of Boswellia
serrata (H 15) in the treatment of rheumatoid
arthritis. Pytoemy, 3: 91-94.
Gomaa AA, Makboul RM, Al-Mokhtar MA,
Nicola MA. 2019. Polyphenol-rich
Boswellia serrata gum prevents cognitive
impairment and insulin resistance of
diabetic rats through inhibition of GSK3β
activity, oxidative stress and proinflammatory cytokines. Biomed
Pharmacother, 109: 281-292.
Greenstein YJ, Pavlides C, Winson J. 1988.
Lonf-term potentiation in the dentate gyrus
is preferentially induced at theta rhythm
periodicity. Brain Res, 438: 331-334.
Gupta I, Parihar A, Malhotra P, Gupta S,
Lüdtke R, Safayhi H, Ammon HP. 2001.
Effects of gum resin of Boswellia serrata in
patients with chronic colitis. Planta Medica,
67: 391-395.
Hakimi Z, Salmani H, Marefati N, Arab Z,
Gholamnezhad Z, Beheshti F, Shafei MN,
Hosseini M. 2019. Protective Effects of
Carvacrol on Brain Tissue Inflammation and
Oxidative Stress as well as Learning and
Memory in Lipopolysaccharide-Challenged
Rats. Neurotox Res, 1-12.
Hosseini-sharifabad M, Esfandiari E. 2015.
Effect of Boswellia serrata gum resin on the
morphology of hippocampal CA1 pyramidal
cells in aged rat. Anat Sci Int, 90: 47-53.
Hosseini M, Hadjzadeh MAR, Derakhshan M,
Havakhah S, Rassouli FB, Rakhshandeh H,
Saffarzadeh F. 2010. The beneficial effects
of olibanum on memory deficit induced by
hypothyroidism in adult rats tested in Morris
water maze. Arch Pharm Res, 33: 463-468.
Hritcu L, Ciobica A, Stefan M, Mihasan M,
Palamiuc L, Nabeshima T. 2011. Spatial
memory deficits and oxidative stress
damage following exposure to
lipopolysaccharide in a rodent model of
Parkinson's disease. J Neurosci Res, 71: 35-
43.
Ivanova VO, Balaban PM, Bal NV. 2020.
Modulation of AMPA Receptors by Nitric
Oxide in Nerve Cells. Int J Mol Sci, 21: 981-
993.
Jalili C, Salahshoor M, Pourmotabbed A,
Moradi S, Roshankhah S, Darehdori A S,
Motaghi M. 2014. The effects of aqueous
extract of Boswellia Serrata on hippocampal
region CA1 and learning deficit in kindled
rats. Res Pharm Sci, 9:351-365.
Jivad N, Rafieian-Kopaei M, RezaeiKheirabadi F, Khosravi S, Azizi M. 2015. A
study of the clinical efficacy of frankincense
in the acute phase of ischemic stroke. Adv
Herb Med, 1:4-10.
Jo J-H, Park E-J, Lee J-K, Jung M-W, Lee C-J.
Marefati et al.
AJP, Vol. 11, No. 1, Jan-Feb 2021 78
2001. Lipopolysaccharide inhibits induction
of long-term potentiation and depression in
the rat hippocampal CA1 area. Eur J
Pharmacol, 422: 69-76.
Kacem M, Simon G, Leschiera R, Misery L,
ElFeki A, Lebonvallet N. 2015. Antioxidant
and anti-inflammatory effects of Ruta
chalepensis L. extracts on LPS-stimulated
RAW 264.7 cells. In Vitro Cell Dev Biol
Anim, 51: 128-141.
Kheir-Eldin AA, Motawi TK, Gad MZ, AbdElGawad HM. 2001. Protective effect of
vitamin E, β-carotene and N-acetylcysteine
from the brain oxidative stress induced in
rats by lipopolysaccharide. Int J Biochem,
33: 475-482.
Kimmatkar N, Thawani V, Hingorani L,
Khiyani R. 2003. Efficacy and tolerability of
Boswellia serrata extract in treatment of
osteoarthritis of knee–a randomized double
blind placebo controlled trial.
Phytomedicine, 10: 3-7.
Koppenhöfer D, Kettenbaum F, Susloparova A,
Law J, Vu X, Schwab T, Schäfer K,
Ingebrandt S. 2015. Neurodegeneration
through oxidative stress: Monitoring
hydrogen peroxide induced apoptosis in
primary cells from the subventricular zone
of BALB/c mice using field-effect
transistors. Biosens Bioelectron, 67: 490-
496.
Kumar S, Prasad A, Iyer VS, Sahu A. 2012.
Systemic review: Pharmacognosy,
Phytochemistry and Pharmacology of
Martynia annua. Int J Res Med, 1: 34-39.
Madesh M, Balasubramanian K. 1998.
Microtiter plate assay for superoxide
dismutase using MTT reduction by
superoxide. Indian J Clin Biochem, 35: 184-
188.
Marefati N, Beheshti F, Memarpour S, Bayat R,
Shafei MN, Sadeghnia HR, Ghazavi H,
Hosseini M. 2020. The effects of acetyl-11-
keto-β-boswellic acid on brain cytokines
and memory impairment induced by
lipopolysaccharide in rats. Cytokine,
31:155-164.
Marottoli FM, Katsumata Y, Koster KP,
Thomas R, Fardo DW, Tai LM. 2017.
Peripheral Inflammation, Apolipoprotein
E4, and Amyloid-beta Interact to Induce
Cognitive and Cerebrovascular
Dysfunction. ASN Neuro, 9:
1759091417719201.
Moussaieff A, Mechoulam R. 2009. Boswellia
resin: from religious ceremonies to medical
uses; a review of in‐vitro, in‐vivo and
clinical trials. J Pharm Pharmacol, 61: 1281-
1293.
Podda M V, Cocco S, Mastrodonato A, Fusco
S, Leone L, Barbati S A, Colussi C, Ripoli
C, Grassi C. 2016. Anodal transcranial
direct current stimulation boosts synaptic
plasticity and memory in mice via
epigenetic regulation of BDNF expression.
Sci Rep, 6: 180-187.
Quan N, Sundar SK, Weiss JM. 1994. Induction
of interleukin-1 in various brain regions
after peripheral and central injections of
lipopolysaccharide. J Neuroimmunol, 49:
125-134.
Qurishi Y, Hamid A, Zargar M, Singh SK,
Saxena AK. 2010. Potential role of natural
molecules in health and disease: Importance
of boswellic acid. J Med Plants Res, 4: 2778-
2785.
Saavedra JM. 2012. Angiotensin II AT1
receptor blockers as treatments for
inflammatory brain disorders. Clin Sci, 123:
567-590.
Sayed A, El Sayed N. 2016. Co-administration
of 3-acetyl-11-keto-beta-boswellic acid
potentiates the protective effect of celecoxib
in lipopolysaccharide-induced cognitive
impairment in mice: possible implication of
anti-inflammatory and antiglutamatergic
pathways. J Mol Neurosci, 59: 58-67.
Upaganlawar A, Ghule B. 2009.
Pharmacological activities of Boswellia
serrata Roxb.-mini review. Ethnobot
Leaflets., 2009: 10-18.
Weber C-C, Reising K, Müller WE, SchubertZsilavecz M, Abdel-Tawab M. 2006.
Modulation of Pgp function by boswellic
acids. Planta medica, 72: 507-513.
Zaker S, Beheshti S, Aghaie R, Noorbakhshnia
M, 2015. Effect of olibanum on a rat model
of Alzheimer’s disease induced by
intracerebroventricular injection of
streptozotocin. J Physiol Pharmacol,
18:477-489.
Zheng WH, Quirion R. 2004. Comparative
signaling pathways of insulin‐like growth
factor‐1 and brain‐derived neurotrophic
factor in hippocampal neurons and the role
of the PI3 kinase pathway