Do Antibiotic Beads Need to be Removed? | ||
The Archives of Bone and Joint Surgery | ||
مقاله 4، دوره 8، شماره 4، مهر 2020، صفحه 502-505 اصل مقاله (385.31 K) | ||
نوع مقاله: RESEARCH PAPER | ||
شناسه دیجیتال (DOI): 10.22038/abjs.2020.44143.2208 | ||
نویسندگان | ||
Navin Fernando1؛ Shawn Werner2؛ Moamen Elhaddad3؛ Jonah Davies3؛ Reza Firoozabadi* 3 | ||
1Hip and Knee Center at Northwest Primary and Specialty Care North Seattle, University of Washington, Seattle, WA, USA | ||
2Aurora Medical Center Summit Oconomowoc, WI, USA | ||
3Department of Orthopedic Surgery, Harborview Medical Center, University of Washington, Seattle, WA, USA | ||
چکیده | ||
Background: Polymethylmethacrylate antibiotic impregnated beads can be an effective treatment for chronic osteomyelitis or an adjuvant in the treatment of open fractures. It remains unclear however whether the beads cause long-term adverse events if not removed. The purpose of this study was to determine if removal of antibiotic beads was required in order to avoid long term complications. Methods: A retrospective chart review was conducted on patients with an extremity or pelvis fracture that had implantation of polymethylmethacrylate (PMMA) antibiotic beads over a five-year period. Results: Fifty-one patients met inclusion criteria for this study; thirty-seven patients (73%) did not have complications after surgical debridement and placement of PMMA antibiotic beads necessitating removal. Conclusion: Our findings suggest that polymethylmethacrylate antibiotic beads can be utilized as a means of delivering high-dose concentrations of local antibiotics and do not have to be removed in all patients. Level of evidence: III | ||
کلیدواژهها | ||
Antibiotics؛ Antibiotic beads؛ Antibiotic resistance؛ Fracture؛ Infection | ||
مراجع | ||
1. Cook GE, Markel DC, Ren W, Webb LX, McKee MD, Schemitsch EH. Infection in Orthopaedics. J Orthop Trauma. 2015;29 Suppl 12:S19-23. PubMed PMID: 26584261. Epub 2015/11/20. eng. 2. Morgenstern M, Kuhl R, Eckardt H, Acklin Y, Stanic B, Garcia M, et al. Diagnostic challenges and future perspectives in fracture-related infection. Injury. 2018;49 Suppl 1:S83-s90. PubMed PMID: 29929701. Epub 2018/06/23. eng. 3. Kamath AF, Ong KL, Lau E, Chan V, Vail TP, Rubash HE, et al. Quantifying the Burden of Revision Total Joint Arthroplasty for Periprosthetic Infection. J Arthroplasty. 2015;30(9):1492-7. PubMed PMID: 25865815. Epub 2015/04/14. eng. 4. Pull ter Gunne AF, Cohen DB. Incidence, prevalence, and analysis of risk factors for surgical site infection following adult spinal surgery. Spine (Phila Pa 1976). 2009;34(13):1422-8. PubMed PMID: 19478664. Epub 2009/05/30. eng. 5. Zalavras CG. Prevention of Infection in Open Fractures. Infect Dis Clin North Am. 2017;31(2):339-52. PubMed PMID: 28292542. Epub 2017/03/16. eng. 6. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976;58(4):453-8. PubMed PMID: 773941. Epub 1976/06/01. eng. 7. Bhandari M, Guyatt G, Tornetta P, 3rd, Schemitsch EH, Swiontkowski M, Sanders D, et al. Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am. 2008;90(12):2567-78. PubMed PMID: 19047701. Pubmed Central PMCID: PMC2663330. Epub 2008/12/03. eng. 8. Wahlig H, Dingeldein E, Bergmann R, Reuss K. The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study. J Bone Joint Surg Br. 1978;60-b(2):270-5. PubMed PMID: 659478. Epub 1978/05/01. eng. 9. Klemm K. [Gentamicin-PMMA-beads in treating bone and soft tissue infections (author’s transl)]. Zentralbl Chir. 1979;104(14):934-42. PubMed PMID: 494865. Epub 1979/01/01. Gentamycin-PMMA-Kugeln in der Behandlung abszedierender Knochen- und Weichteilinfektionen. ger. 10. Henry SL, Hood GA, Seligson D. Long-term implantation of gentamicin-polymethylmethacrylate antibiotic beads. Clin Orthop Relat Res. 1993 (295):47-53. PubMed PMID: 8403670. Epub 1993/10/01. eng. 11. Neut D, van de Belt H, van Horn JR, van der Mei HC, Busscher HJ. Residual gentamicin-release from antibiotic-loaded polymethylmethacrylate beads after 5 years of implantation. Biomaterials. 2003; 24(10):1829-31. PubMed PMID: 12593965. Epub 2003/02/21. eng. 12. Nelson CL. The current status of material used for depot delivery of drugs. Clin Orthop Relat Res. 2004 (427):72-8. PubMed PMID: 15552140. Epub 2004/11/24. eng. 13. Wininger DA, Fass RJ. Antibiotic-impregnated cement and beads for orthopedic infections. Antimicrob Agents Chemother. 1996;40(12):2675-9. PubMed PMID: 9124821. Pubmed Central PMCID: PMC163602. Epub 1996/12/01. eng. 14. Ostermann PA, Seligson D, Henry SL. Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases. J Bone Joint Surg Br. 1995;77(1):93- 7. PubMed PMID: 7822405. Epub 1995/01/01. eng. 15. Calhoun JH, Henry SL, Anger DM, Cobos JA, Mader JT. The treatment of infected nonunions with gentamicinpolymethylmethacrylate antibiotic beads. Clin Orthop Relat Res. 1993 (295):23-7. PubMed PMID: 8403654. Epub 1993/10/01. eng. 16. Borrelli J, Jr., Prickett WD, Ricci WM. Treatment of nonunions and osseous defects with bone graft and calcium sulfate. Clin Orthop Relat Res. 2003 (411):245-54. PubMed PMID: 12782881. Epub 2003/06/05. eng. 17. McKee MD, Li-Bland EA, Wild LM, Schemitsch EH. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma. 2010;24(8):483-90. PubMed PMID: 20657257. Epub 2010/07/27. eng. | ||
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