The Relationship between the Level of Pregnancy-Associated Plasma Protein A and Placenta Size and Thickness | ||
| International Journal of Pediatrics | ||
| مقاله 10، دوره 9، شماره 4 - شماره پیاپی 88، تیر 2021، صفحه 13381-13388 اصل مقاله (491.55 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijp.2020.49676.3971 | ||
| نویسندگان | ||
| Sima Fallah Arzpeyma1؛ Zohre Asadi2؛ Sodaboeh Kazemi* 3؛ Ehsan Kazemnejad-Leili4 | ||
| 1Assistant Professor of Radiology, Department of Radiology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. | ||
| 2Resident of Radiology, Reproductive Health Research Center, Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran. | ||
| 3Assistant Professor of Obstetrics and Gynecology, Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-Zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. | ||
| 4Associate Professor, Department of Biostatistics, Social Determinants of Health Research Center, Guilan University of Medical Sciences, Rasht, Iran. | ||
| چکیده | ||
| Background: The low level of pregnancy-associated plasma protein A (PAPP-A) has a relationship with unfavorable outcomes in neonates. This study aimed to evaluate the association between the thickness and size of the placenta in singleton pregnant women. Materials and Methods: In this prospective cohort study, 102 women were investigated in 18-23 weeks and PAPP-A level at the gestational age in 11-14 weeks with a singleton pregnancy who referred to Al-Zahra Hospital, Rasht, Iran, between 2017 and 2018. Serum PAPP-A of pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A ≤ 0.5 Multiple of the Median (MOM (were dedicated to an exposed group and others to a non-exposed group. Placental thickness and size were assessed during the second trimester by ultrasound examination and described as abnormal high thickness if the thickness was > 4 cm or more than 50% of the placental length and abnormally small size when the maximum length was < 10 cm. Then, placental thickness and size were compared between the two groups. Results: PAPP-A levels of > 0.5 and ≤ 0.5 were recorded in 60 and 34 patients, respectively. Women with low levels of PAPP-A in the first trimester had an increased incidence of abnormal placental thickness in 13 cases and small placental size in 7 cases, whereas this number was 12 and 7 cases, respectively, in the other group (P = 0.023). The sensitivity and specificity of PAPP-A < 0.55 were 72.3 and 56% for abnormal placental thickness, respectively; the sensitivity and specificity of PAPP-A < 0.55 were 69.3 and 57.1%, respectively, in the assessment of abnormal placenta size. Conclusion Based on the results, the size and thicknesses of the placenta were abnormal in women with a low level of PAPP-A (≤ 0.5). | ||
| کلیدواژهها | ||
| PAPP-A؛ Pregnancy؛ Placenta؛ Women | ||
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