allogeneic blood during orthopedic surgery. Mt Sinai
J Med. 2002; 69(1-2):83-7.
11. Lemaire R. Strategies for blood management in
orthopaedic and trauma surgery. J Bone Joint Surg
Br. 2008; 90(9):1128-36.
12. Eubanks JD. Antifibrinolytics in major orthopaedic
surgery. J Am Acad Orthop Surg. 2010; 18(3):132-8.
13. Camarasa M, Ollé G, Serra-Prat M, Martí􀆴n A, Sánchez
M, Ricós P, et al. Efficacy of aminocaproic, tranexamic
acids in the control of bleeding during total knee
replacement: a randomized clinical trial. Br J
Anaesth. 2006; 96(5):576-82.
14. Molloy DO, Archbold HA, Ogonda L, McConway J,
Wilson RK, Beverland DE. Comparison of topical
fibrin spray and tranexamic acid on blood loss after
total knee replacement: a prospective, randomised
controlled trial. J Bone Joint Surg Br. 2007;
89(3):306-9.
15. Vigna-Taglianti F, Basso L, Rolfo P, Brambilla R,
Vaccari F, Lanci G, et al. Tranexamic acid for reducing
blood transfusions in arthroplasty interventions: a
cost-effective practice. Eur J Orthop Surg Traumatol.
2014; 24(4):545-51.
16. Badeaux J, Hawley D. A systematic review of the
effectiveness of intravenous tranexamic acid
administration in managing perioperative blood loss
in patients undergoing spine surgery. J Perianesth
Nurs. 2014; 29(6):459-65.
17. Melvin JS, Stryker LS, Sierra RJ. Tranexamic acid in
hip and knee arthroplasty. J Am Acad Orthop Surg.
2015; 23(12):732-40.
18. MacGillivray RG, Tarabichi SB, Hawari MF, Raoof NT.
Tranexamic acid to reduce blood loss after bilateral
total knee arthroplasty: a prospective, randomized
double blind study. J Arthroplasty. 2011; 26(1):24-8.
19. Chen JY, Chin PL, Moo IH, Pang HN, Tay DKJ, Chia SL,
et al. Intravenous versus intra-articular tranexamic
acid in total knee arthroplasty: a double-blinded
randomised controlled noninferiority trial. Knee.
1. Lin ZX, Woolf SK. Safety, efficacy, and costeffectiveness
of tranexamic acid in orthopedic
surgery. Orthopedics. 2016; 39(2):119-30.
2. Kagoma YK, Crowther MA, Douketis J, Bhandari M,
Eikelboom J, Lim W. Use of antifibrinolytic therapy to
reduce transfusion in patients undergoing orthopedic
surgery: a systematic review of randomized trials.
Thromb Res. 2009; 123(5):687-96.
3. Wind TC, Barfield WR, Moskal JT. The effect of
tranexamic acid on blood loss and transfusion rate
in primary total knee arthroplasty. J Arthroplasty.
2013; 28(7):1080-3.
4. Quintero JI, Cárdenas LL, Navas M, Bautista
MP, Bonilla GA, Llinás AM, et al. Primary joint
arthroplasty surgery: is the risk of major bleeding
higher in elderly patients? A retrospective cohort
study. J Arthroplasty. 2016; 31(10):2264-8.
5. Bong MR, Patel V, Chang E, Issack PS, Hebert R, Di
Cesare PE. Risks associated with blood transfusion
after total knee arthroplasty. J Arthroplasty. 2004;
19(3):281-7.
6. Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J.
Periprosthetic joint infection: the incidence, timing,
and predisposing factors. Clin Orthop Relat Res.
2008; 466(7):1710-5.
7. Sarzaeem MM, Razi M, Kazemian G, Moghaddam
ME, Rasi AM, Karimi M. Comparing efficacy of
three methods of tranexamic acid administration
in reducing hemoglobin drop following total knee
arthroplasty. J Arthroplasty. 2014; 29(8):1521-4.
8. Rasouli MR, Gomes LS, Parsley B, Barsoum W,
Bezwada H, Cashman J, et al. Blood conservation. J
Arthroplasty. 2014; 29(2 Suppl):65-70.
9. Keyhani S, Esmailiejah AA, Abbasian MR, Safdari
F. Which route of tranexamic acid administration
is more effective to reduce blood loss following
total knee arthroplasty? Arch Bone Jt Surg. 2016;
4(1):65-9.
10. Rosenblatt MA. Strategies for minimizing the use of 

allogeneic blood during orthopedic surgery. Mt Sinai
J Med. 2002; 69(1-2):83-7.
11. Lemaire R. Strategies for blood management in
orthopaedic and trauma surgery. J Bone Joint Surg
Br. 2008; 90(9):1128-36.
12. Eubanks JD. Antifibrinolytics in major orthopaedic
surgery. J Am Acad Orthop Surg. 2010; 18(3):132-8.
13. Camarasa M, Ollé G, Serra-Prat M, Martí􀆴n A, Sánchez
M, Ricós P, et al. Efficacy of aminocaproic, tranexamic
acids in the control of bleeding during total knee
replacement: a randomized clinical trial. Br J
Anaesth. 2006; 96(5):576-82.
14. Molloy DO, Archbold HA, Ogonda L, McConway J,
Wilson RK, Beverland DE. Comparison of topical
fibrin spray and tranexamic acid on blood loss after
total knee replacement: a prospective, randomised
controlled trial. J Bone Joint Surg Br. 2007;
89(3):306-9.
15. Vigna-Taglianti F, Basso L, Rolfo P, Brambilla R,
Vaccari F, Lanci G, et al. Tranexamic acid for reducing
blood transfusions in arthroplasty interventions: a
cost-effective practice. Eur J Orthop Surg Traumatol.
2014; 24(4):545-51.
16. Badeaux J, Hawley D. A systematic review of the
effectiveness of intravenous tranexamic acid
administration in managing perioperative blood loss
in patients undergoing spine surgery. J Perianesth
Nurs. 2014; 29(6):459-65.
17. Melvin JS, Stryker LS, Sierra RJ. Tranexamic acid in
hip and knee arthroplasty. J Am Acad Orthop Surg.
2015; 23(12):732-40.
18. MacGillivray RG, Tarabichi SB, Hawari MF, Raoof NT.
Tranexamic acid to reduce blood loss after bilateral
total knee arthroplasty: a prospective, randomized
double blind study. J Arthroplasty. 2011; 26(1):24-8.
19. Chen JY, Chin PL, Moo IH, Pang HN, Tay DKJ, Chia SL,
et al. Intravenous versus intra-articular tranexamic
acid in total knee arthroplasty: a double-blinded
randomised controlled noninferiority trial. Knee.

2016; 23(1):152-6.
20. Gomez-Barrena E, Ortega-Andreu M, Padilla-Eguiluz
NG, Pérez-Chrzanowska H, Figueredo-Zalve R.
Topical intra-articular compared with intravenous
tranexamic acid to reduce blood loss in primary
total knee replacement: a double-blind, randomized,
controlled, noninferiority clinical trial. J Bone Joint
Surg Am. 2014; 96(23):1937-44.
21. Seo JG, Moon YW, Park SH, Kim SM, Ko KR. The
comparative efficacies of intra-articular and IV
tranexamic acid for reducing blood loss during total
knee arthroplasty. Knee Surg Sports Traumatol
Arthrosc. 2013; 21(8):1869-74.
22. Goyal N, Chen DB, Harris IA, Rowden NJ, Kirsh
G, MacDessi SJ. Intravenous vs intra-articular
tranexamic acid in total knee arthroplasty: a
randomized, double-blind trial. J Arthroplasty. 2017;
32(1):28-32.
23. Lee SY, Chong S, Balasubramanian D, Na YG, Kim
TK. What is the ideal route of administration of
tranexamic acid in TKA? A randomized controlled
trial. Clin Orthop Relat Res. 2017; 475(8):1987-96.
24. Mi B, Liu G, Zhou W, Lv H, Liu Y, Zha K, et al. Intraarticular
versus intravenous tranexamic acid
application in total knee arthroplasty: a metaanalysis
of randomized controlled trials. Arch Orthop
Trauma Surg. 2017; 137(7):997-1009.
25. Soni A, Saini R, Gulati A, Paul R, Bhatty S, Rajoli SR.
Comparison between intravenous and intra-articular
regimens of tranexamic acid in reducing blood loss
during total knee arthroplasty. J Arthroplasty. 2014;
29(8):1525-7.
26. Myers SP, Kutcher ME, Rosengart MR, Sperry JL,
Peitzman AB, Brown JB, et al. Tranexamic acid
administration is associated with an increased
risk of post-traumatic venous thromboembolism. J
Trauma Acute Care Surg. 2019; 86(1):20-7.
27. Å􀇒 stedt B. Clinical pharmacology of tranexamic acid.
Scand J Gastroenterol. 1987; 22(137):22-5.
28. Heller S, Secrist E, Shahi A, Chen AF, Parvizi
J. Tranexamic acid can be administered to
arthroplasty patients who receive aspirin for venous
thromboembolic prophylaxis. J Arthroplasty. 2016;
31(7):1437-41.
29. Good L, Peterson E, Lisander B. Tranexamic acid
decreases external blood loss but not hidden blood
loss in total knee replacement. Br J Anaesth. 2003;
90(5):596-9.
30. Nadler SB, Hidalgo JU, Bloch T. Prediction of blood
volume in normal human adults. Surgery. 1962;
51(2):224-32.
31. Kirksey M, Chiu YL, Ma Y, Della Valle AG,
Poultsides L, Gerner P, et al. Trends in in-hospital
major morbidity and mortality after total joint
arthroplasty: United States 1998-2008. Anesth
Analg. 2012; 115(2):321-7.
32. Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR.
Most effective regimen of tranexamic acid in knee
arthroplasty: a prospective randomized controlled
study in 240 patients. Clin Orthop Relat Res. 2012;
470(9):2605-12.

33. Patel JN, Spanyer JM, Smith LS, Huang J, Yakkanti
MR, Malkani AL. Comparison of intravenous versus
topical tranexamic acid in total knee arthroplasty: a
prospective randomized study. J Arthroplasty. 2014;
29(8):1528-31.
34. Alshryda S, Sarda P, Sukeik M, Nargol A, Blenkinsopp
J, Mason JM. Tranexamic acid in total knee
replacement: a systematic review and meta-analysis.
J Bone Joint Surg Br. 2011; 93(12):1577-85.
35. Nawabi DH. Topical tranexamic acid was noninferior
to intravenous tranexamic Acid in controlling blood
loss during total knee arthroplasty. J Bone Joint Surg
Am. 2015; 97(4):343.
36. Ueno M, Sonohata M, Fukumori N, Kawano S, Kitajima
M, Mawatari M. Comparison between topical and
intravenous administration of tranexamic acid in
primary total hip arthroplasty. J Orthop Sci. 2016;
21(1):44-7.
37. Uğurlu M, Aksekili MA, Çağlar C, Yüksel K, Şahin
E, Akyol M. Effect of topical and intravenously
applied tranexamic acid compared to control
group on bleeding in primary unilateral total knee
arthroplasty. J Knee Surg. 2017; 30(02):152-7.
38. Aggarwal AK, Singh N, Sudesh P. Topical vs
intravenous tranexamic acid in reducing blood loss
after bilateral total knee arthroplasty: a prospective
study. J Arthroplasty. 2016; 31(7):1442-8.
39. Aguilera X, Martí􀆴nez-Zapata MJ, Hinarejos P, Jordan
M, Leal J, Gonzalez J, et al. Topical and intravenous
tranexamic acid reduce blood loss compared to
routine hemostasis in total knee arthroplasty: a
multicenter, randomized, controlled trial. Arch
Orthop Trauma Surg. 2015; 135(7):1017-25.
40. Digas G, Koutsogiannis I, Meletiadis G, Antonopoulou
E, Karamoulas V, Bikos C. Intra-articular injection of
tranexamic acid reduce blood loss in cemented total
knee arthroplasty. Eur J Orthop Surg Traumatol.
2015; 25(7):1181-8.
41. Hamlin BR, DiGioia AM, Plakseychuk AY, Levison TJ.
Topical versus intravenous tranexamic acid in total
knee arthroplasty. J Arthroplasty. 2015; 30(3):384-6.
42. Ishida K, Tsumura N, Kitagawa A, Hamamura S,
Fukuda K, Dogaki Y, et al. Intra-articular injection of
tranexamic acid reduces not only blood loss but also
knee joint swelling after total knee arthroplasty. Int
Orthop. 2011; 35(11):1639-45.
43. Shemshaki H, Nourian SM, Nourian N, Dehghani M,
Mokhtari M, Mazoochian F. One step closer to sparing
total blood loss and transfusion rate in total knee
arthroplasty: a meta-analysis of different methods
of tranexamic acid administration. Arch Orthop
Trauma Surg. 2015; 135(4):573-88.
44. Wong J, Abrishami A, El Beheiry H, Mahomed NN,
Davey JR, Gandhi R, et al. Topical application of
tranexamic acid reduces postoperative blood loss
in total knee arthroplasty: a randomized, controlled
trial. J Bone Joint Surg Am. 2010; 92(15):2503-13.
45. Yang Y, Lv YM, Ding PJ, Li J, Ying-Ze Z. The reduction in
blood loss with intra-articular injection of tranexamic
acid in unilateral total knee arthroplasty without
operative drains: a randomized controlled trial. Eur J 

Orthop Surg Traumatol. 2015; 25(1):135-9.
46. Geerts WH, Bergqvist D, Pineo GF, Heit JA,
Samama CM, Lassen MR, et al. Prevention of
venous thromboembolism: American College
of Chest Physicians evidence-based clinical
practice guidelines (8th Edition). Chest. 2008;
133(6):381S-453S.