سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mosapour, Abbas, Karami Tehrani, Fatemeh Soghra, Atri, Morteza. (1399). Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors. , 23(8), 1045-1052. doi: 10.22038/ijbms.2020.44581.10421
Abbas Mosapour; Fatemeh Soghra Karami Tehrani; Morteza Atri. "Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors". , 23, 8, 1399, 1045-1052. doi: 10.22038/ijbms.2020.44581.10421
Mosapour, Abbas, Karami Tehrani, Fatemeh Soghra, Atri, Morteza. (1399). 'Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors', , 23(8), pp. 1045-1052. doi: 10.22038/ijbms.2020.44581.10421
Mosapour, Abbas, Karami Tehrani, Fatemeh Soghra, Atri, Morteza. Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors. , 1399; 23(8): 1045-1052. doi: 10.22038/ijbms.2020.44581.10421

Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors

Iranian Journal of Basic Medical Sciences
مقاله 11، دوره 23، شماره 8، آبان 2020، صفحه 1045-1052    اصل مقاله (595.84 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.44581.10421
نویسندگان
Abbas Mosapour1؛ Fatemeh Soghra Karami Tehrani* 1؛ Morteza Atri2
1Cancer Research Lab, Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2Department of Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): MicroRNAs (miRs) are a class of small non-coding RNAs which are associated with tumor growth and progression. In the present study, we assessed the expression of selected miRs in malignant, benign, and adjacent normal breast tissues.
Materials and Methods: The expression of miR-1297, miR-3191-5P, miR-4435, and miR-4465 were evaluated in malignant (n=50), benign (n=35), and adjacent normal breast tissues (n=20) using qRT-PCR. Receiver operating characteristic curves and the area under the ROC curve and AUC were generated for evaluating the diagnostic values of miRs. To evaluate diagnostic efficacy, miRs-based score was obtained using the logistic regression model.
Results: Among malignant tumors, the expression of miR-1297, miR-3191-5p, and miR-4435 was significantly lower (P=0.024, PConclusion: The panel of these miRs are suggested as possible onco-miRs(miR-4465) or tumor suppressor-miRs (miR-3191-5P, miR-1297, miR-4435). Overall, our results indicated that these miRs could be introduced as diagnostic biomarkers in breast cancer patients.
کلیدواژه‌ها
Biomarker؛ Breast cancer؛ Diagnosis؛ miR (MicroRNA)؛ oncomiR
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