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Fardid, Reza, Fazilatpour, Hossein, Ebrahimi, Narges, Sadeghi, Ali, Zare, Tahereh. (1399). Evaluation of the Effects of Curcumin and Lycopene Treatment on Human Lymphocytes before 2 and 6 Gy of 6 MV X-Ray Irradiation. , 18(2), 117-122. doi: 10.22038/ijmp.2020.44248.1676
Reza Fardid; Hossein Fazilatpour; Narges Ebrahimi; Ali Sadeghi; Tahereh Zare. "Evaluation of the Effects of Curcumin and Lycopene Treatment on Human Lymphocytes before 2 and 6 Gy of 6 MV X-Ray Irradiation". , 18, 2, 1399, 117-122. doi: 10.22038/ijmp.2020.44248.1676
Fardid, Reza, Fazilatpour, Hossein, Ebrahimi, Narges, Sadeghi, Ali, Zare, Tahereh. (1399). 'Evaluation of the Effects of Curcumin and Lycopene Treatment on Human Lymphocytes before 2 and 6 Gy of 6 MV X-Ray Irradiation', , 18(2), pp. 117-122. doi: 10.22038/ijmp.2020.44248.1676
Fardid, Reza, Fazilatpour, Hossein, Ebrahimi, Narges, Sadeghi, Ali, Zare, Tahereh. Evaluation of the Effects of Curcumin and Lycopene Treatment on Human Lymphocytes before 2 and 6 Gy of 6 MV X-Ray Irradiation. , 1399; 18(2): 117-122. doi: 10.22038/ijmp.2020.44248.1676

Evaluation of the Effects of Curcumin and Lycopene Treatment on Human Lymphocytes before 2 and 6 Gy of 6 MV X-Ray Irradiation

Iranian Journal of Medical Physics
مقاله 6، دوره 18، شماره 2، خرداد و تیر 2021، صفحه 117-122    اصل مقاله (997.76 K)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2020.44248.1676
نویسندگان
Reza Fardid1؛ Hossein Fazilatpour2؛ Narges Ebrahimi2؛ Ali Sadeghi2؛ Tahereh Zare* 3
1Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Introduction: Today, the use of ionizing radiation in medicine has grown as an important tool for diagnosis and treatment of diseases. However, the harmful effects of radiation should be also considered. Some substances such as lycopene and curcumin can reduce or increase the harmful effects of radiation on humans. So the aim of this study was to evaluate the radioprotective effects of lycopene and curcumin based on the MN assay.
Material and Methods: In this study, the effects of lycopene and curcumin on reducing or increasing the harmful effects of radiation were studied using the micronucleus assay. The effects of lycopene (5 μg/mL) and curcumin (5 μg/mL) were evaluated at radiation doses of 2 and 6 Gy.
Results: The results indicated that the simultaneous use of curcumin and lycopene can be radioprotective at low radiation doses (2 Gy; p <0.001) and radiosensitizing at high doses (6 Gy; P>0.05).
Conclusion: Based on the present results, further research using other methods may contribute to our understanding of the effect of simultaneous use of curcumin and lycopene at low and high doses of X-ray radiation.
کلیدواژه‌ها
Lycopene؛ Curcumin؛ Radiation؛ Micronucleus Assay
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