سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Farjami, Mahsa, Asadi, Reza, Afzal Javan, Fahimeh, Alimardani, Malihe, Eslami, Saeed, Mansoori Derakhshan, Sima, Eslahi, Atieh, Mojarad, Majid. (1399). The worldwide frequency of MYO15A gene mutations in patients with autosomal recessive non-syndromic hearing loss: A meta‐analysis. , 23(7), 841-848. doi: 10.22038/ijbms.2020.35977.8563
Mahsa Farjami; Reza Asadi; Fahimeh Afzal Javan; Malihe Alimardani; Saeed Eslami; Sima Mansoori Derakhshan; Atieh Eslahi; Majid Mojarad. "The worldwide frequency of MYO15A gene mutations in patients with autosomal recessive non-syndromic hearing loss: A meta‐analysis". , 23, 7, 1399, 841-848. doi: 10.22038/ijbms.2020.35977.8563
Farjami, Mahsa, Asadi, Reza, Afzal Javan, Fahimeh, Alimardani, Malihe, Eslami, Saeed, Mansoori Derakhshan, Sima, Eslahi, Atieh, Mojarad, Majid. (1399). 'The worldwide frequency of MYO15A gene mutations in patients with autosomal recessive non-syndromic hearing loss: A meta‐analysis', , 23(7), pp. 841-848. doi: 10.22038/ijbms.2020.35977.8563
Farjami, Mahsa, Asadi, Reza, Afzal Javan, Fahimeh, Alimardani, Malihe, Eslami, Saeed, Mansoori Derakhshan, Sima, Eslahi, Atieh, Mojarad, Majid. The worldwide frequency of MYO15A gene mutations in patients with autosomal recessive non-syndromic hearing loss: A meta‐analysis. , 1399; 23(7): 841-848. doi: 10.22038/ijbms.2020.35977.8563

The worldwide frequency of MYO15A gene mutations in patients with autosomal recessive non-syndromic hearing loss: A meta‐analysis

Iranian Journal of Basic Medical Sciences
مقاله 1، دوره 23، شماره 7، مهر 2020، صفحه 841-848    اصل مقاله (1.02 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.35977.8563
نویسندگان
Mahsa Farjami1، 2؛ Reza Asadi3؛ Fahimeh Afzal Javan2، 4؛ Malihe Alimardani1، 2؛ Saeed Eslami5، 6؛ Sima Mansoori Derakhshan7، 8، 9؛ Atieh Eslahi1، 2؛ Majid Mojarad* 1، 10
1Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Education Development Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
6Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7Department of Medical Genetics, Tabriz University of Medical Sciences, Tabriz, Iran
8Ibn Sina Medical Genetic Diagnostic Laboratory, Tabriz University of Medical Sciences, Tabriz, Iran
9Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
10Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
MYO15A is the third most crucial gene in hereditary sensorineural hearing loss after GJB2 and SLC26A4. In the present study, we reviewed the prevalence of MYO15A mutations in patients with autosomal recessive non-syndromic hearing loss (ARNSHL). In this meta-analysis, we conducted a search of PubMed, Web of Science, Excerpta Medica Database, and Scopus, and identified the articles up to September 2019 without any time limit. Two investigators independently selected the relevant papers and extracted the required information. A total of 44 case-control and case series studies were considered, and 4176 patients and 3706 healthy individuals, as the control group, were included. The pooled frequency of MYO15A mutations between patients suffering from ARNSHL was calculated as 6.2% (95% CI: 4.9-7.8, P-value<0.001). There was heterogeneity between our studies (P-value<0.001, I2=58.1%); therefore, the random-effects model was utilized for analysis. Given the results, in many countries, the MYO15A gene had a significant contribution to hearing loss. Moreover, in several regions, specific dominant mutations in this gene have been reported. Therefore, the ethnic background should be considered to investigate the mutations of the MYO15A gene.
کلیدواژه‌ها
Autosomal recessive؛ Deafness؛ Meta-analysis؛ Mutation؛ MYO15A؛ Non-syndromic hearing loss؛ Prevalence
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