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Mohebbati, Reza, Hosseini, Mahmoud, Khazaei, Majid, Khajavirad, Abolfazl, Shafei, Mohammad Naser. (1399). Involvement of the 5-HT1A receptor of the cuneiform nucleus in the regulation of cardiovascular responses during normal and hemorrhagic conditions. , 23(7), 858-864. doi: 10.22038/ijbms.2020.40453.9579
Reza Mohebbati; Mahmoud Hosseini; Majid Khazaei; Abolfazl Khajavirad; Mohammad Naser Shafei. "Involvement of the 5-HT1A receptor of the cuneiform nucleus in the regulation of cardiovascular responses during normal and hemorrhagic conditions". , 23, 7, 1399, 858-864. doi: 10.22038/ijbms.2020.40453.9579
Mohebbati, Reza, Hosseini, Mahmoud, Khazaei, Majid, Khajavirad, Abolfazl, Shafei, Mohammad Naser. (1399). 'Involvement of the 5-HT1A receptor of the cuneiform nucleus in the regulation of cardiovascular responses during normal and hemorrhagic conditions', , 23(7), pp. 858-864. doi: 10.22038/ijbms.2020.40453.9579
Mohebbati, Reza, Hosseini, Mahmoud, Khazaei, Majid, Khajavirad, Abolfazl, Shafei, Mohammad Naser. Involvement of the 5-HT1A receptor of the cuneiform nucleus in the regulation of cardiovascular responses during normal and hemorrhagic conditions. , 1399; 23(7): 858-864. doi: 10.22038/ijbms.2020.40453.9579

Involvement of the 5-HT1A receptor of the cuneiform nucleus in the regulation of cardiovascular responses during normal and hemorrhagic conditions

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 23، شماره 7، مهر 2020، صفحه 858-864    اصل مقاله (835.51 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.40453.9579
نویسندگان
Reza Mohebbati1؛ Mahmoud Hosseini2؛ Majid Khazaei1؛ Abolfazl Khajavirad1؛ Mohammad Naser Shafei* 3
1Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): The 5-hydroxytryptamine1A (5-HT1A) receptor is one of the serotonin receptors in the brain, which regulates cardiovascular responses, especially in hemorrhage. Presence of this receptor in the cuneiform nucleus (CnF) has been shown. The present study evaluates the cardiovascular effect of this receptor of the CnF in normal and hypotensive hemorrhagic rats.
Materials and Methods: Agonist (8-OH-DPAT) and antagonist (WAY-100635) of 5-HT1A microinjected into the CnF in basal and hemorrhagic conditions and cardiovascular responses were evaluated. Hemorrhage induced by blood withdrawal from the femoral artery and 2 min after that drugs microinjected. Time course and peak changes (∆) of the mean arterial pressure (MAP), systolic blood pressure (SBP) and heart rate (∆HR) were obtained and compared to the control and hemorrhage groups.
Results: In basal condition, 8-OH-DPAT significantly decreased ∆SBP, ∆MAP and ∆HR compared to the control (P<0.05-P<0.01), while way-100635 did not have a significant effect. Hypotension and tachycardia induced by hemorrhage ameliorated by agonist (P<0.05-P<0.01), while antagonist deteriorated hypotension (P<0.05) but attenuated tachycardia (P<0.01).
Conclusion: This study shows that 5-HT1A receptor of the CnF involves in regulation of the cardiovascular responses. However, this effect in basal and hemorrhage conditions is different.
کلیدواژه‌ها
Hemorrhage؛ Mean arterial pressure؛ Medullary nucleus؛ Serotonin receptor؛ Systolic blood pressure
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