سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Nasri, Maryam, Mahdavifard, Sina, Babaeenezhad, Esmaeel, Adibhesami, Glavizh, Nouryazdan, Negar, Veiskarami, Saeid, Rahimi Monfared, Sobhan, Birjandi, Mehdi, Ahmadvand, Hassan. (1399). Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats. , 23(6), 714-723. doi: 10.22038/ijbms.2020.38553.9148
Maryam Nasri; Sina Mahdavifard; Esmaeel Babaeenezhad; Glavizh Adibhesami; Negar Nouryazdan; Saeid Veiskarami; Sobhan Rahimi Monfared; Mehdi Birjandi; Hassan Ahmadvand. "Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats". , 23, 6, 1399, 714-723. doi: 10.22038/ijbms.2020.38553.9148
Nasri, Maryam, Mahdavifard, Sina, Babaeenezhad, Esmaeel, Adibhesami, Glavizh, Nouryazdan, Negar, Veiskarami, Saeid, Rahimi Monfared, Sobhan, Birjandi, Mehdi, Ahmadvand, Hassan. (1399). 'Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats', , 23(6), pp. 714-723. doi: 10.22038/ijbms.2020.38553.9148
Nasri, Maryam, Mahdavifard, Sina, Babaeenezhad, Esmaeel, Adibhesami, Glavizh, Nouryazdan, Negar, Veiskarami, Saeid, Rahimi Monfared, Sobhan, Birjandi, Mehdi, Ahmadvand, Hassan. Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats. , 1399; 23(6): 714-723. doi: 10.22038/ijbms.2020.38553.9148

Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 23، شماره 6، شهریور 2020، صفحه 714-723    اصل مقاله (978.41 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.38553.9148
نویسندگان
Maryam Nasri1، 2؛ Sina Mahdavifard3؛ Esmaeel Babaeenezhad4؛ Glavizh Adibhesami1؛ Negar Nouryazdan5؛ Saeid Veiskarami6؛ Sobhan Rahimi Monfared1؛ Mehdi Birjandi7؛ Hassan Ahmadvand* 5، 8
1Department of Biochemistry and Genetics, Lorestan University of Medical Sciences, Khorramabad, Iran
2Growth and Development Research Center, Tehran University of Medical Science, Tehran, Iran
3Department of Clinical Biochemistry, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
4Department of Clinical Biochemistry, School of Medicine, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
6Agricultural and Natural Resources Research and Education Center, Department of Animal Science, Lorestan, Iran
7Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
8Razi Herbal Medicines Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
چکیده
Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.
Materials and Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used as an animal model of type 2 diabetes. One group of rats received daily His (1000 mg/l) in drinking water for 8 weeks, whereas other groups (control and untreated diabetic groups) received only water. Different parameters such as glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, and oxidative stress were determined in all groups. Moreover, renal histological alterations, mRNA expressions of anti-oxidant enzymes, and TNF-α were evaluated in the rats.
Results: His exhibited a protective effect on glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, oxidative stress, and TNF-α. Furthermore, His restored the renal histological alterations and normalized the augmented mRNA expressions of renal anti-oxidant enzymes (glutathione peroxidase (GPX) and Cu-Zn superoxide dismutase (Cu-Zn SOD)) and TNF-α.
Conclusion: His could ameliorate diabetes complications related to oxidative stress, inflammation, dyslipidemia, hyperglycemia, insulin resistance, and nephropathy. Hence, the use of this amino acid is recommended for diabetic patients in order to reduce diabetes complications.
کلیدواژه‌ها
Diabetic nephropathy؛ Gene expression؛ Histidine؛ Inflammation؛ Oxidative stress؛ Type 2 diabetes mellitus
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