Genetic Counseling for Families with Sporadic Intellectual Disability in North of Iran: A Retrospective Study | ||
| Journal of Pediatric Perspectives | ||
| مقاله 6، دوره 8، شماره 8 - شماره پیاپی 80، آبان 2020، صفحه 11709-11718 اصل مقاله (460.13 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijp.2020.47310.3840 | ||
| نویسندگان | ||
| Farzad Dastaviz1؛ Mohammad Bagher Hashemi- Soteh2؛ Peyman Aghabararian3؛ Saeed Zareei3؛ Saeed Dorgaleleh1؛ Moosa Rajabi Vandchali4؛ Mahsa Ghasempisheh4؛ Morteza Oladnabi5؛ Abouzar Bagheri* 2 | ||
| 1Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. | ||
| 2Department of Clinical Biochemistry and Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. | ||
| 3Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. | ||
| 4Sari Genetic Counseling Center, Welfare Office, Mazandaran, Iran. | ||
| 5Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran AND Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran AND Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran. | ||
| چکیده | ||
| Background Intellectual Disability (ID) is a heterogeneous disorder, in which at least 600 genes participate. The present study aimed to identify the effect of genetic counseling and consanguinity marriage in Iranian families with sporadic mental disability. Materials and Methods: In this retrospective cross-sectional study, we examined 151 families with a sporadic mental disability referred for genetic consultation to the Welfare Center of Sari city, North of Iran. Results: About 41.05% (n=62) of the cases were consanguinity marriage. In this study, other diseases were also observed with ID. The following four types of consultations were also reviewed, most of which were Diagnostic Counseling (DC) (60%). According to the inheritance pattern analysis, the share of non-hereditary cases was higher compared to the share of hereditary and unknown cases. The results of the present study showed a significant difference between consanguinity marriages and potential genetic etiology ID (P=0.012). Besides, there was no significant difference between other groups. Conclusion: In this study, we highlighted the importance of genetic counseling and found that consanguinity marriage was a key factor in the development of the disease in our society. Therefore, given the high cost of genetic tests and socio-economic problems, it is wise to include genetic counseling to prevent many diseases such as mental disability before birth. | ||
| کلیدواژهها | ||
| Consanguinity marriage, Genetic counseling؛ Intellectual disability, Iran, Sporadic | ||
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