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Francisco, Ngiambudulu, Allie, Nasiema, Sebesho, Boipelo, Ryffel, Bernhard, Jacobs, Muazzam. (1399). Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis. , 23(5), 680-690. doi: 10.22038/ijbms.2020.37947.9021
Ngiambudulu Francisco; Nasiema Allie; Boipelo Sebesho; Bernhard Ryffel; Muazzam Jacobs. "Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis". , 23, 5, 1399, 680-690. doi: 10.22038/ijbms.2020.37947.9021
Francisco, Ngiambudulu, Allie, Nasiema, Sebesho, Boipelo, Ryffel, Bernhard, Jacobs, Muazzam. (1399). 'Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis', , 23(5), pp. 680-690. doi: 10.22038/ijbms.2020.37947.9021
Francisco, Ngiambudulu, Allie, Nasiema, Sebesho, Boipelo, Ryffel, Bernhard, Jacobs, Muazzam. Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis. , 1399; 23(5): 680-690. doi: 10.22038/ijbms.2020.37947.9021

Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis

Iranian Journal of Basic Medical Sciences
مقاله 16، دوره 23، شماره 5، مرداد 2020، صفحه 680-690    اصل مقاله (1.56 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.37947.9021
نویسندگان
Ngiambudulu Francisco* 1، 2، 3؛ Nasiema Allie4؛ Boipelo Sebesho5؛ Bernhard Ryffel6؛ Muazzam Jacobs5، 7، 8
1Program of Infection and Immunity, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhongshan School of Medicine, Sun Yat-sen University, Guangdong, China
2Institute of Tuberculosis Control, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
3Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
4SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Stellenbosch, South Africa
5Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa
6Institut de Transgenose, CNRS, GEM2358, Orleans, France, University of Orleans and CNRS UMR7355, Experimental and Molecular Immunology and Neurogenetics, Orleans, France
7National Health Laboratory Service, Sandringham, Johannesburg, South Africa
8Immunology of Infectious Disease Research Unit, South African Medical Research Council, Cape Town 8000, South Africa
چکیده
Objective(s): This study aimed to explore the contribution of tumor necrosis factor (TNF) in the recruitment of B-cell and secretion of immunoglobulins (Igs) during cerebral tuberculosis (TB).
Materials and Methods: In this work, the contributing role of TNF in regulating Ig secretions was investigated by comparing wild type TNF (TNFf/f), B-cell-derived TNF (BTNF-/-), and complete TNF ablation (TNF-/-) in a mouse cerebral Mycobacterium tuberculosis infection. Using flow cytometry and ELISA, we were able to examine the recruitment of B-cell subsets, and the production of Igs; also assessed the expression of surface markers on B cell subsets.
Results: Here, we found that TNF-/- mice showed defective expression of IgA, IgG, and IgM antibodies compared with TNFf/f and BTNF-/- mice, which was significantly decreased in the expression of surface markers and co-stimulatory molecules. Moreover, mice that produced low antibody levels were not able to control infection, therefore progressed to disease; providing direct evidence for the TNF gene-regulating humoral immunity during central nervous system (CNS) M. tuberculosis infection. In contrast, BTNF-/- mice controlled the infection and had levels of IgA, IgG, and IgM comparable to TNFf/f mice.
Conclusion: Together, our results demonstrate that TNF may serve as an essential regulator of antibody-mediated immune responses in CNS TB. However, the protective level exhibited by TNF-producing B cells could be defined as baseline protection that could be used in the development of new therapeutic targets or designing new vaccines.
کلیدواژه‌ها
Antibody؛ Central nervous system؛ Humoral؛ Immunity infections؛ Mycobacterium؛ Tumor necrosis factor
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