سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Hassonizadeh Falahieh, Khadijeh, Sarkaki, Alireza, Edalatmanesh, Mohammadamin, Gharib Naseri, Mohammad Kazem, Farbood, Yaghoob. (1399). Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats. , 23(5), 645-653. doi: 10.22038/ijbms.2020.41821.9882
Khadijeh Hassonizadeh Falahieh; Alireza Sarkaki; Mohammadamin Edalatmanesh; Mohammad Kazem Gharib Naseri; Yaghoob Farbood. "Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats". , 23, 5, 1399, 645-653. doi: 10.22038/ijbms.2020.41821.9882
Hassonizadeh Falahieh, Khadijeh, Sarkaki, Alireza, Edalatmanesh, Mohammadamin, Gharib Naseri, Mohammad Kazem, Farbood, Yaghoob. (1399). 'Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats', , 23(5), pp. 645-653. doi: 10.22038/ijbms.2020.41821.9882
Hassonizadeh Falahieh, Khadijeh, Sarkaki, Alireza, Edalatmanesh, Mohammadamin, Gharib Naseri, Mohammad Kazem, Farbood, Yaghoob. Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats. , 1399; 23(5): 645-653. doi: 10.22038/ijbms.2020.41821.9882

Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats

Iranian Journal of Basic Medical Sciences
مقاله 12، دوره 23، شماره 5، مرداد 2020، صفحه 645-653    اصل مقاله (881.48 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.41821.9882
نویسندگان
Khadijeh Hassonizadeh Falahieh1، 2؛ Alireza Sarkaki* 3، 4؛ Mohammadamin Edalatmanesh2؛ Mohammad Kazem Gharib Naseri3؛ Yaghoob Farbood3
1Department of Physiology, College of Sciences, Science and Research Branch, Islamic Azad University, Fars, Iran
2Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
3Persian Gulf Physiology Research Center and Department of Physiology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
4Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
چکیده
Objective(s): Cerebral ischemia/reperfusion (I/R) causes brain inflammation that ultimately causes long time brain function disturbances. We aimed to evaluate the effect of ellagic acid (EA) on anxiety, depression, locomotion behaviors, blood-brain barrier (BBB) permeability, brain edema, and inflammation in male rats with cerebral I/R.
Materials and Methods: Sixty male Wistar rats (250-300 g) divided into 6 groups randomly with 10 in each: 1) Sham+Veh; rats submitted to the surgery without any I/R and received vehicle (10% DMSO in normal saline 5 ml/kg, gavages). 2) I/R+Veh; 3-5) I/R+EA; I/R rats received 50, 75 and 100 EA mg/kg, by gavages 3 times daily for one week. The cerebral I/R injury was induced by clamping the bilateral common carotid arteries for 20 minutes followed by reperfusion. Behaviors were tested one week after treatment, and brain tissue cytokines were measured by special ELISA kits.
Results: Cerebral I/R disrupted BBB function (P<0.001), increased brain water content (P<0.01), anxiety-like (P<0.001), depression-like (P<0.001) behaviors and cytokines in the brain tissue (P<0.001), while decreased locomotion and exploratory behaviors significantly (PConclusion: The results suggest that EA could be a potential therapeutic agent against cerebral I/R, possibly through its intertwined anti-inflammatory effects. Further research is required to investigate the involved mechanisms in details.
کلیدواژه‌ها
Anxiety-like behavior؛ BBB permeability؛ Brain edema؛ Cerebral ischemia/reperfusion؛ Cytokines؛ Depression-like behavior؛ Ellagic acid؛ Exploratory behaviors
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