Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 9، دوره 23، شماره 5، مرداد 2020، صفحه 623-628 اصل مقاله (740.56 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2020.35614.8492 | ||
| نویسندگان | ||
| Xiao Peng1؛ Xiuhe Pan1؛ Jun Tan2؛ Yan Li1؛ Mingcai Li* 1 | ||
| 1Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China | ||
| 2Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China | ||
| چکیده | ||
| Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mice were treated with IL-36Ra DNA or pcDNA3.1 control plasmid using a hydrodynamic gene delivery approach. Results: Our data reveal that treatment with IL-36Ra decreased liver inflammation and serum level of aminotransferases. Furthermore, IL-36Ra reduced ConA-induced pro-inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and IL-17A) production when compared to control plasmid. Conclusion: Our results demonstrated that IL-36Ra is a critical protector against ConA-induced liver injury. | ||
| کلیدواژهها | ||
| Concanavalin A (ConA)؛ Hydrodynamic-based gene delivery؛ IL-36Ra؛ Inflammation؛ Liver injury؛ Plasmid | ||
| مراجع | ||
|
| ||
|
آمار تعداد مشاهده مقاله: 1,014 تعداد دریافت فایل اصل مقاله: 720 |
||