The Efficacy of Paricalcitol Administration for Management of Pediatric Chronic Kidney Disease: A Systematic Review and Meta-analysis | ||
| Journal of Pediatric Perspectives | ||
| مقاله 14، دوره 8، شماره 2 - شماره پیاپی 74، اردیبهشت 2020، صفحه 10951-10959 اصل مقاله (698.01 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijp.2020.46747.3792 | ||
| نویسندگان | ||
| Mojtaba Fazel1؛ Sorour Khari2؛ Mohammed I. M. Gubari3؛ Neamatollah Ataei1؛ Mahmoud Yousefifard* 4؛ Mostafa Hosseini* 5 | ||
| 1Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Pediatrics, Valiasr Hospital, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 2Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. | ||
| 3Department of Family and Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq. | ||
| 4Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. | ||
| 5Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. | ||
| چکیده | ||
| Background There is still controversy about the efficacy of paricalcitol in children with chronic kidney disease (CKD). Therefore, the present study was designed to assess current evidence on the efficacy of paricalcitol in CKD children. Materials and Methods In this systematic review, an extensive search was performed on the databases of Medline, Embase, Scopus and Web of Science up to the end of October 2019. The keywords related to CKD and paricalcitol were combined and searched. Two independent researchers reviewed the papers; data were analyzed in STATA 14.0 statistical program and the effect of paricalcitol administration on serum levels of intact parathyroid hormone (iPTH), calcium (Ca), phosphorous (P), and Ca × P product ratio were reported as odds ratio (OR), and 95% confidence interval (95%CI). Results: Finally, data from three studies were included in the present study. Paricalcitol administration decreased iPTH levels in children with CKD (OR=0.12; 95%CI: 0.05 to 0.29; p<0.001). However, paricalcitol administration had no effect on serum calcium level (OR=1.16; 95%CI: 0.48 to 2.80; p=0.741), serum phosphorus level (OR=0.87; 95%CI: 0.38 to 1.99; p=0.735), and Ca × P ratio (OR=0.48; 95% CI: 0.15 to 1.50; p=0.208). No study has investigated the efficacy of paricalcitol on the control of proteinuria following CKD. Conclusion There is limited evidence on the efficacy and safety of paricalcitol in children with CKD. There are no studies in CKD children that have shown efficacy of Paricalcitol in controlling proteinuria. | ||
| کلیدواژهها | ||
| Chronic Kidney disease؛ Chronic؛ Paricalcitol؛ Renal Insufficiency؛ Vitamin D | ||
|
آمار تعداد مشاهده مقاله: 983 تعداد دریافت فایل اصل مقاله: 518 |
||