سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Rahimi Ghiasi, Moosa, Mohammadi, Hamed, Symonds, Michael, Tabei, Seyed Mohammad Bagher, Salehi, Ahmad Reza, Jafarpour, Sima, Norouzi Barough, Leila, Rahimi, Elnaz, Amirkhani, Zohreh, Miraghajani, Maryam, Salehi, Rasoul. (1399). Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies. , 23(4), 406-415. doi: 10.22038/ijbms.2020.39470.9359
Moosa Rahimi Ghiasi; Hamed Mohammadi; Michael Symonds; Seyed Mohammad Bagher Tabei; Ahmad Reza Salehi; Sima Jafarpour; Leila Norouzi Barough; Elnaz Rahimi; Zohreh Amirkhani; Maryam Miraghajani; Rasoul Salehi. "Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies". , 23, 4, 1399, 406-415. doi: 10.22038/ijbms.2020.39470.9359
Rahimi Ghiasi, Moosa, Mohammadi, Hamed, Symonds, Michael, Tabei, Seyed Mohammad Bagher, Salehi, Ahmad Reza, Jafarpour, Sima, Norouzi Barough, Leila, Rahimi, Elnaz, Amirkhani, Zohreh, Miraghajani, Maryam, Salehi, Rasoul. (1399). 'Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies', , 23(4), pp. 406-415. doi: 10.22038/ijbms.2020.39470.9359
Rahimi Ghiasi, Moosa, Mohammadi, Hamed, Symonds, Michael, Tabei, Seyed Mohammad Bagher, Salehi, Ahmad Reza, Jafarpour, Sima, Norouzi Barough, Leila, Rahimi, Elnaz, Amirkhani, Zohreh, Miraghajani, Maryam, Salehi, Rasoul. Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies. , 1399; 23(4): 406-415. doi: 10.22038/ijbms.2020.39470.9359

Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies

Iranian Journal of Basic Medical Sciences
مقاله 1، دوره 23، شماره 4، تیر 2020، صفحه 406-415    اصل مقاله (719.46 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.39470.9359
نویسندگان
Moosa Rahimi Ghiasi1؛ Hamed Mohammadi2؛ Michael Symonds3؛ Seyed Mohammad Bagher Tabei4؛ Ahmad Reza Salehi1؛ Sima Jafarpour1؛ Leila Norouzi Barough1؛ Elnaz Rahimi1؛ Zohreh Amirkhani1؛ Maryam Miraghajani5، 6؛ Rasoul Salehi* 1، 7
1Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
3The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
4Department of Genetics & Maternal-Fetal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
63 The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
7Gerfa Namayesh Azmayesh (GENAZMA) Science and Research Institute, Isfahan, Iran
چکیده
Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose tolerance test (IPGTT), fasting blood glucose, and insulin in animals with type 1 DM.
Materials and Methods: The Cochrane Library, PubMed, Embase, ISI Web of Science, SCOPUS, and Google Scholar were systematically searched for potentially relevant studies. Mean±standard deviation (SD) was pooled using a random-effects model.
Results: After the primary search, out of 528 studies identified, 16 studies were in concordance with predefined criteria and selected for the final assessment. Of these, 12 studies used viral manipulation, and 4 employed non-viral vectors for gene delivery. The meta-analysis showed gene therapy with a viral vector decreased mean IPGTT (-12.69 mmol/l, P<0.001), fasting blood glucose (-13.51 mmol/l, P<0.001), insulin (398.28 pmol/l, P<0.001), and bodyweight (24.22 g, P<0.001), whereas non-viral vectors reduced fasting glucose (-29.95 mmol/l, P<0.001) and elevated insulin (114.92 pmol/l, P<0.001).
Conclusion: Gene therapy has favorable effects on alleviating type 1 DM related factors in diabetic rodents.
کلیدواژه‌ها
Gene therapy؛ Insulin؛ Meta-analysis؛ Non-viral vector؛ Type 1 diabetes mellitus؛ Viral vector
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