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gholamian, samira, Attarzadeh Hosseini, Seyyed Reza, Rashidlamir, Amir, Aghaalinjad, Hamid. (1398). The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer. , 23(2), 244-250. doi: 10.22038/ijbms.2019.39535.9375
samira gholamian; Seyyed Reza Attarzadeh Hosseini; Amir Rashidlamir; Hamid Aghaalinjad. "The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer". , 23, 2, 1398, 244-250. doi: 10.22038/ijbms.2019.39535.9375
gholamian, samira, Attarzadeh Hosseini, Seyyed Reza, Rashidlamir, Amir, Aghaalinjad, Hamid. (1398). 'The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer', , 23(2), pp. 244-250. doi: 10.22038/ijbms.2019.39535.9375
gholamian, samira, Attarzadeh Hosseini, Seyyed Reza, Rashidlamir, Amir, Aghaalinjad, Hamid. The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer. , 1398; 23(2): 244-250. doi: 10.22038/ijbms.2019.39535.9375

The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 23، شماره 2، اردیبهشت 2020، صفحه 244-250    اصل مقاله (569.91 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.39535.9375
نویسندگان
samira gholamian1؛ Seyyed Reza Attarzadeh Hosseini* 2؛ Amir Rashidlamir3؛ Hamid Aghaalinjad4
1Department of Exercise Physiology (Biochemistry and Metabolism), Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2Department of Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
4Department of Sports Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
چکیده
Objective(s): It seems that regular exercise can have inhibitory effects on the progression of breast cancer. This study, therefore, aimed to investigate the influences of interval aerobic training on mesenchymal biomarker gene expression, muscle cachexia, and tumor volume changes in mice with breast cancer.
Materials and Methods: Thirty-two female Balb/c mice were allocated to four groups: Exercise Tumor Exercise, Rest Tumor Rest (Control), Rest Tumor Exercise, and Exercise Tumor Rest. Interval aerobic training was done 6 weeks before and 4 weeks after tumor induction. Weight test and inverted screen test were carried out as muscle function tests. Data were analyzed using one-way ANOVA and HSD post hoc.
Results: The results showed a significant decrease in gene expressions of Twist, Vimentin, and TGF-β in Exercise Tumor Exercise group in comparison with the Control group (P<0.05). Remarkable reduction of the rate of tumor volume was also observed in two training groups (Rest Tumor Exercise, Exercise Tumor Exercise) compared with the control group. According to function tests’ results, muscle functions were diminished due to cancer, but interval aerobic training can keep muscles in a normally-functioning state in cancer (P<0.05).
Conclusion: Considering final results, a period of interval aerobic training can be used not only as a prevention method, but also help cancer treatment and impede cachexia by tumor volume reduction, decrease mesenchymal biomarker gene expression, and increase muscle strength functions.
کلیدواژه‌ها
Breast cancer؛ Cachexia؛ Interval aerobic training؛ TGF-β؛ Tumor Volume؛ Twist؛ Vimentin
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