سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Moazzen, Nasrin, Ahanchian, Hamid, Jabbari Azad, Farahzad, Mohammadi, Mojgan, Farid, Reza, Nikpoor, Amin reza, Salehi, Maryam, Khoshkhui, Maryma. (1398). Subcutaneous Immunotherapy and Synbiotic Combination Shift T-Helper 1 and Cytotoxic T Cells in Allergic Rhinitis. , 8(1), 10731-10742. doi: 10.22038/ijp.2019.14040
Nasrin Moazzen; Hamid Ahanchian; Farahzad Jabbari Azad; Mojgan Mohammadi; Reza Farid; Amin reza Nikpoor; Maryam Salehi; Maryma Khoshkhui. "Subcutaneous Immunotherapy and Synbiotic Combination Shift T-Helper 1 and Cytotoxic T Cells in Allergic Rhinitis". , 8, 1, 1398, 10731-10742. doi: 10.22038/ijp.2019.14040
Moazzen, Nasrin, Ahanchian, Hamid, Jabbari Azad, Farahzad, Mohammadi, Mojgan, Farid, Reza, Nikpoor, Amin reza, Salehi, Maryam, Khoshkhui, Maryma. (1398). 'Subcutaneous Immunotherapy and Synbiotic Combination Shift T-Helper 1 and Cytotoxic T Cells in Allergic Rhinitis', , 8(1), pp. 10731-10742. doi: 10.22038/ijp.2019.14040
Moazzen, Nasrin, Ahanchian, Hamid, Jabbari Azad, Farahzad, Mohammadi, Mojgan, Farid, Reza, Nikpoor, Amin reza, Salehi, Maryam, Khoshkhui, Maryma. Subcutaneous Immunotherapy and Synbiotic Combination Shift T-Helper 1 and Cytotoxic T Cells in Allergic Rhinitis. , 1398; 8(1): 10731-10742. doi: 10.22038/ijp.2019.14040

Subcutaneous Immunotherapy and Synbiotic Combination Shift T-Helper 1 and Cytotoxic T Cells in Allergic Rhinitis

Journal of Pediatric Perspectives
مقاله 8، دوره 8، شماره 1 - شماره پیاپی 73، فروردین 2020، صفحه 10731-10742    اصل مقاله (395.97 K)
شناسه دیجیتال (DOI): 10.22038/ijp.2019.14040
نویسندگان
Nasrin Moazzen1؛ Hamid Ahanchian2؛ Farahzad Jabbari Azad* 2؛ Mojgan Mohammadi2؛ Reza Farid3؛ Amin reza Nikpoor4؛ Maryam Salehi5؛ Maryma Khoshkhui1
1Assistant Professor, Department of Pediatric Immunology and Allergy, Akbar Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2Associate Professor, Department of Pediatric Immunology and Allergy, Akbar Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3Professor, Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4PhD, Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5Associate Professor, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Background: Synbiotics have been used in the prevention and treatment of various immunological diseases. We aimed to investigate the synergistic clinical and immunologic effects of synbiotics and subcutaneous allergen immunotherapy (SCIT) combination in patients with allergic rhinitis.
Materials and Methods: Nineteen individuals with allergic rhinitis were enrolled in this single blind, placebo-controlled trial between 2015 and 2016 in Qaem Hospital, Mashhad, Iran. Patients were randomly divided into two groups: A) Immunotherapy plus one synbiotic capsule per day, and B) Immunotherapy plus placebo for two months. The Sino-nasal outcome test (SNOT-22), and mini rhinoconjunctivitis quality of life questionnaire (RQLQ) were filled by patients or their parents while intracellular expression of interlukin-4 (IL-4), interferon-gamma (IFN-gamma), and Forkhead Box P3 (FOXP3), and variations in the T helper 1 (Th1), T helper 2 (Th2) and T regulatory cells and cytotoxic T lymphocytes (CTL) frequency were examined by flow cytometry assay at baseline, after 2 and 6 months of intervention.
Results: Nineteen individuals with allergic rhinitis aged between 5 and 55 years participated in this study. No significant difference in the frequency of symptoms between the two groups was observed after 2 and 6 months of intervention (p>0.05). A significant increase in the percentage of Th1 cells was recorded in group A compared to group B (p= 0.02). CTL enhancement percentage was significantly increased in group A compared to group B after 2 months (p=0.013).
Conclusion: Subcutaneous Immunotherapy concomitant with synbiotics administration may have temporarily increased the percentage of Th1 cells, but no significant clinical differences were observed.
کلیدواژه‌ها
Allergic rhinitis؛ Synbiotics؛ Probiotics؛ Subcutaneous allergen immunotherapy
آمار
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