سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Shaaban, Zahra, Khoradmehr, Arezoo, Amiri-Yekta, Amir, Jafarzadeh Shirazi, Mohammad Reza, Tamadon, Amin. (1398). Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome. , 22(12), 1378-1386. doi: 10.22038/ijbms.2019.14029
Zahra Shaaban; Arezoo Khoradmehr; Amir Amiri-Yekta; Mohammad Reza Jafarzadeh Shirazi; Amin Tamadon. "Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome". , 22, 12, 1398, 1378-1386. doi: 10.22038/ijbms.2019.14029
Shaaban, Zahra, Khoradmehr, Arezoo, Amiri-Yekta, Amir, Jafarzadeh Shirazi, Mohammad Reza, Tamadon, Amin. (1398). 'Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome', , 22(12), pp. 1378-1386. doi: 10.22038/ijbms.2019.14029
Shaaban, Zahra, Khoradmehr, Arezoo, Amiri-Yekta, Amir, Jafarzadeh Shirazi, Mohammad Reza, Tamadon, Amin. Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome. , 1398; 22(12): 1378-1386. doi: 10.22038/ijbms.2019.14029

Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 22، شماره 12، اسفند 2019، صفحه 1378-1386    اصل مقاله (680.57 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.14029
نویسندگان
Zahra Shaaban1؛ Arezoo Khoradmehr2؛ Amir Amiri-Yekta3؛ Mohammad Reza Jafarzadeh Shirazi1؛ Amin Tamadon* 4
1Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran
2Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran
4The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
چکیده
Objective(s): One of the common heterogeneous reproductive disorders in women of childbearing age is polycystic ovary syndrome (PCOS). It is characterized by lack of fertility due to anovulatory cycles, hyperandrogenemia, polycystic ovaries, hyperinsulinemia, and obesity. Both reproductive anomalies and metabolic disorders are involved in PCOS pathology. Although the role of increased levels of androgens in initiation of PCOS is almost proven, mechanisms of PCOS pathophysiology are not clear. Here we discuss roles of altered metabolic conditions, obesity, and chronic inflammation in PCOS pathophysiology.
Materials and Methods: In this review, we attempted to identify genes related to obesity and chronic inflammation aspects of PCOS and their physiological functions to explain the pathways that are regulated by these genes and can be a prominent function in PCOS predisposition. For this purpose, published articles and reviews dealing with genetic evaluation of PCOS in women in peer-reviewed journals in PubMed and Google Scholar databases were included in this review.
Results: Obesity and chronic inflammation are not prominent diagnostic features of PCOS, but they play an important role in exacerbating metabolic and hyperandrogenic states. ADIPOQ, FTO TGFβ, and DENND1A as the main obesity- and chronic inflammation-related genes have roles in PCOS pathophysiology.
Conclusion: It seems that genes related to obesity pathology in genomic research association, are related to metabolic aspects and body mass index in PCOS patients. Genomes have roles in chronic inflammation, followed by obesity, in the pathogenesis of PCOS.
کلیدواژه‌ها
Chronic inflammation؛ Gene؛ Obesity؛ Pathophysiology؛ Polycystic ovary syndrome
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