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Vakili-Ghartavol, Roghayyeh, Jaafari, Mahmoud Reza, Nikpoor, Amin Reza, Rezayat, Seyed Mahdi. (1399). Docetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies. , 7(2), 108-114. doi: 10.22038/nmj.2020.07.003
Roghayyeh Vakili-Ghartavol; Mahmoud Reza Jaafari; Amin Reza Nikpoor; Seyed Mahdi Rezayat. "Docetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies". , 7, 2, 1399, 108-114. doi: 10.22038/nmj.2020.07.003
Vakili-Ghartavol, Roghayyeh, Jaafari, Mahmoud Reza, Nikpoor, Amin Reza, Rezayat, Seyed Mahdi. (1399). 'Docetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies', , 7(2), pp. 108-114. doi: 10.22038/nmj.2020.07.003
Vakili-Ghartavol, Roghayyeh, Jaafari, Mahmoud Reza, Nikpoor, Amin Reza, Rezayat, Seyed Mahdi. Docetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies. , 1399; 7(2): 108-114. doi: 10.22038/nmj.2020.07.003

Docetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies

Nanomedicine Journal
مقاله 3، دوره 7، شماره 2، تیر 2020، صفحه 108-114    اصل مقاله (595.76 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2020.07.003
نویسندگان
Roghayyeh Vakili-Ghartavol1؛ Mahmoud Reza Jaafari2، 3؛ Amin Reza Nikpoor4؛ Seyed Mahdi Rezayat* 1، 5
1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
4Molecular Medicine Research Center Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
5Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): Folate-targeted liposomes have been well considered in folate receptor (FR) overexpressing cells including MCF-7 and 4T1 cells in vitro and in vivo. The objective of this study is to design an optimum folate targeted liposomal formulations which show the best liposome cell uptake to tumor cells.
Material and Methods: In this study, we prepared and characterized different targeted formulations and a nontargeted form as a control. Physicochemical analysis showed that the liposomes had homogeneous population and appropriate size to accumulate to tumor sites through the enhanced permeation and retention (EPR) mechanism. Moreover, we compared the cell uptake of folate targeted liposomal docetaxel compared to nontargeted liposomes in vitro.
Results: The in vitro drug release profile of the formulations at different time points showed none of the formulations did not has burst release. However, targeted liposomes accumulated in tumor tissue in vivo less than nontargeted formulations which could be attributed to their uptake by RES due to relatively greater size of targeted formulations. It is presumable that analyze the biodistribution process at longer time points and the molecular mechanisms behind the tissue accumulation could clear the issue.
Conclusion: We conclude that success in vitro studies holds the promise of folate targeting strategy and in vivo study merits further investigations.
کلیدواژه‌ها
Docetaxel Encapsulation؛ Folate Targeting؛ Liposomes؛ Tumor Drug Delivery
مراجع

1. Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin Y, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M,Huynh T,Hynes R, Freeman G, Kroemer G, Zitvogel L, Weissleder R, Pittet M. Immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy. Immunity. 2016; 44: 343-354.
2. Cai X, Jia X, Gao W, Zhang K, Ma M, Wang S, Zheng Y, Shi J , Chen H. A Versatile Nanotheranostic Agent for Efficient Dual‐Mode Imaging Guided Synergistic Chemo‐Thermal Tumor Therapy. Adv Funct Mater. 2015; 25: 2520-2529.
3. Long D, Liu T, Tan L, Shi H, Liang P, Tang S, Yu J, Dou J, Meng X. Multisynergistic platform for tumor therapy by mild microwave irradiation-activated chemotherapy and enhanced ablation. ACS nano. 2016; 10: 9516-9528.
4. Zhang L, Su H, Cai J, Cheng D, Ma Y, Zhang J, Zhou C, Liu S, Shi H, Zhang Y, Zhang C. A multifunctional platform for tumor angiogenesis-targeted chemo-thermal therapy using polydopamine-coated gold nanorods. ACS nano. 2016; 10(11): 10404-10417.
5. Riviere K, Huang Z, Jerger K, Macaraeg N, Szoka Jr FC. Antitumor effect of folate-targeted liposomal doxorubicin in KB tumor-bearing mice after intravenous administration. J Drug Target. 2011; 19: 14-24.
6. Yi Q, Ma J, Kang K, Gu Z. Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy. Int J Nanomed. 2018; 13: 653.
7. Guo F, Yu M, Wang J, Tan F, Li N. Smart IR780 theranostic nanocarrier for tumor-specific therapy: hyperthermia-mediated bubble-generating and folate-targeted liposomes. ACS Appl Mater Interfaces. 2015; 7: 20556-20567.
8. Lu Y, Low PS. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv. Drug Deliv Rev. 2012; 64: 342-352.
9. Leamon CP, Reddy JA. Folate-targeted chemotherapy. Adv Drug Deliv Rev. 2004; 56: 1127-1141.
10. Patil Y, Shmeeda H, Amitay Y, Ohana P, Kumar S, Gabizon A. Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA). Nanomedicine. 2018; 14: 1407-1416.
11. Patil Y, Amitay Y, Ohana P, Shmeeda H, Gabizon A. Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: Intracellular activation and enhanced cytotoxicity. J Control Release. 2016; 225: 87-95.
12. Zhai G, Wu J, Xiang G, Mao W, Yu B, Li H, Piao L, Lee LJ, Lee, RJ. Preparation, characterization and pharmacokinetics of folate receptor-targeted liposomes for docetaxel delivery. J Nanosci Nanotechnol. 2009; 9: 2155-2161.
13. Kumar P, Huo P, Liu B. Formulation Strategies for Folate-Targeted Liposomes and Their Biomedical Applications. Pharmaceutics. 2019; 11: 381.
14. Goren D, Horowitz AT, Tzemach D, Tarshish M, Zalipsky S, Gabizon A. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin. Cancer Res. 2000; 6: 1949-1957.
15. Alibolandi M, Abnous K, Sadeghi F, Hosseinkhani H, Ramezani M, Hadizadeh F. Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: in vitro and in vivo evaluation. Int J Pharm. 2016; 500: 162-178.
16. Nikpoor AR, Tavakkol-Afshari J, Gholizadeh Z, Sadri K, Babaei MH, Chamani J, Badiee A, Jalali SA, JaafarI MR. Nanoliposome-mediated targeting of antibodies to tumors: IVIG antibodies as a model. Int J Pharm. 2015; 495: 162-170.
17. Tanhaeian A, Jaafari MR, Ahmadi FS, Vakili‐Ghartavol R, Sekhavati MH. Secretory expression of a chimeric peptide in Lactococcus lactis: assessment of its cytotoxic activity and a deep view on its interaction with cell-surface glycosaminoglycans by molecular modeling. Probiotics & Antimicro Prot. 2019; 11: 1034-1041.
18. Nikpoor AR, Tavakkol-Afshari J, Sadri K, Jalali SA, Jaafari MR. Improved tumor accumulation and therapeutic efficacy of CTLA-4-blocking antibody using liposome-encapsulated antibody: In vitro and in vivo studies. Nanomedicine. 2017; 13: 2671-2682.
19. Zahmatkeshan M, Gheybi F, Rezayat SM, Jaafari MR. Improved drug delivery and therapeutic efficacy of PEgylated liposomal doxorubicin by targeting anti-HER2 peptide in murine breast tumor model. Eur J Pharm Sci. 2016; 86: 125-135.
20. Amin M, Bagheri M, Mansourian M, Jaafari MR, ten Hagen TL. Regulation of in vivo behavior of TAT-modified liposome by associated protein corona and avidity to tumor cells. Int J Nanomedicine. 2018; 13:7441.
21. Arabi L, Badiee A, Mosaffa F, Jaafari MR. Targeting CD44 expressing cancer cells with anti-CD44 monoclonal antibody improves cellular uptake and antitumor efficacy of liposomal doxorubicin. J Control Release. 2015; 220: 275-286.
22. Wang L, Li M, Zhang N. Folate-targeted docetaxel-lipid-based-nanosuspensions for active-targeted cancer therapy. Int J Nanomed. 2012; 7: 3281.
23. Awasthi V, Garcia D, Goins B, Phillips WT. Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits. Int J Pharm. 2003; 253: 121-132.
24. Fisher ML, Colic M, Rao MP, Lange FF. Effect of silica nanoparticle size on the stability of alumina/silica suspensions. J Am Ceram Soc. 2001; 84: 713-718.
25. Mozafari MR, Khosravi-Darani K, Borazan GG, Cui J, Pardakhty A, Yurdugul S. Encapsulation of food ingredients using nanoliposome technology. International Journal of Food Properties. 2008; 11: 833-844.

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