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Golshahi, Hannaneh, Araghi, Atefeh, Baghban, Farshad, Farzad-Mohajeri, Saeed. (1398). Protective effects of 2-methoxycinnamaldehyde an active ingredients of Cinnamomum cassia on warm hepatic ischemia reperfusion injury in rat model. , 22(12), 1400-1407. doi: 10.22038/ijbms.2019.13987
Hannaneh Golshahi; Atefeh Araghi; Farshad Baghban; Saeed Farzad-Mohajeri. "Protective effects of 2-methoxycinnamaldehyde an active ingredients of Cinnamomum cassia on warm hepatic ischemia reperfusion injury in rat model". , 22, 12, 1398, 1400-1407. doi: 10.22038/ijbms.2019.13987
Golshahi, Hannaneh, Araghi, Atefeh, Baghban, Farshad, Farzad-Mohajeri, Saeed. (1398). 'Protective effects of 2-methoxycinnamaldehyde an active ingredients of Cinnamomum cassia on warm hepatic ischemia reperfusion injury in rat model', , 22(12), pp. 1400-1407. doi: 10.22038/ijbms.2019.13987
Golshahi, Hannaneh, Araghi, Atefeh, Baghban, Farshad, Farzad-Mohajeri, Saeed. Protective effects of 2-methoxycinnamaldehyde an active ingredients of Cinnamomum cassia on warm hepatic ischemia reperfusion injury in rat model. , 1398; 22(12): 1400-1407. doi: 10.22038/ijbms.2019.13987

Protective effects of 2-methoxycinnamaldehyde an active ingredients of Cinnamomum cassia on warm hepatic ischemia reperfusion injury in rat model

Iranian Journal of Basic Medical Sciences
مقاله 5، دوره 22، شماره 12، اسفند 2019، صفحه 1400-1407    اصل مقاله (1.2 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.13987
نویسندگان
Hannaneh Golshahi1؛ Atefeh Araghi* 2؛ Farshad Baghban3؛ Saeed Farzad-Mohajeri4، 5
1Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
2Department of Clinical Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
3Department of Veterinary Medicine, Yasooj Branch, Islamic Azad University, Yasooj, Iran
4Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
5Institute of Biomedical Research, University of Tehran, Tehran, Iran
چکیده
Objective(s): Hepatic ischemia/reperfusion injury (IRI) is one of the major causes of hepatic failure during liver transplantation, trauma, and infections. The present study investigated the protective effect of intra-portal administration of 2-methoxycinnamaldehyde (2-MCA) on hepatic IRI in rats.
Materials and Methods: Twenty-four rats were equally divided into four groups; 1) sham group, (no IRI or transfusion), 2) Hepatic IRI (60 min ischemia + 120 min reperfusion, 3) Hepatic IRI+ NS (IRI + normal saline), 4) Hepatic IRI+2-MCA, (IRI + 2-MCA). In groups 3 and 4, 1 ml/kg normal saline and 2-MCA were administered slowly into the vein of the left lateral and median lobes of the liver 10 min before induction of hepatic reperfusion (upper the site of clumping), respectively. The harvest time points were at 2 hours post-reperfusion in all groups.
Results: Histologically, cell death, degenerative changes, sinusoidal dilatation, congestion, hemorrhage, and infiltration of inflammatory cells were observed in IRI group, while these pathological changes were attenuated in the 2-MCA administrated group. The level of alanine transaminase, aspartate transaminase, tumor necrosis factor- α and interleukin-6 in serum and hepatic malondialdehyde were significantly increased by IRI, and 2-MCA administration reduced all these markers. In addition, caspase-3 and nuclear factor κB (NF-κB) expression were investigated immunohistochemically. Administration of 2-MCA considerably decreased caspase-3 positive cells and NF-κB activity in comparison with IRI group.
Conclusion: As a conclusion, in situ administration of 2-MCA protects against hepatic IRI via anti-inflammatory, and anti-apoptotic properties.
کلیدواژه‌ها
Ischemia reperfusion injury؛ Liver؛ Oxidative stress؛ Rat؛ 2-Methoxycinnamaldehyde
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