سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mirzaei, Mehdi, Esmaeil Akbari, Mohammad, Mohagheghi, Mohammad Ali, Ziaee, Seyed Amir Mohsen, Mohseni, Mojdeh. (1398). A Novel Biocompatible Nanoprobe Based on Lipoproteins for Breast Cancer Cell Imaging. , 7(1), 73-79. doi: 10.22038/nmj.2020.07.09
Mehdi Mirzaei; Mohammad Esmaeil Akbari; Mohammad Ali Mohagheghi; Seyed Amir Mohsen Ziaee; Mojdeh Mohseni. "A Novel Biocompatible Nanoprobe Based on Lipoproteins for Breast Cancer Cell Imaging". , 7, 1, 1398, 73-79. doi: 10.22038/nmj.2020.07.09
Mirzaei, Mehdi, Esmaeil Akbari, Mohammad, Mohagheghi, Mohammad Ali, Ziaee, Seyed Amir Mohsen, Mohseni, Mojdeh. (1398). 'A Novel Biocompatible Nanoprobe Based on Lipoproteins for Breast Cancer Cell Imaging', , 7(1), pp. 73-79. doi: 10.22038/nmj.2020.07.09
Mirzaei, Mehdi, Esmaeil Akbari, Mohammad, Mohagheghi, Mohammad Ali, Ziaee, Seyed Amir Mohsen, Mohseni, Mojdeh. A Novel Biocompatible Nanoprobe Based on Lipoproteins for Breast Cancer Cell Imaging. , 1398; 7(1): 73-79. doi: 10.22038/nmj.2020.07.09

A Novel Biocompatible Nanoprobe Based on Lipoproteins for Breast Cancer Cell Imaging

Nanomedicine Journal
مقاله 9، دوره 7، شماره 1، فروردین 2020، صفحه 73-79    اصل مقاله (696.72 K)
شناسه دیجیتال (DOI): 10.22038/nmj.2020.07.09
نویسندگان
Mehdi Mirzaei* 1، 2؛ Mohammad Esmaeil Akbari1؛ Mohammad Ali Mohagheghi3؛ Seyed Amir Mohsen Ziaee4؛ Mojdeh Mohseni5
1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Iran Ministry of Health and Medical Education, Deputy Ministry for Education, Tehran, Iran
3Cancer Institute Research Center, Tehran University of Medical Sciences, Tehran, Iran
4Labbafinejad Medical Center, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): Contrast-enhanced magnetic resonance imaging (MRI) of breast cancer provides valuable data on the disease state of patients. Biocompatible nanoprobes are expected to play a pivotal role in medical diagnosis in the future owing to their prominent advantages. The present study aimed to introduce a novel biocompatible nanoprobe based on lipoproteins for breast cancer cell imaging.
Materials and Methods: In this study, a biocompatible nanoprobe based on high-density lipoprotein was synthesized successfully. Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS) were used for material characterization, and cellular uptake and in-vitro and in-vivo imaging were investigated using the nanoprobe.
Results: The nanoprobe could significantly reduce the relaxation time in the phantom and cancer cells with no toxicity in the studied cells. In addition, the nanoprobe demonstrated proper cellular uptake in the cancer cells. The in-vivo tumor images were obtained 30, 60, and 120 minutes after the injection of the nanoprobe (5.0 µmol/kg) via the tail vein, and the results indicated that the synthesized nanoprobe could be introduced as a potential MRI contrast agent.
Conclusion: Future developments may allow the application of this nanoparticle to be used in pathological and physiological processes in preclinical models.
کلیدواژه‌ها
Breast Cancer؛ Contrast Agent؛ High-density Lipoprotein؛ Nanoprobe
مراجع

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