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El Menyiy, Nawal, Al-Waili, Noori, El Ghouizi, Asmae, El-Guendouz, Soukaina, Salom, Khelod, Lyoussi, Badiaa. (1398). Potential therapeutic effect of Moroccan propolis in hyperglycemia, dyslipidemia, and hepatorenal dysfunction in diabetic rats. , 22(11), 1331-1339. doi: 10.22038/ijbms.2019.33549.8004
Nawal El Menyiy; Noori Al-Waili; Asmae El Ghouizi; Soukaina El-Guendouz; Khelod Salom; Badiaa Lyoussi. "Potential therapeutic effect of Moroccan propolis in hyperglycemia, dyslipidemia, and hepatorenal dysfunction in diabetic rats". , 22, 11, 1398, 1331-1339. doi: 10.22038/ijbms.2019.33549.8004
El Menyiy, Nawal, Al-Waili, Noori, El Ghouizi, Asmae, El-Guendouz, Soukaina, Salom, Khelod, Lyoussi, Badiaa. (1398). 'Potential therapeutic effect of Moroccan propolis in hyperglycemia, dyslipidemia, and hepatorenal dysfunction in diabetic rats', , 22(11), pp. 1331-1339. doi: 10.22038/ijbms.2019.33549.8004
El Menyiy, Nawal, Al-Waili, Noori, El Ghouizi, Asmae, El-Guendouz, Soukaina, Salom, Khelod, Lyoussi, Badiaa. Potential therapeutic effect of Moroccan propolis in hyperglycemia, dyslipidemia, and hepatorenal dysfunction in diabetic rats. , 1398; 22(11): 1331-1339. doi: 10.22038/ijbms.2019.33549.8004

Potential therapeutic effect of Moroccan propolis in hyperglycemia, dyslipidemia, and hepatorenal dysfunction in diabetic rats

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 22، شماره 11، بهمن 2019، صفحه 1331-1339    اصل مقاله (498.82 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.33549.8004
نویسندگان
Nawal El Menyiy1؛ Noori Al-Waili* 2؛ Asmae El Ghouizi1؛ Soukaina El-Guendouz1؛ Khelod Salom2؛ Badiaa Lyoussi1
1Laboratory Physiology-Pharmacology & Environmental Health, Faculty of science Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco
2New York Medical Care for Nephrology, New York City, NY, USA
چکیده
Objective(s): The effect of propolis collected in Morocco on blood glucose, lipid profile, liver enzymes, and kidney function was investigated in control and diabetic rats.  
Materials and Methods: Antioxidant activity of propolis was evaluated with the use of DPPH, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+), ferric reducing power and total antioxidant activity assay. To study its effect in streptozotocin (STZ)-induced diabetes, the rats were divided into eight groups; four control and four diabetics. The animals received distilled water, glibenclamide, or propolis extract, 50 mg/kg/BW) or 100 mg/kg/b.wt, daily for 15 days. Blood glucose, triglyceride, lactic acid dehydrogenase, liver enzymes, creatinine, blood urea, lipid profile, and body weight were measured on day 15 after commencement of the treatment.
Results: Propolis has a strong antioxidant activity and high total flavonoids and polyphenols content. Glibenclamide and propolis have no significant effect on lipid parameters, and renal and hepatic function in non-diabetic rats. However, propolis or glibenclamide caused a significant lowering of blood glucose after a single administration and at day 15 after daily administration in diabetic rats (P<0.05). Both interventions significantly lowered lactic acid dehydrogenase, increased body weight, and ameliorated dyslipidemia and abnormal liver and kidney function caused by diabetes. The effect of propolis was dose-dependent and in a high dose it was more potent than glibenclamide.
Conclusion: Propolis exhibited strong antihyperglycemic, antihyperlipidemic, and hepato-renal protective effects in diabetes, and significantly lowered the elevated lactic acid dehydrogenase. The study demonstrated for the first-time the effect of Moroccan propolis in diabetes and it will pave the way for clinical investigations.
کلیدواژه‌ها
Antioxidant؛ Diabetes؛ Kidney؛ Liver؛ Propolis
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