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Rafeey, Mandana, Nikniaz, Zeinab, FarshiRadvar, Fatemeh, Sameni, Ziba, Faramarzi, Elnaz. (1399). Effects of Curcumin Supplementation on Quality of Life of Cystic Fibrosis Patients. , 8(4), 11169-11176. doi: 10.22038/ijp.2019.42990.3602
Mandana Rafeey; Zeinab Nikniaz; Fatemeh FarshiRadvar; Ziba Sameni; Elnaz Faramarzi. "Effects of Curcumin Supplementation on Quality of Life of Cystic Fibrosis Patients". , 8, 4, 1399, 11169-11176. doi: 10.22038/ijp.2019.42990.3602
Rafeey, Mandana, Nikniaz, Zeinab, FarshiRadvar, Fatemeh, Sameni, Ziba, Faramarzi, Elnaz. (1399). 'Effects of Curcumin Supplementation on Quality of Life of Cystic Fibrosis Patients', , 8(4), pp. 11169-11176. doi: 10.22038/ijp.2019.42990.3602
Rafeey, Mandana, Nikniaz, Zeinab, FarshiRadvar, Fatemeh, Sameni, Ziba, Faramarzi, Elnaz. Effects of Curcumin Supplementation on Quality of Life of Cystic Fibrosis Patients. , 1399; 8(4): 11169-11176. doi: 10.22038/ijp.2019.42990.3602

Effects of Curcumin Supplementation on Quality of Life of Cystic Fibrosis Patients

Journal of Pediatric Perspectives
مقاله 8، دوره 8، شماره 4 - شماره پیاپی 76، تیر 2020، صفحه 11169-11176    اصل مقاله (324.69 K)
شناسه دیجیتال (DOI): 10.22038/ijp.2019.42990.3602
نویسندگان
Mandana Rafeey1؛ Zeinab Nikniaz2؛ Fatemeh FarshiRadvar3؛ Ziba Sameni4؛ Elnaz Faramarzi* 5
1MD, Professor, Liver and Gastrointestinal Diseases Research Center, Tabriz Cystic Fibrosis Registry, Tabriz University of Medical Sciences, Tabriz, Iran.
2PhD, Assistant Professor, Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3MSc, Nutrition Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
4MD, Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran.
5Ph.D, Assistant Professor, Liver and Gastrointestinal Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
چکیده
Background: Cystic fibrosis (CF) is one of the most common genetic disorders in children. CF patients are susceptible to chronic lung infections and malabsorption. Although patient longevity is increased by multidisciplinary care, patients still suffer from respiratory failure and low quality of life. In this situation, CF patients tend to use complementary treatments. To the best of our knowledge there is no research about curcumin supplementation in CF patients; thus, we decided to investigate the effects of curcumin supplementation on anthropometric indices, and quality of life in children with cystic fibrosis.
Materials and Methods
This randomized control-controlled clinical study was conducted in Tabriz University of Medical Sciences, Iran. Forty CF patients were randomly sorted into intervention (n=20), and control (n=20) groups. Patients received 3 curcumin nanoparticles (80 mg; total dose 240 mg/d) for six consecutive months. Before and after intervention, height and weight were measured and quality of life of patients was evaluated by the Pediatric Quality of Life Inventory (PedsQL) 4.0 (CITE). 
Results: After intervention, the percentage of weight changes showed a significant increase in the curcumin group compared to the control group (7.48±4.68 vs. 4.15±4.68 kg, p=0.03). Following the intervention, only the percentage of change in emotional functioning scores was significant (p=0.01).  Subjects in the curcumin group showed a trend towards more improvement in terms of percentage change in physical functioning (19.28±31.65 vs.  15.24±47.14), and school functioning scores (40.96±42.93 vs 23.90±14.82) compared with the control group. 
Conclusion
Our findings suggest that curcumin may be a useful, inexpensive, and safe supplement in combination with conventional therapy to improve body weight in CF children.
کلیدواژه‌ها
Anthropometrics indices؛ Curcumin؛ Cystic fibrosis؛ Quality of life
مراجع
  1. Foundation CF. Patient Registry Report. Bethesda,
MD: Cystic Fibrosis Foundation. Accessed October 26, 2010.;http://www.cff.org/research/

clinicalresearch/patientregistryreport.

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