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Moulaei, Hadi, Namakin, Kokab, Namaei, Mohmmad Hasan, Azarkar, Zohreh. (1398). The Effect of Red Rose Extract on Helicobacter Pylori Eradication: A Randomized Controlled Clinical Trial. , 7(12), 10473-10480. doi: 10.22038/ijp.2019.40800.3439
Hadi Moulaei; Kokab Namakin; Mohmmad Hasan Namaei; Zohreh Azarkar. "The Effect of Red Rose Extract on Helicobacter Pylori Eradication: A Randomized Controlled Clinical Trial". , 7, 12, 1398, 10473-10480. doi: 10.22038/ijp.2019.40800.3439
Moulaei, Hadi, Namakin, Kokab, Namaei, Mohmmad Hasan, Azarkar, Zohreh. (1398). 'The Effect of Red Rose Extract on Helicobacter Pylori Eradication: A Randomized Controlled Clinical Trial', , 7(12), pp. 10473-10480. doi: 10.22038/ijp.2019.40800.3439
Moulaei, Hadi, Namakin, Kokab, Namaei, Mohmmad Hasan, Azarkar, Zohreh. The Effect of Red Rose Extract on Helicobacter Pylori Eradication: A Randomized Controlled Clinical Trial. , 1398; 7(12): 10473-10480. doi: 10.22038/ijp.2019.40800.3439

The Effect of Red Rose Extract on Helicobacter Pylori Eradication: A Randomized Controlled Clinical Trial

Journal of Pediatric Perspectives
مقاله 8، دوره 7، شماره 12 - شماره پیاپی 72، اسفند 2019، صفحه 10473-10480    اصل مقاله (356.1 K)
شناسه دیجیتال (DOI): 10.22038/ijp.2019.40800.3439
نویسندگان
Hadi Moulaei1؛ Kokab Namakin* 2؛ Mohmmad Hasan Namaei3؛ Zohreh Azarkar4
1Resident of Pediatric, Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
2Associate Professor of Pediatric, Birjand Cardiovascular Research Center, Birjand, Iran.
3Professor of Microbiology, Hepatic Research Center, Birjand University of Medical Sciences, Birjand, Iran.
4Associate Professor Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran.
چکیده
Background
Helicobacter pylori (H. pylori) is believed to be the most common bacterial infection worldwide. Herein, we aimed to investigate the effect of red rose extract on H. pylori eradication in 9 to 15 year-old children.
Materials and Methods
In this randomized controlled clinical trial,by the convenience sampling method 332 children were screened for H. pylori infection. Their stool samples were studied by the H. pylori Antigen Enzyme Immunoassay (EIA) Test Kit. Positive cases were divided into two groups and received either red rose extract or placebo for 14 days. The stool exam was repeated once again at treatment termination. Data were analyzed using SPSS software (version 21.0).
Results
In total 17.8% (n=59) of the 332 cases were positive for Helicobacter pylori stool antigen (HpSA), and 56 completed the study. The mean HpSA titer remained stable in the red rose extract treated group but it increased in the placebo group following intervention; however, the difference was statistically insignificant (p=0.57). Moreover, the intervention resulted in no difference in the eradication rate between the two groups (p=0.57).
Conclusion
Red rose extract did not reduce HpSA titer after intervention, so it cannot be solely considered as an alternative for H. pylori eradication. Further studies with a different dose and duration or with combined regimens are recommended.
کلیدواژه‌ها
Children؛ Helicobacter pylori؛ Red rose extract
آمار
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