سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Ranjbar, Akram, Gholami, Leila, Ghasemi, Hassan, Kheiripour, Nejat. (1398). EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity. , 7(1), 58-64. doi: 10.22038/nmj.2020.07.07
Akram Ranjbar; Leila Gholami; Hassan Ghasemi; Nejat Kheiripour. "EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity". , 7, 1, 1398, 58-64. doi: 10.22038/nmj.2020.07.07
Ranjbar, Akram, Gholami, Leila, Ghasemi, Hassan, Kheiripour, Nejat. (1398). 'EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity', , 7(1), pp. 58-64. doi: 10.22038/nmj.2020.07.07
Ranjbar, Akram, Gholami, Leila, Ghasemi, Hassan, Kheiripour, Nejat. EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity. , 1398; 7(1): 58-64. doi: 10.22038/nmj.2020.07.07

EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity

Nanomedicine Journal
مقاله 7، دوره 7، شماره 1، فروردین 2020، صفحه 58-64    اصل مقاله (346.77 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2020.07.07
نویسندگان
Akram Ranjbar1؛ Leila Gholami1؛ Hassan Ghasemi2؛ Nejat Kheiripour* 3
1Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran
3Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
چکیده
Objective(s): Aluminum phosphide (AlP) is commonly used pesticide which could cause poisoning mainly through the induction of oxidative stress. The present study aimed to evaluate the effects of nano-curcumin and curcumin on the oxidant and antioxidant system in the liver mitochondria using AIP-induced toxicity model.
Materials and Methods: In this study, 36 male albino Wistar rats were randomly divided into six groups (n=6). The control subjects and animals poisoned with AlP (2 mg/kg) received treatment with and without nano-curcumin (100 mg/kg) and curcumin (100 mg/kg) for seven days. Mitochondria were isolated from the liver and analyzed in terms of lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol groups (TTGs), superoxide dismutase (SOD), and catalase activity. In addition, mitochondrial viability was assessed.
Results: AlP caused a significant increase in the LPO levels, while significantly decreasing TAC, TTG, SOD, catalase activity, and mitochondrial viability compared to the controls (P<0.05). Moreover, nano-curcumin treatment significantly enhanced TAC, TTG, SOD, and mitochondrial viability (P<0.05). Curcumin could also improve TTG and mitochondrial viability (P<0.05).
Conclusion: According to the results, nano-curcumin exerted protective effects against AlP-induced experimental toxicity, and the effect was attributed to the antioxidant properties of this compound.
کلیدواژه‌ها
Aluminum Phosphide؛ Curcumin؛ Mitochondria؛ Nano-curcumin؛ Oxidative Stress
مراجع

1.Halvaei Z, Tehrani H, Soltaninejad K, Abdollahi M, Shadnia S. Vitamin E as a novel therapy in the treatment of acute aluminum phosphide poisoning. Turk J Med Sci. 2017; 47(3): 795-800.
2.Yan H, Xiang P, Zhang S, Shen B, Shen M. Diagnosis of aluminum phosphide poisoning using a new analytical approach: forensic application to a lethal intoxication. Int J Legal Med. 2017; 131(4): 1001-1007.
3.Tehrani H, Halvaie Z, Shadnia S, Soltaninejad K, Abdollahi M. Protective effects of N-acetylcysteine on aluminum phosphide-induced oxidative stress in acute human poisoning. Clin Toxicol. 2013; 51(1): 23-28.
4.Moazezi Z, Abedi SH. A successful management of aluminum phosphide intoxication. Caspian J Intern Med. 2011; 2(3): 286-288.
5.Baghaei A, Solgi R, Jafari A, Abdolghaffari AH, Golaghaei A, Asghari MH, Baeeri M, Ostad SN, Sharifzadeh M, Abdollahi M. Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-L-carnitine. Environ Toxicol Pharmacol. 2016; 42: 30-37.
6.Karimani A, Mohammadpour AH, Zirak MR, Rezaee R, Megarbane B, Tsatsakis A, Karimi G. Antidotes for aluminum phosphide poisoning - An update. Toxicol Rep. 2018; 5: 1053-1059.
7.Saikaew R, Marsal P, Grenier B, Dubas ST. Temperature controlled loading and release of curcumin in polyelectrolyte multilayers thin films. Mater Let. 2018; 215: 38-41.
8.Sharangi AB, Acharya S. Spices in India and Beyond: The Origin, History, Tradition and Culture. Indian Spices: Springer; 2018: 1-11.
9.Ghasemi H, Einollahi B, Kheiripour N, Hosseini-Zijoud S-R, Farhadian Nezhad M. Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes. Iran J Basic Med Sci. 2019; 22(4): 376-383.
10.Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, Zhou B, Rodrigues Hoffmann A, Basu R, Guo S, Majeti NVRK. Nano‐curcumin safely prevents streptozotocin‐induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus. British journal of pharmacology. 2017; 174(13): 2074-2084.
11.Bustamante J, Nutt L, Orrenius S, Gogvadze V. Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition. Toxicol Appl Pharmacol. 2005; 207(2 Suppl): 110-116.
12.Kruger NJ. The Bradford method for protein quantitation. The protein protocols handbook: Springer; 2002: 15-21.
13.Ghadermazi R, Khoshjou F, Hossini Zijoud SM, Behrooj H, Kheiripour N, Ganji M, Moridi H, Mohammadi M, Ranjbar A. Hepatoprotective effect of tempol on oxidative toxic stress in STZ-induced diabetic rats. Toxin rev. 2018; 37(1): 82-86.
14.Shateri H, Ranjbar A, Kheiripour N, Ghasemi H, Pourfarjam Y, Habibitabar E, Gholami H, Moridi H. Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats. Life Sci. 2019; 221: 65-71.
15.Mehri N, Felehgari H, Harchegani A, Behrooj H, Kheiripour N, Ghasemibasir H, Mirhoseini M , Ranjbar A. Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats. J Herbmed Pharmacol. 2016; 5 (3): 116-119.
16.Ilbeigi D, Nourbakhsh M, Khaghani S, Einollahi N, Kheiripour N, Gholinejad Z, Alaee M, Saberian M. Enterolactone Reduces Telomerase Activity and The Level of Its Catalytic Subunit in Breast Cancer Cells. Cell J. 2017; 19(Suppl 1): 37-43.
17.Kariman H, Heydari K, Fakhri M, Shahrami A, Dolatabadi AA, Mohammadi HA, Gharibi M. Aluminium phosphide poisoning and oxidative stress. J Med Toxicol. 2012; 8(3): 281-284.
18.Gouda AS, El-Nabarawy NA, Ibrahim SF. Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats. Toxicol Rep. 2018; 5: 209-212.
19.Wu Z, Du Y, Xue H, Wu Y, Zhou B. Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production. Neurobiol Aging. 2012;33(1):199. e1. e12.
20.Afolabi OK, Wusu AD, Ugbaja R, Fatoki JO. Aluminium phosphide-induced testicular toxicity through oxidative stress in Wistar rats: Ameliorative role of hesperidin. Toxicology Research and Application. 2018; 2: 1-11.
21.Anand R, Sharma D, Verma D, Bhalla A, Gill K, Singh S. Mitochondrial electron transport chain complexes, catalase and markers of oxidative stress in platelets of patients with severe aluminum phosphide poisoning. Hum Exp Toxicol. 2013; 32(8): 807-816.
22.Anand R, Kumari P, Kaushal A, Bal A, Wani WY, Sunkaria A, Dua R, Singh S, Bhalla A, Gill KD.. Effect of acute aluminum phosphide exposure on rats—A biochemical and histological correlation. Toxicol Lett. 2012; 215(1): 62-69.
23.Mehrpour O, Abdollahi M, Sharifi MD. Oxidative stress and hyperglycemia in aluminum phosphide poisoning. J Res Med Sci. 2014; 19(2): 196-196.
24.Hsu C-H, Han B-C, Liu M-Y, Yeh C-Y, Casida JE. Phosphine-induced oxidative damage in rats: attenuation by melatonin. Free Radic Biol Med. 2000; 28(4): 636-642.
25.Chugh SN, Arora V, Sharma A, Chugh K. Free radical scavengers & lipid peroxidation in acute aluminium phosphide poisoning. Indian J Med Res. 1996; 104: 190-193.
26.Zhang H, Tsao R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci. 2016; 8: 33-42.
27.Głombik K, Basta-Kaim A, Sikora-Polaczek M, Kubera M, Starowicz G, Styrna J. Curcumin influences semen quality parameters and reverses the di (2-ethylhexyl) phthalate (DEHP)-induced testicular damage in mice. Pharmacol Rep. 2014; 66(5): 782-787.
28.Lee W-H, Loo C-Y, Bebawy M, Luk F, Mason RS, Rohanizadeh R. Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol. 2013; 11(4): 338-378.
29.Rashid K, Chowdhury S, Ghosh S, Sil PC. Curcumin attenuates oxidative stress induced NFκB mediated inflammation and endoplasmic reticulum dependent apoptosis of splenocytes in diabetes. Biochem Pharmacol. 2017; 143: 140-155.
30.Samarghandian S, Azimi-Nezhad M, Farkhondeh T, Samini F. Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomed Pharmacother. 2017; 87: 223-229.
31.Zhao L, Gu Q, Xiang L, Dong X, Li H, Ni J, Wan L, Cai G, Chen G. Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats. Ther Clin Risk Manag. 2017; 13: 1099-1105.
32.Shetty D, Kim YJ, Shim H, Snyder JP. Eliminating the heart from the curcumin molecule: monocarbonyl curcumin mimics (MACs). Molecules. 2014; 20(1): 249-292.
33.Rahimi HR, Nedaeinia R, Shamloo AS, Nikdoust S, Oskuee RK. Novel delivery system for natural products: Nano-curcumin formulations. Avicenna J Phytomed. 2016; 6(4): 383-398.
34.Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Mobarhan MG, Kazemi Oskuee R. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial. Avicenna J Phytomed. 2016; 6(5): 567-577.
35.Yahfoufi N, Alsadi N, Jambi M, Matar C. The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients. 2018; 10(11): 1618-1641.
36.Jagetia GC, Rajanikant GK. Curcumin Stimulates the Antioxidant Mechanisms in Mouse Skin Exposed to Fractionated γ-Irradiation. Antioxidants (Basel). 2015; 4(1): 25-41.

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