سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Shariati, Marina, Azarbayjani, Mohammad Ali, Kaka, Gholam Reza, Zilaei Bouri, Shirin. (1398). The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2). , 8(1), 40-47. doi: 10.22038/jnfh.2019.41061.1202
Marina Shariati; Mohammad Ali Azarbayjani; Gholam Reza Kaka; Shirin Zilaei Bouri. "The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2)". , 8, 1, 1398, 40-47. doi: 10.22038/jnfh.2019.41061.1202
Shariati, Marina, Azarbayjani, Mohammad Ali, Kaka, Gholam Reza, Zilaei Bouri, Shirin. (1398). 'The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2)', , 8(1), pp. 40-47. doi: 10.22038/jnfh.2019.41061.1202
Shariati, Marina, Azarbayjani, Mohammad Ali, Kaka, Gholam Reza, Zilaei Bouri, Shirin. The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2). , 1398; 8(1): 40-47. doi: 10.22038/jnfh.2019.41061.1202

The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2)

Journal of Nutrition,Fasting and Health
مقاله 8، دوره 8، شماره 1، خرداد 2020، صفحه 40-47    اصل مقاله (369.75 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/jnfh.2019.41061.1202
نویسندگان
Marina Shariati* 1؛ Mohammad Ali Azarbayjani2؛ Gholam Reza Kaka3؛ Shirin Zilaei Bouri4
1PhD of Exercise physiology, Shoushtar Branch, Islamic Azad University (I.A.U), Shoushtar, Iran
2Professor of Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University (I.A.U), Tehran, Iran
3Associate Professor of Neurosciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
4Assistant Professor, Department of Physical Education & Sport Sciences , Masjed-Soleiman Branch, Islamic Azad University (I.A.U), Masjed-Soleiman, Iran
چکیده
Introduction:studies have shown that the increase of active oxygen species is associated with damage to bone cells and the role of exercise and vitamin D on bone health has been proven;the aim of this study was to investigate the interactive effects of aerobic exercise with vitamin D supplements on bone resorption markers in rats exposed to oxidative damage induced by H2O2.
Methods: Sixty male adult male Wistar rats were randomly divided into 10 groups of six rats including:1)1 mmol/kg H2O2, 2)2 mmol/kg H2O2, 3)1mmol/kg H2O2+vitamin D,4) 1mmol/kg H2O2+aerobic training,5)1mmol/kg H2O2+Vitamin D+aerobic training,6)2 mmol/kg H2O2+Vitamin D,7)2mmol/kg H2O2+aerobic training,8)2mmol/kg H2O2+Vitamin D+aerobic training;9)Sham (D-methyl- Sulfoxide+normal saline); and(10)control and for 8 weeks were under the protocol of intervention.The levels of TRACP/5B and NTX were measured by ELISA method. Two-way and one-way ANOVA with Tukey’s post hoc test was used to analysis of data (p≤0.05).
Results: 1and 2 mmol/kg H2O2 had no significant effect on NTX and TRACP/5B levels(p≥0/05). Eight weeks of aerobic training increased of NTX levels in rats exposed to 2mmol/kg H2O2 (p≤0/05).Eight weeks of Vitamine D had no significant effect on NTX and TRACP/5B levels (p≥0/05).Also eight weeks of aerobic training along with Vitamin D had no interactive effects on increase of NTX and TRACP/5B levels in rats exposed to 1and 2mmol/kg H2O2(p≥0/05).
Conclusion: It seems that doses of 1 and 2mg/kg H2O2 have not significant effect on changes in bone resorption markers,but aerobic exercise had a significant effect on NTX increase in rats exposed to oxidative damage induced by 2mg/kg H2O2.
کلیدواژه‌ها
Training؛ Vitamin D؛ Bone؛ H2O2
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