Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 11، دوره 9، شماره 6، بهمن و اسفند 2019، صفحه 597-605 اصل مقاله (762.24 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2019.13587 | ||
| نویسندگان | ||
| Maryam Hoseindoost1؛ Mohammad Reza Alipour2؛ Fereshteh Farajdokht1؛ Roghayeh Diba1؛ Parvin Bayandor1؛ Keivan Mehri3؛ Sepehr Nayebi Rad4؛ Shirin Babri* 3 | ||
| 1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. | ||
| 4Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. | ||
| چکیده | ||
| Objective: In the present study, we aimed to examine the effect of troxerutin treatment on levels of brain-derived neurotrophic factor (BDNF), and tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), as pro-inflammatory cytokines, in the blood and hippocampus of high-fat diet (HFD) fed dams and their male offspring. Materials and Methods: Forty virgin female Wistar rats, 3 weeks old, were divided into two groups (n=20/per group) and fed control diet (CD), or HFD for 8 weeks. After mating, pregnant animals were assigned to four subgroups including: control (CD), control+troxerutin (CD+T), high-fat diet (HFD), and HFD+troxerutin (HFD+T) groups. HFD was continued during pregnancy and lactation. Troxerutin (150 mg/kg/day, P.O.) was administered during pregnancy in the CD+T and HFD+T groups. On postnatal day (PND) 21, male offspring were separated and fed a normal diet until PND 90. Inflammatory cytokines (TNF-α, and IL-6) and BDNF levels were measured in the serum and hippocampal samples using rat-specific enzyme-linked immunosorbent assay (ELISA) kits. Results: Our findings showed a significant increase in the serum levels of TNF-α and IL-6, but a decrease in BDNF levels in the serum of HFD-fed dams in comparison with CD group, which was reversed by troxerutin. Moreover, troxerutin treatment, during pregnancy, significantly decreased TNF-α and IL-6 levels, but increased BDNF level in the serum and hippocampus of HFD+T offspring in comparison with HFD offspring. Conclusion: These results showed that troxerutin could prevent the harmful effects of maternal HFD on their offspring through inhibition of pro-inflammatory cytokines and elevation of BDNF levels. | ||
| کلیدواژهها | ||
| Troxerutin؛ Maternal high fat diet؛ BDNF؛ Inflammatory cytokines | ||
| مراجع | ||
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Ashino NG, Saito KN, Souza FD, Nakutz FS, Roman EA, Velloso LA, Torsoni AS, Torsoni MA. 2012. Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver. J Nutr Biochem, 23: 341-348.
Badalzadeh R, Baradaran B, Alihemmati A, Yousefi B, Abbaszadeh A. 2016. Troxerutin preconditioning and Ischemic postconditioning modulate inflammatory response after myocardial ischemia/reperfusion injury in rat model. Inflammation, 40: 136-143.
Bayandor P, Farajdokht F, Mohaddes G, Diba R, Hosseindoost M, Mehri K, Zavvari Oskuye Z, Babri S. 2018. The effect of troxerutin on anxiety-and depressive-like behaviours in the offspring of high-fat diet fed dams. Arch Physiol Biochem, 125: 156-162.
Benkalfat NB, Merzouk H, Bouanane S, Merzouk S-A, Bellenger J, Gresti J, Tessier C, Narce M. 2011. Altered adipose tissue metabolism in offspring of dietary obese rat dams. Clin Sci, 121: 19-28.
Bilbo SD, Tsang V. 2010. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J, 24: 2104-2115.
Boitard C, Cavaroc A, Sauvant J, Aubert A, Castanon N, Layé S, Ferreira G. 2014. Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats. Brain Behav Immun, 40: 9-17.
Boitard C, Etchamendy N, Sauvant J, Aubert A, Tronel S, Marighetto A, Layé S, Ferreira G. 2012. Juvenile, but not adult exposure to high‐fat diet impairs relational memory and hippocampal neurogenesis in mice. Hippocampus, 22: 2095-2100.
Challier J, Basu S, Bintein T, Minium J, Hotmire K, Catalano P, Hauguel-de Mouzon S. 2008. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta, 29: 274-281.
Chung HK, Choi SM, Ahn BO, Kwak HH, Kim JH, Kim WB. 2005. Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy. Arzneimittelforschung, 55: 573-580.
Datta S, Siwek DF, Huang MP. 2009. Improvement of two-way active avoidance memory requires protein kinase a activation and brain-derived neurotrophic factor expression in the dorsal hippocampus. J Mol Neurosci, 38: 257-264.
Diba R, Mohaddes G, Mirzaie Bavil F, Farajdokht F, Bayandor P, Hosseindoost M, Mehri K, Zavvari Oskuye Z, Babri S. 2018. Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring. Iran J Basic Med Sci, 21: 682-687.
Erickson KI, Prakash RS, Voss MW, Chaddock L, Heo S, McLaren M, Pence BD, Martin SA, Vieira VJ, Woods JA. 2010. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci, 30: 5368-5375.
Fan S-h, Zhang Z-f, Zheng Y-l, Lu J, Wu D-m, Shan Q, Hu B, Wang Y-y. 2009. Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation. Int Immunopharmacol, 9: 91-96.
Farajdokht F, Amani M, Bavil FM, Alihemmati A, Mohaddes G, Babri S. 2017. Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis. EXCLI, 16: 1081-1089.
Giriko CÁ, Andreoli CA, Mennitti LV, Hosoume LF, dos Santos Souto T, da Silva AV, Mendes-da-Silva C. 2013. Delayed physical and neurobehavioral development and increased aggressive and depression-like behaviors in the rat offspring of dams fed a high-fat diet. Int J Dev Neurosci, 31: 731-739.
Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R. 2008. BDNF is a novel marker of cognitive function in ageing women: the DR’s EXTRA Study. Neurobiol Learn Mem, 90: 596-603.
Lu J, Wu D-m, Zheng Z-h, Zheng Y-l, Hu B, Zhang Z-f. 2011. Troxerutin protects against high cholesterol-induced cognitive deficits in mice. Brain, 134: 783-797.
Macready AL, Kennedy OB, Ellis JA, Williams CM, Spencer JP, Butler LT. 2009. Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies. Genes Nutr, 4: 227-242.
Madan JC, Davis JM, Craig WY, Collins M, Allan W, Quinn R, Dammann O. 2009. Maternal obesity and markers of inflammation in pregnancy. Cytokine, 47: 61-64.
Molteni R, Barnard R, Ying Z, Roberts C, Gomez-Pinilla F. 2002. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience, 112: 803-814.
Niculescu MD, Lupu DS. 2009. High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci, 27: 627-633.
Noble EE, Mavanji V, Little MR, Billington CJ, Kotz CM, Wang C. 2014. Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons. Neurobiol Learn Mem, 114: 40-50.
Parente LB, Aguila MB, Mandarim-de-Lacerda CA. 2008. Deleterious effects of high-fat diet on perinatal and postweaning periods in adult rat offspring. Clin Nutr, 27: 623-634.
Pelleymounter MA, Cullen MJ, Wellman CL. 1995. Characteristics of BDNF-induced weight loss. Exp Neurol, 131: 229-238.
Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, Bruce-Keller AJ. 2010. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol, 219: 25-32.
Sasaki A, De Vega W, St-Cyr S, Pan P, McGowan P. 2013. Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood. Neuroscience, 240: 1-12.
Souza LC, Antunes MS, Borges Filho C, Del Fabbro L, de Gomes MG, Goes ATR, Donato F, Prigol M, Boeira SP, Jesse CR. 2015. Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain. Pharmacol Biochem Behav, 134: 22-30.
Taliaz D, Stall N, Dar D, Zangen A. 2010. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry, 15: 80-92.
Tozuka Y, Wada E, Wada K. 2009. Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring. FASEB J, 23: 1920-1934.
Wu A, Ying Z, Gomez‐Pinilla F. 2004. The interplay between oxidative stress and brain‐derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci, 19: 1699-1707.
Zhang Z, Wang X, Zheng G, Shan Q, Lu J, Fan S, Sun C, Wu D, Zhang C, Su W. 2016. Troxerutin attenuates enhancement of hepatic gluconeogenesis by inhibiting NOD activation-mediated inflammation in high-fat diet-treated mice. Int J Mol Sci, 18: 31.
Zhou D, Pan Y-X. 2015. Pathophysiological basis for compromised health beyond generations: role of maternal high-fat diet and low-grade chronic inflammation. J Nutr. Biochem, 26: 1-8. | ||
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