سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Alimohamadi, Raheleh, Fatemi, Iman, Naderi, Soudabeh, Hakimizadeh, Elham, Rahmani, Mohammad-Reza, Allahtavakoli, Mohammad. (1398). Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion. , 22(9), 1097-1101. doi: 10.22038/ijbms.2019.31692.7625
Raheleh Alimohamadi; Iman Fatemi; Soudabeh Naderi; Elham Hakimizadeh; Mohammad-Reza Rahmani; Mohammad Allahtavakoli. "Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion". , 22, 9, 1398, 1097-1101. doi: 10.22038/ijbms.2019.31692.7625
Alimohamadi, Raheleh, Fatemi, Iman, Naderi, Soudabeh, Hakimizadeh, Elham, Rahmani, Mohammad-Reza, Allahtavakoli, Mohammad. (1398). 'Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion', , 22(9), pp. 1097-1101. doi: 10.22038/ijbms.2019.31692.7625
Alimohamadi, Raheleh, Fatemi, Iman, Naderi, Soudabeh, Hakimizadeh, Elham, Rahmani, Mohammad-Reza, Allahtavakoli, Mohammad. Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion. , 1398; 22(9): 1097-1101. doi: 10.22038/ijbms.2019.31692.7625

Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion

Iranian Journal of Basic Medical Sciences
مقاله 17، دوره 22، شماره 9، آذر 2019، صفحه 1097-1101    اصل مقاله (802.69 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.31692.7625
نویسندگان
Raheleh Alimohamadi1؛ Iman Fatemi2؛ Soudabeh Naderi1؛ Elham Hakimizadeh3، 4؛ Mohammad-Reza Rahmani3، 4؛ Mohammad Allahtavakoli* 3، 4
1Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
3Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
چکیده
Objective(s): Previous studies have indicated that phytoestrogens induce estrogenic as well as anti-inflammatory effects, and they are found in high abundance in the extracts of some herbs such as Vitex Agnus Castus (VAC). Therefore, we investigated the effect of VAC extract on ovariectomized mice after the induction of permanent middle cerebral artery occlusion (PMCAO) model.
Materials and Methods: In this study, 50 mice ranging from 25 to 35 g were divided into five experimental groups as follows: Control, VAC, Estrogen, Tamoxifen, and Tamoxifen-VAC.  Animals were ovariectomized, and after 30 days of treatment, they were given PMCAO induction. Behavioral assessment (adhesive removal and wire hanging tests) was evaluated 24 hr, 48 hr, and one week after induction of stroke. The infarct volume, as well as serum levels of matrix metalloproteinase-9 (MMP-9) and interleukin-10 (IL-10), were measured one week after stroke.
Results: One week after stroke, in both VAC and estrogen groups, the infarct size reduced in comparison with the control group. Estrogen and VAC extract improved adhesive removal and wire hanging test, increased the level of IL-10, and decreased the level of MMP-9 compared with the control group. In addition, co-administration of tamoxifen and VCA extract had no significant effect on measured indices compared with control and tamoxifen groups.
Conclusion: Based on our findings, VAC extract has neuroprotective properties and can reduce stroke injuries in PMCAO-induced ovariectomized mice via anti-inflammatory and estrogenic properties.
کلیدواژه‌ها
Anti-inflammatory؛ Mice؛ Ovariectomy؛ Stroke؛ Vitex agnus-castus
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