Bahaloo, Maryam, Rezvani, Mohammad Ebrahim, Farashahi Yazd, Ehsan, Davari, Mohammad Hossein, Mehrparvar, Amir Houshang. (1398). Effect of Myricetin on the Prevention of Noise-Induced Hearing Loss-An Animal Model. , 31(5), 273-279. doi: 10.22038/ijorl.2019.32384.2099
Maryam Bahaloo; Mohammad Ebrahim Rezvani; Ehsan Farashahi Yazd; Mohammad Hossein Davari; Amir Houshang Mehrparvar. "Effect of Myricetin on the Prevention of Noise-Induced Hearing Loss-An Animal Model". , 31, 5, 1398, 273-279. doi: 10.22038/ijorl.2019.32384.2099
Bahaloo, Maryam, Rezvani, Mohammad Ebrahim, Farashahi Yazd, Ehsan, Davari, Mohammad Hossein, Mehrparvar, Amir Houshang. (1398). 'Effect of Myricetin on the Prevention of Noise-Induced Hearing Loss-An Animal Model', , 31(5), pp. 273-279. doi: 10.22038/ijorl.2019.32384.2099
Bahaloo, Maryam, Rezvani, Mohammad Ebrahim, Farashahi Yazd, Ehsan, Davari, Mohammad Hossein, Mehrparvar, Amir Houshang. Effect of Myricetin on the Prevention of Noise-Induced Hearing Loss-An Animal Model. , 1398; 31(5): 273-279. doi: 10.22038/ijorl.2019.32384.2099

Effect of Myricetin on the Prevention of Noise-Induced Hearing Loss-An Animal Model

Iranian Journal of Otorhinolaryngology
مقاله 3، دوره 31، شماره 5 - شماره پیاپی 106، آذر و دی 2019، صفحه 273-279    اصل مقاله (350.84 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2019.32384.2099
نویسندگان
Maryam Bahaloo1؛ Mohammad Ebrahim Rezvani2؛ Ehsan Farashahi Yazd3؛ Mohammad Hossein Davari4؛ Amir Houshang Mehrparvar* 1
1Industrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2Department of Physiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
چکیده
Introduction:
Exposure to hazardous noise induces one of the forms of acquired and preventable hearing loss that is noise-induced hearing loss (NIHL). Considering oxidative stress as the main mechanism of NIHL, it is possible that myricetin can protect NIHL by its antioxidant effect. Therefore, the present study aimed to investigate the preventive effect of myricetin on NIHL.
 
Materials and Methods:
A total of 21 Wistar rats were randomly divided into five groups, namely (1) noise exposure only as control group, (2) noise exposure with the vehicle of myricetin as solvent group, (3) noise exposure with myricetin 5 mg/kg as myricetin 5 mg group, (4) noise exposure with myricetin 10 mg/kg as myricetin 10 mg group, (5) and non-exposed as sham group. The hearing status of each animal was assessed by Distortion Product Otoacoustic Emissions.
 
Results:
The levels of response amplitude decreased after the exposure to noise in all groups and returned to a higher level after 14 days of noise abstinence at most frequencies; however, the difference was not significant in the myricetin-receiving or control groups.
 
Conclusion:
The results of this study showed that two doses of myricetin (5 and 10 mg/kg) administered intraperitoneally could not significantly decrease transient or permanent threshold shifts in rats exposed to loud noise. 
کلیدواژه‌ها
Antioxidant؛ Myricetin؛ Noise-Induced hearing loss؛ Prevention
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