Evaluation of Antibiotic Resistance Trend among Cystic Fibrosis Patients: A Single Center Study from 2014-2019 | ||
| Journal of Pediatric Perspectives | ||
| مقاله 7، دوره 8، شماره 1 - شماره پیاپی 73، فروردین 2020، صفحه 10719-10729 اصل مقاله (552.29 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijp.2019.41725.3517 | ||
| نویسندگان | ||
| Maryam Hassanzad1؛ Elham Sadati* 1؛ Fariba Ghorbani2؛ Hosseinali Ghaffaripour1؛ Poopak Farnia3؛ Mihan Porabdollah4؛ Noushin Baghaei1؛ Habib Emami5؛ Ali Akbar Velayati3 | ||
| 1Pediatric respiratory disease research center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. | ||
| 2Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran. | ||
| 3Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. | ||
| 4Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. | ||
| 5National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. | ||
| چکیده | ||
| Background: Antibiotic resistance in Cystic Fibrosis (CF) patients has been a serious issue in their survival. The objective of this study was to investigate the antibiogram trend in serial admissions among CF patients. Materials and Methods: In this retrospective descriptive-analytical study, from 2014 to 2019, 95 known cases of CF patients with repeated admissions at Masih Daneshvari Hospital, Tehran, Iran, were evaluated. Demographic data and para-clinical parameters were evaluated. Fourteen antibiotic disks were used to determine antibiotic resistance. Resistance trend in 2014 and 2018 was compared. Results: Out of 95 patients, 48 patients (52.2%) were female. The mean age of patients was 19.43 ± 6.7 years. Pseudomonas positive culture in the first admission was 68.4%; while it was 45.3% in the second admission and 28.4% in the third admission (p> 0.05). Staph positive culture was 20%; 18.9%, and 16.8%, respectively (p> 0.05). Pseudomonas aeruginosa was the most sensitive to vancomycin (93.8%), followed by colistin (93.3%) and ceftazidime (65.2%). There was no correlation between patients' age and multidrug resistance (MDR). FEV1 was significantly lower in both the patient with positive pseudomonas (p-value: 0.01), and culture and MDR (p= 0.023). Furthermore, in terms of antibiotic resistance over time, resistance to colistin statistically decreased from 25% in 2014 to 2% in 2018 (p= 0.02). Conclusion: Vancomycin, Colistin, Ceftazidim, Imipenem, Amikacin, and Gentamycin had the highest drug sensitivity; while Cefotaxime, Clindamycin, and Chloramphenicol antibiotics had a low sensitivity. From 2014 to 2019, resistance to Colistin dramatically decreased. | ||
| کلیدواژهها | ||
| Antibiotic Resistance؛ Cystic fibrosis؛ Drug resistance؛ Microbial culture | ||
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