Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 8، دوره 10، شماره 1، فروردین و اردیبهشت 2020، صفحه 70-77 اصل مقاله (415.99 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2019.13391 | ||
| نویسندگان | ||
| Fatemeh Forouzanfar1، 2؛ Hamed Ghazavi3؛ Mohammad Mahdi Vahedi4، 5؛ Kimia Tarah6؛ Zahra Yavari7؛ Azar Hosseini6؛ Azita Aghaee6؛ Hasan Rakhshandeh* 6 | ||
| 1Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 2Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 3Department for Population and Family Health, Vice Chancellery for Health, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 4Health Promotion Research Center, Zahedan University of Medical Science, Zahedan, Iran. | ||
| 5Department of Pharmacology, School of Medicine, Zahedan University of Medical Science, Zahedan, Iran. | ||
| 6Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 7Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| چکیده | ||
| Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice. Material and Methods: The hydro-alcoholic extract (HAE) of T. parthenium and three fractions of it, namely water fraction (WF), ethyl acetate fraction (EAF), and n-hexane fraction (NHF), were intraperitoneally (ip) administrated to mice 30 min before injection of sodium pentobarbital (30 mg/kg, ip). Then, 30 min after administration of HAE, motor coordination (rota-rod test) was evaluated. Besides, LD50 of HAE was determined and the cytotoxicity of HAE was evaluated in PC12 cells using the MTT assay. Results: HAE 50-200 mg/kg increased the sleeping time. EAF was the only fraction which could prolong the sleep duration and decrease sleep latency. The LD50 value was 4.8 g/kg. The extract induced no cytotoxic effects in PC12 cell line. Conclusion: The results suggested that T. parthenium potentiates pentobarbital hypnosis without causing toxic effects. Probably, its effects are mediated by the components present in EAF of this plant. | ||
| کلیدواژهها | ||
| Pentobarbital؛ PC12؛ Sleep؛ Tanacetum parthenium؛ Herbal medicine | ||
| مراجع | ||
|
Akhila JS, Shyamjith D, Alwar M. 2007. Acute toxicity studies and determination of median lethal dose. Current science, 917-920.
Akpulat HA, Tepe B, Sokmen A, Daferera D, Polissiou M. 2005. Composition of the essential oils of Tanacetum argyrophyllum (C. Koch) Tvzel. var. argyrophyllum and Tanacetum parthenium (L.) Schultz Bip. (Asteraceae) from Turkey." Biochem Syst Ecol, 33: 511-516.
Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. 2017. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev, 34: 10-22.
Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. 2009. Bioassay‐guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res, 23: 1075-1081.
Coleta M, Campos MG, Cotrim MD, de Lima TCM, da Cunha AP. 2008. Assessment of luteolin (3′, 4′, 5, 7-tetrahydroxyflavone) neuropharmacological activity. Behav Brain Res, 189: 75-82.
Datta S. 2010. Cellular and chemical neuroscience of mammalian sleep. Sleep Med, 11: 431-440.
Edewor-Kuponiyi TI. 2013. Plant-derived compounds with potential sedative and anxiolytic activities. Int Basic Appl Sci, 2: 63-78.
Emamghoreishi M, Heidari-Hamedani G. 2015. Sedative-hypnotic activity of extracts and essential oil of coriander seeds. Iran J Med Sci, 31: 22-27.
Ferreri MC, Gutiérrez ML, Gravielle M C. 2015. Tolerance to the sedative and anxiolytic effects of diazepam is associated with different alterations of GABAA receptors in rat cerebral cortex. Neurosci, 310: 152-162.
Hosseini A, Sobhanifar MA, Forouzanfar F, Aghaee A, Rakhshandeh H. 2018. Hypnotic effect of red cabbage (Brassica oleracea) on pentobarbital-induced sleep in mice. J Pharm Bioallied Sci, 10: 48-53.
Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, Ito M,.- Miyamoto K, Tsuji A, Kawai Y. 2011. Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med, 51: 1329-1336.
Jain NK, Kulkarni SK. 1999. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. J Ethnopharmacol, 68: 251-259.
Kambe D, Kotani M, Yoshimoto M, Kaku S, Chaki S, Honda K. 2010. Effects of quercetin on the sleep–wake cycle in rats: Involvement of gamma-aminobutyric acid receptor type A in regulation of rapid eye movement sleep. Brain Res, 1330: 83-88.
Khorasani A. 1371. Tehran, Iran: Islamic Culture Press Center; Makhzan-al' advieh: 159-160.
Long C, Sauleau P, David B, Lavaud C, Cassabois V, Ausseil F, Massiot G. 2003. Bioactive flavonoids of Tanacetum parthenium revisited. Phytochem, 64: 567-569.
Murillo-Rodríguez E, Arias-Carrión O, Sanguino-Rodríguez K, González-Arias M, Haro R. 2009. Mechanisms of sleep-wake cycle modulation. CNS Neurol Disord Drug Targets, 8: 245-253.
Pareek A, Suthar M, Rathore GS, Bansal V. 2011. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacogn Rev, 5: 103.
Paulke A, Schubert-Zsilavecz M, Wurglics M. 2006. Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection. J Chromatogr B, 832: 109-113.
Rakhshandah H, Shakeri MT, Ghasemzadeh MR. 2010. Comparative hypnotic effect of Rosa damascena fractions and Diazepam in Mice. Iran J Pharm Res, 6:193-197.
Riemann D, Nissen C, Palagini L, Otte A, Perlis ML, Spiegelhalder K. 2015. The neurobiology, investigation, and treatment of chronic insomnia. Lancet Neurol, 14: 547-558.
Tian S, Shi Y, Zhou X, Ge L, Upur H. 2011. Total polyphenolic (flavonoids) content and antioxidant capacity of different Ziziphora clinopodioides Lam. extracts. Pharmacogn Mag, 7: 65-68.
Vinkers CH, Olivier B. 2012. Mechanisms underlying tolerance after long-term benzodiazepine use: a future for subtype-selective GABAA receptor modulators? Adv Pharmacol Sci, 2012. 416864.
Williams CA, Harborne JB, Geiger H, Hoult JRS. 1999. The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties. Phytochem, 51: 417-423.
Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ. 2004. Flavonoid permeability across an in situ model of the blood–brain barrier. Free Radic Biol Med, 36: 592-604. | ||
|
آمار تعداد مشاهده مقاله: 21,124 تعداد دریافت فایل اصل مقاله: 1,814 |
||